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8UQO

PLCb3-Gbg-Gaq complex on membranes

Functional Information from GO Data
ChainGOidnamespacecontents
A0001508biological_processaction potential
A0001664molecular_functionG protein-coupled receptor binding
A0001750cellular_componentphotoreceptor outer segment
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005096molecular_functionGTPase activator activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005765cellular_componentlysosomal membrane
A0005794cellular_componentGolgi apparatus
A0005834cellular_componentheterotrimeric G-protein complex
A0005886cellular_componentplasma membrane
A0006469biological_processnegative regulation of protein kinase activity
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
A0007202biological_processobsolete activation of phospholipase C activity
A0007206biological_processphospholipase C-activating G protein-coupled glutamate receptor signaling pathway
A0007208biological_processphospholipase C-activating serotonin receptor signaling pathway
A0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
A0007215biological_processglutamate receptor signaling pathway
A0007218biological_processneuropeptide signaling pathway
A0007596biological_processblood coagulation
A0007603biological_processphototransduction, visible light
A0009649biological_processentrainment of circadian clock
A0010543biological_processregulation of platelet activation
A0016787molecular_functionhydrolase activity
A0019001molecular_functionguanyl nucleotide binding
A0030234molecular_functionenzyme regulator activity
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0031965cellular_componentnuclear membrane
A0034695biological_processresponse to prostaglandin E
A0045202cellular_componentsynapse
A0046872molecular_functionmetal ion binding
A0050821biological_processprotein stabilization
A0060158biological_processphospholipase C-activating dopamine receptor signaling pathway
A0060828biological_processregulation of canonical Wnt signaling pathway
A0070062cellular_componentextracellular exosome
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
C0001750cellular_componentphotoreceptor outer segment
C0003924molecular_functionGTPase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005765cellular_componentlysosomal membrane
C0005829cellular_componentcytosol
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
C0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
C0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
C0007265biological_processRas protein signal transduction
C0008283biological_processcell population proliferation
C0016020cellular_componentmembrane
C0030159molecular_functionsignaling receptor complex adaptor activity
C0044877molecular_functionprotein-containing complex binding
C0045202cellular_componentsynapse
C0050909biological_processsensory perception of taste
C0051020molecular_functionGTPase binding
C0060041biological_processretina development in camera-type eye
C0070062cellular_componentextracellular exosome
C0071380biological_processcellular response to prostaglandin E stimulus
C0071870biological_processcellular response to catecholamine stimulus
C0097381cellular_componentphotoreceptor disc membrane
C1903561cellular_componentextracellular vesicle
D0005515molecular_functionprotein binding
D0005834cellular_componentheterotrimeric G-protein complex
D0005886cellular_componentplasma membrane
D0007165biological_processsignal transduction
D0007186biological_processG protein-coupled receptor signaling pathway
D0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
D0016020cellular_componentmembrane
D0031681molecular_functionG-protein beta-subunit binding
D0045202cellular_componentsynapse
D0048144biological_processfibroblast proliferation
D0070062cellular_componentextracellular exosome
D0071380biological_processcellular response to prostaglandin E stimulus
D0071870biological_processcellular response to catecholamine stimulus
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0045202cellular_componentsynapse
G0048144biological_processfibroblast proliferation
G0070062cellular_componentextracellular exosome
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
Q0003073biological_processregulation of systemic arterial blood pressure
Q0004435molecular_functionphosphatidylinositol phospholipase C activity
Q0004629molecular_functionphospholipase C activity
Q0005509molecular_functioncalcium ion binding
Q0005515molecular_functionprotein binding
Q0005516molecular_functioncalmodulin binding
Q0005634cellular_componentnucleus
Q0005737cellular_componentcytoplasm
Q0005829cellular_componentcytosol
Q0006629biological_processlipid metabolic process
Q0007165biological_processsignal transduction
Q0007186biological_processG protein-coupled receptor signaling pathway
Q0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
Q0007208biological_processphospholipase C-activating serotonin receptor signaling pathway
Q0008081molecular_functionphosphoric diester hydrolase activity
Q0016020cellular_componentmembrane
Q0016042biological_processlipid catabolic process
Q0016787molecular_functionhydrolase activity
Q0032991cellular_componentprotein-containing complex
Q0035556biological_processintracellular signal transduction
Q0045296molecular_functioncadherin binding
Q0046488biological_processphosphatidylinositol metabolic process
Q0048015biological_processphosphatidylinositol-mediated signaling
Q0051209biological_processrelease of sequestered calcium ion into cytosol
Q0060090molecular_functionmolecular adaptor activity
Q0099524cellular_componentpostsynaptic cytosol
Q0140677molecular_functionmolecular function activator activity
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
DALA2
GALA2

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
DCYS68
GCYS68
ATHR186
AASN274
AALA331

site_idSWS_FT_FI3
Number of Residues2
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
DCYS68
GCYS68

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
QSER537
ACYS10

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
QSER926

224201

PDB entries from 2024-08-28

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