8VMF

Crystal structure of a transition-state mimic of the GSK-3/Axin complex bound to a beta-catenin S45D peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	25
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGNGSFGVVYqAklcdsgelv.........AIKK

Chain	Residue	Details
A	ILE62-LYS86

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site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IcHrDIKpqNLLL

Chain	Residue	Details
A	ILE177-LEU189

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine; by GSK3-beta and HIPK2 => ECO:0000269|PubMed:20307497

Chain	Residue	Details
C	SER37

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by GSK3-beta => ECO:0000269|PubMed:12027456

Chain	Residue	Details
C	THR41
A	LYS85

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:12051714

Chain	Residue	Details
C	ASP45

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:24824780

Chain	Residue	Details
C	LYS49

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