8V6V

Cryo-EM structure of doubly-bound SNF2h-nucleosome complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000786	cellular_component	nucleosome
A	0003677	molecular_function	DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0030527	molecular_function	structural constituent of chromatin
A	0046982	molecular_function	protein heterodimerization activity
B	0000786	cellular_component	nucleosome
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0030527	molecular_function	structural constituent of chromatin
B	0046982	molecular_function	protein heterodimerization activity
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0030527	molecular_function	structural constituent of chromatin
C	0046982	molecular_function	protein heterodimerization activity
D	0000786	cellular_component	nucleosome
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0030527	molecular_function	structural constituent of chromatin
D	0046982	molecular_function	protein heterodimerization activity
E	0000786	cellular_component	nucleosome
E	0003677	molecular_function	DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0030527	molecular_function	structural constituent of chromatin
E	0046982	molecular_function	protein heterodimerization activity
F	0000786	cellular_component	nucleosome
F	0003677	molecular_function	DNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0030527	molecular_function	structural constituent of chromatin
F	0046982	molecular_function	protein heterodimerization activity
G	0000786	cellular_component	nucleosome
G	0003677	molecular_function	DNA binding
G	0005634	cellular_component	nucleus
G	0005694	cellular_component	chromosome
G	0030527	molecular_function	structural constituent of chromatin
G	0046982	molecular_function	protein heterodimerization activity
H	0000786	cellular_component	nucleosome
H	0003677	molecular_function	DNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005694	cellular_component	chromosome
H	0030527	molecular_function	structural constituent of chromatin
H	0046982	molecular_function	protein heterodimerization activity
W	0000183	biological_process	rDNA heterochromatin formation
W	0000785	cellular_component	chromatin
W	0000793	cellular_component	condensed chromosome
W	0001650	cellular_component	fibrillar center
W	0003677	molecular_function	DNA binding
W	0003682	molecular_function	chromatin binding
W	0004386	molecular_function	helicase activity
W	0005515	molecular_function	protein binding
W	0005524	molecular_function	ATP binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005677	cellular_component	chromatin silencing complex
W	0005694	cellular_component	chromosome
W	0005721	cellular_component	pericentric heterochromatin
W	0005730	cellular_component	nucleolus
W	0006275	biological_process	regulation of DNA replication
W	0006281	biological_process	DNA repair
W	0006325	biological_process	chromatin organization
W	0006334	biological_process	nucleosome assembly
W	0006338	biological_process	chromatin remodeling
W	0006346	biological_process	DNA methylation-dependent heterochromatin formation
W	0006352	biological_process	DNA-templated transcription initiation
W	0006355	biological_process	regulation of DNA-templated transcription
W	0006357	biological_process	regulation of transcription by RNA polymerase II
W	0006974	biological_process	DNA damage response
W	0008623	cellular_component	CHRAC
W	0016479	biological_process	negative regulation of transcription by RNA polymerase I
W	0016589	cellular_component	NURF complex
W	0016590	cellular_component	ACF complex
W	0016787	molecular_function	hydrolase activity
W	0016887	molecular_function	ATP hydrolysis activity
W	0031010	cellular_component	ISWI-type complex
W	0031213	cellular_component	RSF complex
W	0031491	molecular_function	nucleosome binding
W	0031507	biological_process	heterochromatin formation
W	0035861	cellular_component	site of double-strand break
W	0042393	molecular_function	histone binding
W	0043596	cellular_component	nuclear replication fork
W	0045740	biological_process	positive regulation of DNA replication
W	0045893	biological_process	positive regulation of DNA-templated transcription
W	0045943	biological_process	positive regulation of transcription by RNA polymerase I
W	0045944	biological_process	positive regulation of transcription by RNA polymerase II
W	0045945	biological_process	positive regulation of transcription by RNA polymerase III
W	0090535	cellular_component	WICH complex
W	0090536	cellular_component	NoRC complex
W	0110016	cellular_component	B-WICH complex
W	0140374	biological_process	antiviral innate immune response
W	0140658	molecular_function	ATP-dependent chromatin remodeler activity
W	0140750	molecular_function	nucleosome array spacer activity
W	0140751	molecular_function	histone octamer slider activity
W	1905213	biological_process	negative regulation of mitotic chromosome condensation
W	1990830	biological_process	cellular response to leukemia inhibitory factor
X	0000183	biological_process	rDNA heterochromatin formation
X	0000785	cellular_component	chromatin
X	0000793	cellular_component	condensed chromosome
X	0001650	cellular_component	fibrillar center
X	0003677	molecular_function	DNA binding
X	0003682	molecular_function	chromatin binding
X	0004386	molecular_function	helicase activity
X	0005515	molecular_function	protein binding
X	0005524	molecular_function	ATP binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005677	cellular_component	chromatin silencing complex
X	0005694	cellular_component	chromosome
X	0005721	cellular_component	pericentric heterochromatin
X	0005730	cellular_component	nucleolus
X	0006275	biological_process	regulation of DNA replication
X	0006281	biological_process	DNA repair
X	0006325	biological_process	chromatin organization
X	0006334	biological_process	nucleosome assembly
X	0006338	biological_process	chromatin remodeling
X	0006346	biological_process	DNA methylation-dependent heterochromatin formation
X	0006352	biological_process	DNA-templated transcription initiation
X	0006355	biological_process	regulation of DNA-templated transcription
X	0006357	biological_process	regulation of transcription by RNA polymerase II
X	0006974	biological_process	DNA damage response
X	0008623	cellular_component	CHRAC
X	0016479	biological_process	negative regulation of transcription by RNA polymerase I
X	0016589	cellular_component	NURF complex
X	0016590	cellular_component	ACF complex
X	0016787	molecular_function	hydrolase activity
X	0016887	molecular_function	ATP hydrolysis activity
X	0031010	cellular_component	ISWI-type complex
X	0031213	cellular_component	RSF complex
X	0031491	molecular_function	nucleosome binding
X	0031507	biological_process	heterochromatin formation
X	0035861	cellular_component	site of double-strand break
X	0042393	molecular_function	histone binding
X	0043596	cellular_component	nuclear replication fork
X	0045740	biological_process	positive regulation of DNA replication
X	0045893	biological_process	positive regulation of DNA-templated transcription
X	0045943	biological_process	positive regulation of transcription by RNA polymerase I
X	0045944	biological_process	positive regulation of transcription by RNA polymerase II
X	0045945	biological_process	positive regulation of transcription by RNA polymerase III
X	0090535	cellular_component	WICH complex
X	0090536	cellular_component	NoRC complex
X	0110016	cellular_component	B-WICH complex
X	0140374	biological_process	antiviral innate immune response
X	0140658	molecular_function	ATP-dependent chromatin remodeler activity
X	0140750	molecular_function	nucleosome array spacer activity
X	0140751	molecular_function	histone octamer slider activity
X	1905213	biological_process	negative regulation of mitotic chromosome condensation
X	1990830	biological_process	cellular response to leukemia inhibitory factor

