8UWB
Crystal structure of PP2A PPP2R1A-PPP2CA-PPP2R5E phosphatase.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0000159 | cellular_component | protein phosphatase type 2A complex |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0007165 | biological_process | signal transduction |
| B | 0019888 | molecular_function | protein phosphatase regulator activity |
| B | 0072542 | molecular_function | protein phosphatase activator activity |
| C | 0004722 | molecular_function | protein serine/threonine phosphatase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| E | 0000159 | cellular_component | protein phosphatase type 2A complex |
| E | 0005515 | molecular_function | protein binding |
| E | 0005634 | cellular_component | nucleus |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0007165 | biological_process | signal transduction |
| E | 0019888 | molecular_function | protein phosphatase regulator activity |
| E | 0072542 | molecular_function | protein phosphatase activator activity |
| F | 0004722 | molecular_function | protein serine/threonine phosphatase activity |
| F | 0016787 | molecular_function | hydrolase activity |
Functional Information from PROSITE/UniProt
| site_id | PS00125 |
| Number of Residues | 6 |
| Details | SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE |
| Chain | Residue | Details |
| C | LEU114-GLU119 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:P36873 |
| Chain | Residue | Details |
| C | HIS118 | |
| F | HIS118 | |
| D | TYR495 | |
| D | HIS497 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17055435, ECO:0000269|PubMed:33633399, ECO:0007744|PDB:7K36 |
| Chain | Residue | Details |
| C | ASP57 | |
| F | ASN117 | |
| F | HIS167 | |
| F | HIS241 | |
| C | HIS59 | |
| C | ASP85 | |
| C | ASN117 | |
| C | HIS167 | |
| C | HIS241 | |
| F | ASP57 | |
| F | HIS59 | |
| F | ASP85 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P67774 |
| Chain | Residue | Details |
| C | TYR307 | |
| F | TYR307 | |
| B | SER34 | |
| E | SER30 | |
| E | SER32 | |
| E | SER34 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Leucine methyl ester => ECO:0000269|PubMed:8206937 |
| Chain | Residue | Details |
| C | LEU309 | |
| F | LEU309 |
