Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8W2O

Yeast U1 snRNP with humanized U1C Zinc-Finger domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000243	cellular_component	commitment complex
A	0000395	biological_process	mRNA 5'-splice site recognition
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0003676	molecular_function	nucleic acid binding
A	0003723	molecular_function	RNA binding
A	0003729	molecular_function	mRNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005681	cellular_component	spliceosomal complex
A	0005685	cellular_component	U1 snRNP
A	0006397	biological_process	mRNA processing
A	0008380	biological_process	RNA splicing
A	0030619	molecular_function	U1 snRNA binding
A	0071004	cellular_component	U2-type prespliceosome
A	1990904	cellular_component	ribonucleoprotein complex
B	0000243	cellular_component	commitment complex
B	0000387	biological_process	spliceosomal snRNP assembly
B	0000395	biological_process	mRNA 5'-splice site recognition
B	0000398	biological_process	mRNA splicing, via spliceosome
B	0003676	molecular_function	nucleic acid binding
B	0003723	molecular_function	RNA binding
B	0003729	molecular_function	mRNA binding
B	0005634	cellular_component	nucleus
B	0005681	cellular_component	spliceosomal complex
B	0005685	cellular_component	U1 snRNP
B	0008270	molecular_function	zinc ion binding
B	0030619	molecular_function	U1 snRNA binding
B	0030627	molecular_function	pre-mRNA 5'-splice site binding
B	0046872	molecular_function	metal ion binding
B	0071004	cellular_component	U2-type prespliceosome
B	1990904	cellular_component	ribonucleoprotein complex
C	0000243	cellular_component	commitment complex
C	0000395	biological_process	mRNA 5'-splice site recognition
C	0000398	biological_process	mRNA splicing, via spliceosome
C	0003676	molecular_function	nucleic acid binding
C	0003723	molecular_function	RNA binding
C	0005634	cellular_component	nucleus
C	0005681	cellular_component	spliceosomal complex
C	0005685	cellular_component	U1 snRNP
C	0006397	biological_process	mRNA processing
C	0008380	biological_process	RNA splicing
C	0030619	molecular_function	U1 snRNA binding
C	0071004	cellular_component	U2-type prespliceosome
C	1990904	cellular_component	ribonucleoprotein complex
D	0000243	cellular_component	commitment complex
D	0000395	biological_process	mRNA 5'-splice site recognition
D	0000398	biological_process	mRNA splicing, via spliceosome
D	0003723	molecular_function	RNA binding
D	0005634	cellular_component	nucleus
D	0005681	cellular_component	spliceosomal complex
D	0005685	cellular_component	U1 snRNP
D	0006396	biological_process	RNA processing
D	0006397	biological_process	mRNA processing
D	0008380	biological_process	RNA splicing
D	0030627	molecular_function	pre-mRNA 5'-splice site binding
D	0032991	cellular_component	protein-containing complex
D	0071004	cellular_component	U2-type prespliceosome
D	1990904	cellular_component	ribonucleoprotein complex
E	0000243	cellular_component	commitment complex
E	0000395	biological_process	mRNA 5'-splice site recognition
E	0000398	biological_process	mRNA splicing, via spliceosome
E	0005634	cellular_component	nucleus
E	0005681	cellular_component	spliceosomal complex
E	0005685	cellular_component	U1 snRNP
E	0006396	biological_process	RNA processing
E	0006397	biological_process	mRNA processing
E	0008380	biological_process	RNA splicing
E	0030627	molecular_function	pre-mRNA 5'-splice site binding
E	0032991	cellular_component	protein-containing complex
E	0071004	cellular_component	U2-type prespliceosome
F	0000243	cellular_component	commitment complex
F	0000395	biological_process	mRNA 5'-splice site recognition
F	0000398	biological_process	mRNA splicing, via spliceosome
F	0003676	molecular_function	nucleic acid binding
F	0003723	molecular_function	RNA binding
F	0003729	molecular_function	mRNA binding
F	0005634	cellular_component	nucleus
F	0005681	cellular_component	spliceosomal complex
F	0005685	cellular_component	U1 snRNP
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006376	biological_process	mRNA splice site recognition
F	0006397	biological_process	mRNA processing
F	0008380	biological_process	RNA splicing
F	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