Functional Information from PROSITE/UniProt

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
C	ALA21-VAL27

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site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
B	GLY14-HIS18

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site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
A	LYS14-LEU20

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site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
D	ARG89-GLY111

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site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
A	PRO66-ILE74

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
W	ASP205
X	ASP205
D	LYS12
D	LYS17
H	LYS2
H	LYS9
H	LYS12
H	LYS17

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N-acetylserine => ECO:0007744|PubMed:19413330

Chain	Residue	Details
W	SER2
X	SER2

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17693683, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:24275569

Chain	Residue	Details
W	SER66
X	SER66
G	LYS9
G	LYS95

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
W	THR113
X	THR113
H	LYS117

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
W	SER116
X	SER116
G	LYS74
G	LYS75
F	LYS8
F	LYS16
F	LYS44
F	LYS79

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
W	SER137
X	SER137
F	LYS12
F	LYS20

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
W	SER171
W	SER755
X	SER171
X	SER755

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
W	LYS440
X	LYS440
C	LYS15
C	LYS119
G	LYS13
G	LYS15
G	LYS119

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692

Chain	Residue	Details
W	SER825
X	SER825
F	TYR51
F	TYR88

---

site_id	SWS_FT_FI10
Number of Residues	16
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
W	LYS83
E	LYS64
X	LYS644
X	LYS647
X	LYS694
X	LYS722
X	LYS735
X	LYS966
F	LYS59
W	LYS644
W	LYS647
W	LYS694
W	LYS722
W	LYS735
W	LYS966
X	LYS83

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
B	LYS77
F	LYS77

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
B	LYS31
F	LYS31

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
A	LYS37
B	LYS91
F	LYS91

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
A	TYR41
E	TYR41

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P84228

Chain	Residue	Details
A	LYS56
A	LYS79
E	LYS56
E	LYS79

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
A	SER57
E	SER57

---

site_id	SWS_FT_FI17
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
A	THR80
A	THR107
E	THR80
E	THR107

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P84243

Chain	Residue	Details
A	SER86
E	SER86

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
A	LYS115
E	LYS115

---

site_id	SWS_FT_FI20
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
A	LYS122
E	LYS122

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
A	ALA110
E	ALA110

---