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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8Y6B

Structure of human LGI1-ADAM22 complex in space group P212121

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
B	0004222	molecular_function	metalloendopeptidase activity
B	0006508	biological_process	proteolysis
B	0008237	molecular_function	metallopeptidase activity
C	0004222	molecular_function	metalloendopeptidase activity
C	0006508	biological_process	proteolysis
C	0008237	molecular_function	metallopeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CA A 804

Chain	Residue
A	GLU242
A	ASP325
A	CYS433
A	ASN436

site_id	AC2
Number of Residues	6
Details	binding site for residue CA A 805

Chain	Residue
A	ILE527
A	ARG504
A	ASP511
A	ILE512
A	GLU514
A	ASN526

site_id	AC3
Number of Residues	6
Details	binding site for residue CA A 806

Chain	Residue
A	GLU446
A	ASN449
A	PHE451
A	GLU456
A	ASP459
A	HOH901

site_id	AC4
Number of Residues	5
Details	binding site for residue CA D 604

Chain	Residue
D	ASP334
D	GLU336
D	ASP381
D	VAL382
D	GLU383

site_id	AC5
Number of Residues	6
Details	binding site for residue CA B 804

Chain	Residue
B	GLU446
B	ASN449
B	PHE451
B	GLU453
B	GLU456
B	ASP459

site_id	AC6
Number of Residues	6
Details	binding site for residue CA B 805

Chain	Residue
B	GLU242
B	ASP325
B	CYS433
B	ASN436
B	HOH903
B	HOH931

site_id	AC7
Number of Residues	5
Details	binding site for residue CA B 806

Chain	Residue
B	ASP511
B	ILE512
B	GLU514
B	ASN526
B	ILE527

site_id	AC8
Number of Residues	6
Details	binding site for residue CA C 804

Chain	Residue
C	GLU242
C	ASP325
C	CYS433
C	ASN436
C	HOH901
C	HOH916

site_id	AC9
Number of Residues	5
Details	binding site for residue CA C 805

Chain	Residue
C	ASP511
C	ILE512
C	GLU514
C	ASN526
C	ILE527

site_id	AD1
Number of Residues	6
Details	binding site for residue CA C 806

Chain	Residue
C	GLU446
C	ASN449
C	PHE451
C	GLU456
C	ASP459
C	HOH906

site_id	AD2
Number of Residues	6
Details	binding site for residue CA F 604

Chain	Residue
F	ASP334
F	GLU336
F	ASP381
F	VAL382
F	GLU383
F	LYS436

site_id	AD3
Number of Residues	6
Details	binding site for residue CA E 604

Chain	Residue
E	ASP334
E	GLU336
E	ASP381
E	VAL382
E	GLU383
E	LYS436

site_id	AD4
Number of Residues	1
Details	binding site for Mono-Saccharide NAG A 801 bound to ASN A 519

Chain	Residue
A	ASN519

site_id	AD5
Number of Residues	1
Details	binding site for Mono-Saccharide NAG A 802 bound to ASN A 634

Chain	Residue
A	ASN634

site_id	AD6
Number of Residues	2
Details	binding site for Mono-Saccharide NAG A 803 bound to ASN A 675

Chain	Residue
A	SER673
A	ASN675

site_id	AD7
Number of Residues	3
Details	binding site for Mono-Saccharide NAG B 801 bound to ASN B 519

Chain	Residue
B	MET499
B	SER517
B	ASN519

site_id	AD8
Number of Residues	3
Details	binding site for Mono-Saccharide NAG B 802 bound to ASN B 634

Chain	Residue
B	ASN607
B	ILE608
B	ASN634

site_id	AD9
Number of Residues	6
Details	binding site for Mono-Saccharide NAG B 803 bound to ASN B 675

Chain	Residue
B	ARG513
B	ASN675
B	VAL701
B	CYS702
B	ARG704
B	HOH907

site_id	AE1
Number of Residues	5
Details	binding site for Mono-Saccharide NAG C 801 bound to ASN C 519

Chain	Residue
A	GLY685
A	ILE687
C	MET499
C	SER517
C	ASN519

site_id	AE2
Number of Residues	2
Details	binding site for Mono-Saccharide NAG C 802 bound to ASN C 634

Chain	Residue
C	SER623
C	ASN634

site_id	AE3
Number of Residues	2
Details	binding site for Mono-Saccharide NAG C 803 bound to ASN C 675

Chain	Residue
C	SER673
C	ASN675

site_id	AE4
Number of Residues	2
Details	binding site for Mono-Saccharide NAG D 602 bound to ASN D 192

Chain	Residue
D	HIS190
D	ASN192

site_id	AE5
Number of Residues	3
Details	binding site for Mono-Saccharide NAG D 603 bound to ASN D 277

Chain	Residue
D	LYS259
D	ASN274
D	ASN277

site_id	AE6
Number of Residues	3
Details	binding site for Mono-Saccharide NAG D 601 bound to ASN D 422

Chain	Residue
D	ASN422
D	ARG389
D	THR421

site_id	AE7
Number of Residues	3
Details	binding site for Mono-Saccharide NAG E 601 bound to ASN E 192

Chain	Residue
B	VAL259
B	VAL260
E	ASN192

site_id	AE8
Number of Residues	5
Details	binding site for Mono-Saccharide NAG E 602 bound to ASN E 277

Chain	Residue
E	LYS259
E	ILE261
E	ASN274
E	ASN277
E	GLU325

site_id	AE9
Number of Residues	5
Details	binding site for Mono-Saccharide NAG E 603 bound to ASN E 422

Chain	Residue
E	ARG389
E	GLN412
E	ASN422
E	THR424
E	SER463

site_id	AF1
Number of Residues	2
Details	binding site for Mono-Saccharide NAG F 601 bound to ASN F 192

Chain	Residue
F	HIS190
F	ASN192

site_id	AF2
Number of Residues	3
Details	binding site for Mono-Saccharide NAG F 602 bound to ASN F 277

Chain	Residue
F	THR257
F	ASN274
F	ASN277

site_id	AF3
Number of Residues	3
Details	binding site for Mono-Saccharide NAG F 603 bound to ASN F 422

Chain	Residue
F	ARG389
F	ASN422
F	SER463

Functional Information from PROSITE/UniProt

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CvCnrHwiGSdC

Chain	Residue	Details
A	CYS700-CYS711

site_id	PS00427
Number of Residues	20
Details	DISINTEGRIN_1 Disintegrins signature. CsdGlCCk.KCkFqpmgtvCR

Chain	Residue	Details
A	CYS485-ARG504

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
D	ASN192
D	ASN277
D	ASN422
F	ASN192
F	ASN277
F	ASN422
E	ASN192
E	ASN277
E	ASN422

227111

PDB entries from 2024-11-06

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