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8WJX

ADP-bound purinergic receptor 1 in complex with miniGs/q

Functional Information from GO Data
ChainGOidnamespacecontents
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0045202cellular_componentsynapse
G0048144biological_processfibroblast proliferation
G0070062cellular_componentextracellular exosome
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
R0001621molecular_functionG protein-coupled ADP receptor activity
R0001934biological_processpositive regulation of protein phosphorylation
R0001973biological_processG protein-coupled adenosine receptor signaling pathway
R0004930molecular_functionG protein-coupled receptor activity
R0005515molecular_functionprotein binding
R0005524molecular_functionATP binding
R0005886cellular_componentplasma membrane
R0005929cellular_componentcilium
R0006811biological_processmonoatomic ion transport
R0007166biological_processcell surface receptor signaling pathway
R0007186biological_processG protein-coupled receptor signaling pathway
R0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
R0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
R0007204biological_processpositive regulation of cytosolic calcium ion concentration
R0007596biological_processblood coagulation
R0008347biological_processglial cell migration
R0008360biological_processregulation of cell shape
R0009612biological_processresponse to mechanical stimulus
R0009986cellular_componentcell surface
R0010700biological_processnegative regulation of norepinephrine secretion
R0014069cellular_componentpostsynaptic density
R0016323cellular_componentbasolateral plasma membrane
R0016324cellular_componentapical plasma membrane
R0023019biological_processsignal transduction involved in regulation of gene expression
R0030425cellular_componentdendrite
R0031686molecular_functionA1 adenosine receptor binding
R0032962biological_processpositive regulation of inositol trisphosphate biosynthetic process
R0035589biological_processG protein-coupled purinergic nucleotide receptor signaling pathway
R0038023molecular_functionsignaling receptor activity
R0042597cellular_componentperiplasmic space
R0042755biological_processeating behavior
R0043270biological_processpositive regulation of monoatomic ion transport
R0043531molecular_functionADP binding
R0044297cellular_componentcell body
R0045028molecular_functionG protein-coupled purinergic nucleotide receptor activity
R0045031molecular_functionG protein-coupled ATP receptor activity
R0045211cellular_componentpostsynaptic membrane
R0045944biological_processpositive regulation of transcription by RNA polymerase II
R0046872molecular_functionmetal ion binding
R0046887biological_processpositive regulation of hormone secretion
R0046982molecular_functionprotein heterodimerization activity
R0048787cellular_componentpresynaptic active zone membrane
R0051649biological_processestablishment of localization in cell
R0060406biological_processpositive regulation of penile erection
R0070374biological_processpositive regulation of ERK1 and ERK2 cascade
R0070848biological_processresponse to growth factor
R0071318biological_processcellular response to ATP
R0071407biological_processcellular response to organic cyclic compound
R0071415biological_processcellular response to purine-containing compound
R0072659biological_processprotein localization to plasma membrane
R0097110molecular_functionscaffold protein binding
R0097746biological_processblood vessel diameter maintenance
R0098978cellular_componentglutamatergic synapse
R0099509biological_processregulation of presynaptic cytosolic calcium ion concentration
R2000300biological_processregulation of synaptic vesicle exocytosis
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. GSIlFLTCISAHRYSgV
ChainResidueDetails
RGLY137-VAL153

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299
BVAL327-GLY341

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: axial binding residue
ChainResidueDetails
RTRP-108
RILE-13

site_idSWS_FT_FI2
Number of Residues22
DetailsTRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:25822790
ChainResidueDetails
RTYR52-TRP74

site_idSWS_FT_FI3
Number of Residues52
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:25822790
ChainResidueDetails
RMET75-SER87
RHIS148-LYS166
RGLY238-TYR260

site_idSWS_FT_FI4
Number of Residues21
DetailsTRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:25822790
ChainResidueDetails
RVAL88-PHE109

site_idSWS_FT_FI5
Number of Residues58
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:25822790
ChainResidueDetails
RTYR110-LYS125
RTYR189-TYR214
RARG285-TYR303

site_idSWS_FT_FI6
Number of Residues21
DetailsTRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:25822790
ChainResidueDetails
RLEU126-ALA147

site_idSWS_FT_FI7
Number of Residues21
DetailsTRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:25822790
ChainResidueDetails
RASN167-PHE188

site_idSWS_FT_FI8
Number of Residues22
DetailsTRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:25822790
ChainResidueDetails
RPHE215-TYR237

site_idSWS_FT_FI9
Number of Residues23
DetailsTRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:25822790
ChainResidueDetails
RLEU261-LEU284

site_idSWS_FT_FI10
Number of Residues21
DetailsTRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:25822790
ChainResidueDetails
RALA304-PHE325

site_idSWS_FT_FI11
Number of Residues5
DetailsBINDING: BINDING => ECO:0000305|PubMed:25822790, ECO:0007744|PDB:4XNW
ChainResidueDetails
RLYS46
RTYR203
RASN283
RTYR303
RARG310

site_idSWS_FT_FI12
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN11
RASN27
RASN113
RASN197

227111

PDB entries from 2024-11-06

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