8X63
CryoEM structure of the histamine H1 receptor-BRIL/Anti BRIL Fab complex with mepyramine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0004930 | molecular_function | G protein-coupled receptor activity |
| B | 0004969 | molecular_function | histamine receptor activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0016020 | cellular_component | membrane |
| B | 0020037 | molecular_function | heme binding |
| B | 0022900 | biological_process | electron transport chain |
| B | 0042597 | cellular_component | periplasmic space |
| B | 0043114 | biological_process | regulation of vascular permeability |
| B | 0045907 | biological_process | positive regulation of vasoconstriction |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIfSVFILCIDRYRsV |
| Chain | Residue | Details |
| B | ALA113-VAL129 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000305|PubMed:33828102, ECO:0007744|PDB:7DFL |
| Chain | Residue | Details |
| B | LEU30-TYR50 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 33 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:21697825 |
| Chain | Residue | Details |
| B | ALA51-LEU64 | |
| B | ASP124-ALA144 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000305|PubMed:33828102, ECO:0007744|PDB:7DFL |
| Chain | Residue | Details |
| B | TYR65-LEU89 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 35 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:21697825 |
| Chain | Residue | Details |
| B | MET90-ARG97 | |
| B | TRP165-THR188 | |
| B | CYS441-ASN446 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000305|PubMed:33828102, ECO:0007744|PDB:7DFL |
| Chain | Residue | Details |
| B | PRO98-ILE123 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000305|PubMed:33828102, ECO:0007744|PDB:7DFL |
| Chain | Residue | Details |
| B | SER145-GLY164 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000305|PubMed:33828102, ECO:0007744|PDB:7DFL |
| Chain | Residue | Details |
| B | TRP189-ALA211 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000305|PubMed:33828102, ECO:0007744|PDB:7DFL |
| Chain | Residue | Details |
| B | LEU417-PHE440 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000305|PubMed:33828102, ECO:0007744|PDB:7DFL |
| Chain | Residue | Details |
| B | GLU447-PRO469 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:33828102 |
| Chain | Residue | Details |
| B | ASP107 | |
| B | ASN198 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33828102, ECO:0007744|PDB:7DFL |
| Chain | Residue | Details |
| B | THR112 | |
| B | TYR431 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:15328002 |
| Chain | Residue | Details |
| B | THR140 | |
| B | THR142 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | BINDING: axial binding residue |
| Chain | Residue | Details |
| B | TRP312 | |
| B | ILE400 |
