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8UQ5

Structure of human RyR2-S2808D in the primed state in the presence of Rapamycin

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0001666biological_processresponse to hypoxia
A0002027biological_processregulation of heart rate
A0003143biological_processembryonic heart tube morphogenesis
A0003220biological_processleft ventricular cardiac muscle tissue morphogenesis
A0003300biological_processcardiac muscle hypertrophy
A0005216molecular_functionmonoatomic ion channel activity
A0005219molecular_functionryanodine-sensitive calcium-release channel activity
A0005262molecular_functioncalcium channel activity
A0005509molecular_functioncalcium ion binding
A0005513biological_processdetection of calcium ion
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005790cellular_componentsmooth endoplasmic reticulum
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0006874biological_processintracellular calcium ion homeostasis
A0006941biological_processstriated muscle contraction
A0010460biological_processpositive regulation of heart rate
A0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A0010882biological_processregulation of cardiac muscle contraction by calcium ion signaling
A0014701cellular_componentjunctional sarcoplasmic reticulum membrane
A0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A0014850biological_processresponse to muscle activity
A0015278molecular_functionintracellularly gated calcium channel activity
A0016020cellular_componentmembrane
A0016529cellular_componentsarcoplasmic reticulum
A0019722biological_processcalcium-mediated signaling
A0019899molecular_functionenzyme binding
A0019901molecular_functionprotein kinase binding
A0030017cellular_componentsarcomere
A0030018cellular_componentZ disc
A0031000biological_processresponse to caffeine
A0032991cellular_componentprotein-containing complex
A0033017cellular_componentsarcoplasmic reticulum membrane
A0034236molecular_functionprotein kinase A catalytic subunit binding
A0034237molecular_functionprotein kinase A regulatory subunit binding
A0034704cellular_componentcalcium channel complex
A0035994biological_processresponse to muscle stretch
A0042383cellular_componentsarcolemma
A0042802molecular_functionidentical protein binding
A0043924molecular_functionsuramin binding
A0044325molecular_functiontransmembrane transporter binding
A0048763molecular_functioncalcium-induced calcium release activity
A0051209biological_processrelease of sequestered calcium ion into cytosol
A0051284biological_processpositive regulation of sequestering of calcium ion
A0051480biological_processregulation of cytosolic calcium ion concentration
A0051649biological_processestablishment of localization in cell
A0051775biological_processresponse to redox state
A0055085biological_processtransmembrane transport
A0055117biological_processregulation of cardiac muscle contraction
A0060048biological_processcardiac muscle contraction
A0060402biological_processcalcium ion transport into cytosol
A0070296biological_processsarcoplasmic reticulum calcium ion transport
A0070588biological_processcalcium ion transmembrane transport
A0071313biological_processcellular response to caffeine
A0071872biological_processcellular response to epinephrine stimulus
A0072599biological_processestablishment of protein localization to endoplasmic reticulum
A0086005biological_processventricular cardiac muscle cell action potential
A0086029biological_processPurkinje myocyte to ventricular cardiac muscle cell signaling
A0086064biological_processcell communication by electrical coupling involved in cardiac conduction
A0097050biological_processtype B pancreatic cell apoptotic process
A0097159molecular_functionorganic cyclic compound binding
A0097553biological_processcalcium ion transmembrane import into cytosol
A0098735biological_processpositive regulation of the force of heart contraction
A0098904biological_processregulation of AV node cell action potential
A0098907biological_processregulation of SA node cell action potential
A0098910biological_processregulation of atrial cardiac muscle cell action potential
A0098911biological_processregulation of ventricular cardiac muscle cell action potential
B0001666biological_processresponse to hypoxia
B0002027biological_processregulation of heart rate
B0003143biological_processembryonic heart tube morphogenesis
B0003220biological_processleft ventricular cardiac muscle tissue morphogenesis
B0003300biological_processcardiac muscle hypertrophy
B0005216molecular_functionmonoatomic ion channel activity
B0005219molecular_functionryanodine-sensitive calcium-release channel activity
B0005262molecular_functioncalcium channel activity
B0005509molecular_functioncalcium ion binding
B0005513biological_processdetection of calcium ion
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005790cellular_componentsmooth endoplasmic reticulum
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0006874biological_processintracellular calcium ion homeostasis