F	0071004	cellular_component	U2-type prespliceosome
G	0000243	cellular_component	commitment complex
G	0000395	biological_process	mRNA 5'-splice site recognition
G	0000398	biological_process	mRNA splicing, via spliceosome
G	0003723	molecular_function	RNA binding
G	0003729	molecular_function	mRNA binding
G	0005634	cellular_component	nucleus
G	0005681	cellular_component	spliceosomal complex
G	0005685	cellular_component	U1 snRNP
G	0006397	biological_process	mRNA processing
G	0008380	biological_process	RNA splicing
G	0071004	cellular_component	U2-type prespliceosome
G	1990904	cellular_component	ribonucleoprotein complex
I	0000243	cellular_component	commitment complex
I	0000395	biological_process	mRNA 5'-splice site recognition
I	0000398	biological_process	mRNA splicing, via spliceosome
I	0003729	molecular_function	mRNA binding
I	0005634	cellular_component	nucleus
I	0005681	cellular_component	spliceosomal complex
I	0005685	cellular_component	U1 snRNP
I	0005829	cellular_component	cytosol
I	0006376	biological_process	mRNA splice site recognition
I	0006397	biological_process	mRNA processing
I	0008270	molecular_function	zinc ion binding
I	0008380	biological_process	RNA splicing
I	0071004	cellular_component	U2-type prespliceosome
I	1990904	cellular_component	ribonucleoprotein complex
K	0000243	cellular_component	commitment complex
K	0000245	biological_process	spliceosomal complex assembly
K	0000387	biological_process	spliceosomal snRNP assembly
K	0000395	biological_process	mRNA 5'-splice site recognition
K	0000398	biological_process	mRNA splicing, via spliceosome
K	0000974	cellular_component	Prp19 complex
K	0003674	molecular_function	molecular_function
K	0003723	molecular_function	RNA binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005681	cellular_component	spliceosomal complex
K	0005682	cellular_component	U5 snRNP
K	0005685	cellular_component	U1 snRNP
K	0005686	cellular_component	U2 snRNP
K	0005687	cellular_component	U4 snRNP
K	0005737	cellular_component	cytoplasm
K	0006397	biological_process	mRNA processing
K	0008380	biological_process	RNA splicing
K	0032991	cellular_component	protein-containing complex
K	0036261	biological_process	7-methylguanosine cap hypermethylation
K	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
K	0070990	molecular_function	snRNP binding
K	0071001	cellular_component	U4/U6 snRNP
K	0071004	cellular_component	U2-type prespliceosome
K	0071013	cellular_component	catalytic step 2 spliceosome
K	1903241	biological_process	U2-type prespliceosome assembly
K	1990904	cellular_component	ribonucleoprotein complex
L	0000243	cellular_component	commitment complex
L	0000245	biological_process	spliceosomal complex assembly
L	0000387	biological_process	spliceosomal snRNP assembly
L	0000395	biological_process	mRNA 5'-splice site recognition
L	0000398	biological_process	mRNA splicing, via spliceosome
L	0000974	cellular_component	Prp19 complex
L	0003723	molecular_function	RNA binding
L	0003729	molecular_function	mRNA binding
L	0005634	cellular_component	nucleus
L	0005681	cellular_component	spliceosomal complex
L	0005682	cellular_component	U5 snRNP
L	0005685	cellular_component	U1 snRNP
L	0005686	cellular_component	U2 snRNP
L	0005687	cellular_component	U4 snRNP
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006396	biological_process	RNA processing
L	0006397	biological_process	mRNA processing
L	0008380	biological_process	RNA splicing
L	0030532	cellular_component	small nuclear ribonucleoprotein complex
L	0034715	cellular_component	pICln-Sm protein complex
L	0034719	cellular_component	SMN-Sm protein complex
L	0036261	biological_process	7-methylguanosine cap hypermethylation
L	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
L	0071001	cellular_component	U4/U6 snRNP
L	0071004	cellular_component	U2-type prespliceosome
L	0071011	cellular_component	precatalytic spliceosome
L	0071013	cellular_component	catalytic step 2 spliceosome
L	0097525	cellular_component	spliceosomal snRNP complex
L	0097526	cellular_component	spliceosomal tri-snRNP complex
L	1903241	biological_process	U2-type prespliceosome assembly
L	1990904	cellular_component	ribonucleoprotein complex
M	0000243	cellular_component	commitment complex
M	0000245	biological_process	spliceosomal complex assembly
