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8VSU

Cryo-EM structure of LKB1-STRADalpha-MO25alpha heterocomplex

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0007165biological_processsignal transduction
A0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
A0014823biological_processresponse to activity
A0018105biological_processpeptidyl-serine phosphorylation
A0019900molecular_functionkinase binding
A0030018cellular_componentZ disc
A0030295molecular_functionprotein kinase activator activity
A0032991cellular_componentprotein-containing complex
A0034774cellular_componentsecretory granule lumen
A0035556biological_processintracellular signal transduction
A0043539molecular_functionprotein serine/threonine kinase activator activity
A0070062cellular_componentextracellular exosome
A0071476biological_processcellular hypotonic response
A0071902biological_processpositive regulation of protein serine/threonine kinase activity
A0097066biological_processresponse to thyroid hormone
A1901017biological_processnegative regulation of potassium ion transmembrane transporter activity
A1901380biological_processnegative regulation of potassium ion transmembrane transport
A1902554cellular_componentserine/threonine protein kinase complex
A1904813cellular_componentficolin-1-rich granule lumen
B0004672molecular_functionprotein kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006468biological_processprotein phosphorylation
B0006611biological_processprotein export from nucleus
B0019900molecular_functionkinase binding
B0030295molecular_functionprotein kinase activator activity
B0032147biological_processactivation of protein kinase activity
B0043539molecular_functionprotein serine/threonine kinase activator activity
B0070314biological_processG1 to G0 transition
B0140535cellular_componentintracellular protein-containing complex
B1902554cellular_componentserine/threonine protein kinase complex
C0000287molecular_functionmagnesium ion binding
C0001558biological_processregulation of cell growth
C0001894biological_processtissue homeostasis
C0001944biological_processvasculature development
C0002039molecular_functionp53 binding
C0004674molecular_functionprotein serine/threonine kinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0006338biological_processchromatin remodeling
C0006468biological_processprotein phosphorylation
C0006470biological_processprotein dephosphorylation
C0006914biological_processautophagy
C0006915biological_processapoptotic process
C0006974biological_processDNA damage response
C0007165biological_processsignal transduction
C0007283biological_processspermatogenesis
C0007409biological_processaxonogenesis
C0008285biological_processnegative regulation of cell population proliferation
C0010212biological_processresponse to ionizing radiation
C0010508biological_processpositive regulation of autophagy
C0014823biological_processresponse to activity
C0016020cellular_componentmembrane
C0016310biological_processphosphorylation
C0018107biological_processpeptidyl-threonine phosphorylation
C0030010biological_processestablishment of cell polarity
C0030018cellular_componentZ disc
C0030111biological_processregulation of Wnt signaling pathway
C0030154biological_processcell differentiation
C0030275molecular_functionLRR domain binding
C0030295molecular_functionprotein kinase activator activity
C0030308biological_processnegative regulation of cell growth
C0030511biological_processpositive regulation of transforming growth factor beta receptor signaling pathway
C0032147biological_processactivation of protein kinase activity
C0032991cellular_componentprotein-containing complex
C0033762biological_processresponse to glucagon
C0033993biological_processresponse to lipid
C0034504biological_processprotein localization to nucleus
C0042593biological_processglucose homeostasis
C0043276biological_processanoikis
C0043434biological_processresponse to peptide hormone
C0044024molecular_functionhistone H2AS1 kinase activity
C0044877molecular_functionprotein-containing complex binding
C0045059biological_processpositive thymic T cell selection
C0045722biological_processpositive regulation of gluconeogenesis
C0046777biological_processprotein autophosphorylation
C0046872molecular_functionmetal ion binding
C0048814biological_processregulation of dendrite morphogenesis
C0050772biological_processpositive regulation of axonogenesis
C0050852biological_processT cell receptor signaling pathway
C0051645biological_processGolgi localization
C0051726biological_processregulation of cell cycle
C0051896biological_processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0060767biological_processepithelial cell proliferation involved in prostate gland development
C0060770biological_processnegative regulation of epithelial cell proliferation involved in prostate gland development
C0070062cellular_componentextracellular exosome
C0070314biological_processG1 to G0 transition
C0071493biological_processcellular response to UV-B
C0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
C0090090biological_processnegative regulation of canonical Wnt signaling pathway
C0097066biological_processresponse to thyroid hormone
C0097484biological_processdendrite extension
C0106310molecular_functionprotein serine kinase activity
C0120163biological_processnegative regulation of cold-induced thermogenesis
C0140535cellular_componentintracellular protein-containing complex
C1900182biological_processpositive regulation of protein localization to nucleus
C1901610biological_processpositive regulation of vesicle transport along microtubule
C1901796biological_processregulation of signal transduction by p53 class mediator
C1902554cellular_componentserine/threonine protein kinase complex
C1904262biological_processnegative regulation of TORC1 signaling
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGSYGKVKeVldsetlcr..........RAVK
ChainResidueDetails
CLEU55-LYS78

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvHkDIKpgNLLL
ChainResidueDetails
CILE172-LEU184

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER39
BSER46

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by LKB1 => ECO:0000269|PubMed:12805220
ChainResidueDetails
BTHR329
BTHR419

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
CLYS78

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
CSER31
CSER401

site_idSWS_FT_FI5
Number of Residues9
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18687677
ChainResidueDetails
CLYS44
CLYS48
CLYS96
CLYS97
CLYS296
CLYS311
CLYS416
CLYS423
CLYS431

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:11430832
ChainResidueDetails
CTHR189

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9WTK7
ChainResidueDetails
CSER325

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:12805220
ChainResidueDetails
CTHR336

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by ATM and autocatalysis => ECO:0000269|PubMed:12805220
ChainResidueDetails
CTHR363

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphoserine; by autocatalysis, PKA, PKC/PRKCZ and RPS6KA1 => ECO:0000269|PubMed:18854309
ChainResidueDetails
CSER428

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250
ChainResidueDetails
CCYS430

site_idSWS_FT_FI12
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250
ChainResidueDetails
CCYS418

site_idSWS_FT_FI13
Number of Residues1
DetailsLIPID: S-farnesyl cysteine => ECO:0000250
ChainResidueDetails
CCYS430

225946

PDB entries from 2024-10-09

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