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8WQE

Cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CUX1 (conformation 1)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000082biological_processG1/S transition of mitotic cell cycle
A0004842molecular_functionubiquitin-protein transferase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005829cellular_componentcytosol
A0016567biological_processprotein ubiquitination
A0019005cellular_componentSCF ubiquitin ligase complex
A0030163biological_processprotein catabolic process
A0030674molecular_functionprotein-macromolecule adaptor activity
A0030891cellular_componentVCB complex
A0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
A0031461cellular_componentcullin-RING ubiquitin ligase complex
A0031462cellular_componentCul2-RING ubiquitin ligase complex
A0031625molecular_functionubiquitin protein ligase binding
A0044877molecular_functionprotein-containing complex binding
A0097193biological_processintrinsic apoptotic signaling pathway
A0140627biological_processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
A0160072molecular_functionubiquitin ligase complex scaffold activity
B0002070biological_processepithelial cell maturation
B0005123molecular_functiondeath receptor binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006915biological_processapoptotic process
B0016567biological_processprotein ubiquitination
B0031462cellular_componentCul2-RING ubiquitin ligase complex
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0046872molecular_functionmetal ion binding
B0051438biological_processregulation of ubiquitin-protein transferase activity
B0060442biological_processbranching involved in prostate gland morphogenesis
B0060743biological_processepithelial cell maturation involved in prostate gland development
B0140627biological_processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
B1902041biological_processregulation of extrinsic apoptotic signaling pathway via death domain receptors
B1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
B2000001biological_processregulation of DNA damage checkpoint
C0000082biological_processG1/S transition of mitotic cell cycle
C0004842molecular_functionubiquitin-protein transferase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005730cellular_componentnucleolus
C0005829cellular_componentcytosol
C0016567biological_processprotein ubiquitination
C0019005cellular_componentSCF ubiquitin ligase complex
C0030163biological_processprotein catabolic process
C0030674molecular_functionprotein-macromolecule adaptor activity
C0030891cellular_componentVCB complex
C0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
C0031461cellular_componentcullin-RING ubiquitin ligase complex
C0031462cellular_componentCul2-RING ubiquitin ligase complex
C0031625molecular_functionubiquitin protein ligase binding
C0044877molecular_functionprotein-containing complex binding
C0097193biological_processintrinsic apoptotic signaling pathway
C0140627biological_processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
C0160072molecular_functionubiquitin ligase complex scaffold activity
D0002070biological_processepithelial cell maturation
D0005123molecular_functiondeath receptor binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006915biological_processapoptotic process
D0016567biological_processprotein ubiquitination
D0031462cellular_componentCul2-RING ubiquitin ligase complex
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0046872molecular_functionmetal ion binding
D0051438biological_processregulation of ubiquitin-protein transferase activity
D0060442biological_processbranching involved in prostate gland morphogenesis
D0060743biological_processepithelial cell maturation involved in prostate gland development
D0140627biological_processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
D1902041biological_processregulation of extrinsic apoptotic signaling pathway via death domain receptors
D1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
D2000001biological_processregulation of DNA damage checkpoint
F0001222molecular_functiontranscription corepressor binding
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005829cellular_componentcytosol
F0006367biological_processtranscription initiation at RNA polymerase II promoter
F0006368biological_processtranscription elongation by RNA polymerase II
F0016567biological_processprotein ubiquitination
F0030891cellular_componentVCB complex
F0031462cellular_componentCul2-RING ubiquitin ligase complex
F0031466cellular_componentCul5-RING ubiquitin ligase complex
F0031625molecular_functionubiquitin protein ligase binding
F0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
F0065003biological_processprotein-containing complex assembly
F0070449cellular_componentelongin complex
F0140958biological_processtarget-directed miRNA degradation
H0001222molecular_functiontranscription corepressor binding
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005829cellular_componentcytosol
H0006367biological_processtranscription initiation at RNA polymerase II promoter
H0006368biological_processtranscription elongation by RNA polymerase II
H0016567biological_processprotein ubiquitination
H0030891cellular_componentVCB complex
H0031462cellular_componentCul2-RING ubiquitin ligase complex
H0031466cellular_componentCul5-RING ubiquitin ligase complex
H0031625molecular_functionubiquitin protein ligase binding
H0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
H0065003biological_processprotein-containing complex assembly
H0070449cellular_componentelongin complex
H0140958biological_processtarget-directed miRNA degradation
Functional Information from PROSITE/UniProt
site_idPS01256
Number of Residues28
DetailsCULLIN_1 Cullin family signature. IKkcIevLIDKqYIeRsqasadeYsYvA
ChainResidueDetails
CILE718-ALA745

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues90
DetailsZN_FING: RING-type => ECO:0000255|PROSITE-ProRule:PRU00175
ChainResidueDetails
JCYS53-ASN98
ICYS53-ASN98
DHIS218
BHIS185
BCYS186
BHIS218

site_idSWS_FT_FI2
Number of Residues22
DetailsBINDING: BINDING => ECO:0000269|PubMed:11961546, ECO:0007744|PDB:1LDJ, ECO:0007744|PDB:1LDK, ECO:0007744|PDB:1U6G, ECO:0007744|PDB:2HYE, ECO:0007744|PDB:3DPL, ECO:0007744|PDB:3DQV, ECO:0007744|PDB:3RTR, ECO:0007744|PDB:4F52, ECO:0007744|PDB:4P5O
ChainResidueDetails
JCYS42
JCYS45
JCYS53
JCYS56
JCYS68
JCYS75
JHIS77
JHIS80
JHIS82
JCYS94
JASP97
ICYS42
ICYS45
ICYS53
ICYS56
ICYS68
ICYS75
IHIS77
IHIS80
IHIS82
ICYS94
IASP97

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:11961546, ECO:0007744|PDB:1LDJ, ECO:0007744|PDB:1LDK, ECO:0007744|PDB:1U6G, ECO:0007744|PDB:2HYE, ECO:0007744|PDB:3DQV, ECO:0007744|PDB:3RTR, ECO:0007744|PDB:4F52, ECO:0007744|PDB:4P5O
ChainResidueDetails
JCYS83
HSER108
ICYS83
HSER111

219869

PDB entries from 2024-05-15

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