M	0000387	biological_process	spliceosomal snRNP assembly
M	0000395	biological_process	mRNA 5'-splice site recognition
M	0000398	biological_process	mRNA splicing, via spliceosome
M	0000974	cellular_component	Prp19 complex
M	0003674	molecular_function	molecular_function
M	0003723	molecular_function	RNA binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005681	cellular_component	spliceosomal complex
M	0005682	cellular_component	U5 snRNP
M	0005685	cellular_component	U1 snRNP
M	0005686	cellular_component	U2 snRNP
M	0005687	cellular_component	U4 snRNP
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0006397	biological_process	mRNA processing
M	0008150	biological_process	biological_process
M	0008380	biological_process	RNA splicing
M	0030532	cellular_component	small nuclear ribonucleoprotein complex
M	0034715	cellular_component	pICln-Sm protein complex
M	0036261	biological_process	7-methylguanosine cap hypermethylation
M	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
M	0071001	cellular_component	U4/U6 snRNP
M	0071004	cellular_component	U2-type prespliceosome
M	0071011	cellular_component	precatalytic spliceosome
M	0071013	cellular_component	catalytic step 2 spliceosome
M	1903241	biological_process	U2-type prespliceosome assembly
M	1990904	cellular_component	ribonucleoprotein complex
N	0000243	cellular_component	commitment complex
N	0000245	biological_process	spliceosomal complex assembly
N	0000387	biological_process	spliceosomal snRNP assembly
N	0000395	biological_process	mRNA 5'-splice site recognition
N	0000398	biological_process	mRNA splicing, via spliceosome
N	0000974	cellular_component	Prp19 complex
N	0003723	molecular_function	RNA binding
N	0003729	molecular_function	mRNA binding
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005681	cellular_component	spliceosomal complex
N	0005682	cellular_component	U5 snRNP
N	0005685	cellular_component	U1 snRNP
N	0005686	cellular_component	U2 snRNP
N	0005687	cellular_component	U4 snRNP
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0006396	biological_process	RNA processing
N	0006397	biological_process	mRNA processing
N	0008380	biological_process	RNA splicing
N	0034719	cellular_component	SMN-Sm protein complex
N	0036261	biological_process	7-methylguanosine cap hypermethylation
N	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
N	0071001	cellular_component	U4/U6 snRNP
N	0071004	cellular_component	U2-type prespliceosome
N	0071011	cellular_component	precatalytic spliceosome
N	0071013	cellular_component	catalytic step 2 spliceosome
N	0097526	cellular_component	spliceosomal tri-snRNP complex
N	1903241	biological_process	U2-type prespliceosome assembly
N	1990904	cellular_component	ribonucleoprotein complex
O	0000243	cellular_component	commitment complex
O	0000245	biological_process	spliceosomal complex assembly
O	0000387	biological_process	spliceosomal snRNP assembly
O	0000395	biological_process	mRNA 5'-splice site recognition
O	0000398	biological_process	mRNA splicing, via spliceosome
O	0003723	molecular_function	RNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005681	cellular_component	spliceosomal complex
O	0005682	cellular_component	U5 snRNP
O	0005685	cellular_component	U1 snRNP
O	0005686	cellular_component	U2 snRNP
O	0005687	cellular_component	U4 snRNP
O	0005737	cellular_component	cytoplasm
O	0006397	biological_process	mRNA processing
O	0008380	biological_process	RNA splicing
O	0032991	cellular_component	protein-containing complex
O	0034715	cellular_component	pICln-Sm protein complex
O	0036261	biological_process	7-methylguanosine cap hypermethylation
O	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
O	0071001	cellular_component	U4/U6 snRNP
O	0071004	cellular_component	U2-type prespliceosome
O	0071011	cellular_component	precatalytic spliceosome
O	1903241	biological_process	U2-type prespliceosome assembly
O	1990904	cellular_component	ribonucleoprotein complex
O	1990935	molecular_function	splicing factor binding
P	0000243	cellular_component	commitment complex
P	0000245	biological_process	spliceosomal complex assembly
P	0000387	biological_process	spliceosomal snRNP assembly
P	0000395	biological_process	mRNA 5'-splice site recognition
P	0000398	biological_process	mRNA splicing, via spliceosome
P	0000974	cellular_component	Prp19 complex
P	0003723	molecular_function	RNA binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005681	cellular_component	spliceosomal complex
P	0005682	cellular_component	U5 snRNP
P	0005685	cellular_component	U1 snRNP
P	0005686	cellular_component	U2 snRNP
P	0005687	cellular_component	U4 snRNP
P	0005737	cellular_component	cytoplasm
P	0006397	biological_process	mRNA processing
P	0008266	molecular_function	poly(U) RNA binding
P	0008380	biological_process	RNA splicing
P	0034715	cellular_component	pICln-Sm protein complex
P	0036261	biological_process	7-methylguanosine cap hypermethylation
P	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
P	0071001	cellular_component	U4/U6 snRNP
P	0071013	cellular_component	catalytic step 2 spliceosome
P	0120114	cellular_component	Sm-like protein family complex
P	1903241	biological_process	U2-type prespliceosome assembly
P	1990904	cellular_component	ribonucleoprotein complex
P	1990935	molecular_function	splicing factor binding
Q	0000243	cellular_component	commitment complex
Q	0000245	biological_process	spliceosomal complex assembly
Q	0000387	biological_process	spliceosomal snRNP assembly
Q	0000395	biological_process	mRNA 5'-splice site recognition
Q	0000398	biological_process	mRNA splicing, via spliceosome
Q	0003674	molecular_function	molecular_function
Q	0003723	molecular_function	RNA binding
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005681	cellular_component	spliceosomal complex
Q	0005682	cellular_component	U5 snRNP
Q	0005685	cellular_component	U1 snRNP
Q	0005686	cellular_component	U2 snRNP
Q	0005687	cellular_component	U4 snRNP
Q	0005737	cellular_component	cytoplasm
Q	0006397	biological_process	mRNA processing
Q	0008150	biological_process	biological_process
Q	0008380	biological_process	RNA splicing
Q	0032991	cellular_component	protein-containing complex
Q	0034719	cellular_component	SMN-Sm protein complex
Q	0036261	biological_process	7-methylguanosine cap hypermethylation
Q	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
Q	0071001	cellular_component	U4/U6 snRNP
Q	0071004	cellular_component	U2-type prespliceosome
Q	0071011	cellular_component	precatalytic spliceosome
Q	0071013	cellular_component	catalytic step 2 spliceosome
Q	0097526	cellular_component	spliceosomal tri-snRNP complex
Q	1903241	biological_process	U2-type prespliceosome assembly
Q	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PROSITE/UniProt

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MRDI

Chain	Residue	Details
H	MET1-ILE4

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Zinc finger: {"description":"Matrin-type","evidences":[{"source":"HAMAP-Rule","id":"MF_03153","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	22
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	12
Details	Compositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	64
Details	Repeat: {"description":"HAT 1"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	64
Details	Repeat: {"description":"HAT 2"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	68
Details	Repeat: {"description":"HAT 3"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	68
Details	Repeat: {"description":"HAT 4"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	32
Details	Repeat: {"description":"HAT 5"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	33
Details	Repeat: {"description":"HAT 6"}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	66
Details	Repeat: {"description":"HAT 7"}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	31
Details	Repeat: {"description":"HAT 8"}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	32
Details	Repeat: {"description":"HAT 9"}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	32
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	72
Details	Domain: {"description":"RRM 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00176","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	10
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	171
Details	Domain: {"description":"Sm","evidences":[{"source":"PROSITE-ProRule","id":"PRU01346","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)