B0006941biological_processstriated muscle contraction
B0010460biological_processpositive regulation of heart rate
B0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B0010882biological_processregulation of cardiac muscle contraction by calcium ion signaling
B0014701cellular_componentjunctional sarcoplasmic reticulum membrane
B0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B0014850biological_processresponse to muscle activity
B0015278molecular_functionintracellularly gated calcium channel activity
B0016020cellular_componentmembrane
B0016529cellular_componentsarcoplasmic reticulum
B0019722biological_processcalcium-mediated signaling
B0019899molecular_functionenzyme binding
B0019901molecular_functionprotein kinase binding
B0030017cellular_componentsarcomere
B0030018cellular_componentZ disc
B0031000biological_processresponse to caffeine
B0032991cellular_componentprotein-containing complex
B0033017cellular_componentsarcoplasmic reticulum membrane
B0034236molecular_functionprotein kinase A catalytic subunit binding
B0034237molecular_functionprotein kinase A regulatory subunit binding
B0034704cellular_componentcalcium channel complex
B0035994biological_processresponse to muscle stretch
B0042383cellular_componentsarcolemma
B0042802molecular_functionidentical protein binding
B0043924molecular_functionsuramin binding
B0044325molecular_functiontransmembrane transporter binding
B0048763molecular_functioncalcium-induced calcium release activity
B0051209biological_processrelease of sequestered calcium ion into cytosol
B0051284biological_processpositive regulation of sequestering of calcium ion
B0051480biological_processregulation of cytosolic calcium ion concentration
B0051649biological_processestablishment of localization in cell
B0051775biological_processresponse to redox state
B0055085biological_processtransmembrane transport
B0055117biological_processregulation of cardiac muscle contraction
B0060048biological_processcardiac muscle contraction
B0060402biological_processcalcium ion transport into cytosol
B0070296biological_processsarcoplasmic reticulum calcium ion transport
B0070588biological_processcalcium ion transmembrane transport
B0071313biological_processcellular response to caffeine
B0071872biological_processcellular response to epinephrine stimulus
B0072599biological_processestablishment of protein localization to endoplasmic reticulum
B0086005biological_processventricular cardiac muscle cell action potential
B0086029biological_processPurkinje myocyte to ventricular cardiac muscle cell signaling
B0086064biological_processcell communication by electrical coupling involved in cardiac conduction
B0097050biological_processtype B pancreatic cell apoptotic process
B0097159molecular_functionorganic cyclic compound binding
B0097553biological_processcalcium ion transmembrane import into cytosol
B0098735biological_processpositive regulation of the force of heart contraction
B0098904biological_processregulation of AV node cell action potential
B0098907biological_processregulation of SA node cell action potential
B0098910biological_processregulation of atrial cardiac muscle cell action potential
B0098911biological_processregulation of ventricular cardiac muscle cell action potential
C0001666biological_processresponse to hypoxia
C0002027biological_processregulation of heart rate
C0003143biological_processembryonic heart tube morphogenesis
C0003220biological_processleft ventricular cardiac muscle tissue morphogenesis
C0003300biological_processcardiac muscle hypertrophy
C0005216molecular_functionmonoatomic ion channel activity
C0005219molecular_functionryanodine-sensitive calcium-release channel activity
C0005262molecular_functioncalcium channel activity
C0005509molecular_functioncalcium ion binding
C0005513biological_processdetection of calcium ion
C0005515molecular_functionprotein binding
C0005516molecular_functioncalmodulin binding
C0005790cellular_componentsmooth endoplasmic reticulum
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0006874biological_processintracellular calcium ion homeostasis
C0006941biological_processstriated muscle contraction
C0010460biological_processpositive regulation of heart rate
C0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C0010882biological_processregulation of cardiac muscle contraction by calcium ion signaling
C0014701cellular_componentjunctional sarcoplasmic reticulum membrane
C0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C0014850biological_processresponse to muscle activity
C0015278molecular_functionintracellularly gated calcium channel activity
C0016020cellular_componentmembrane
C0016529cellular_componentsarcoplasmic reticulum
C0019722biological_processcalcium-mediated signaling
C0019899molecular_functionenzyme binding
C0019901molecular_functionprotein kinase binding
C0030017cellular_componentsarcomere
C0030018cellular_componentZ disc
C0031000biological_processresponse to caffeine
C0032991cellular_componentprotein-containing complex
C0033017cellular_componentsarcoplasmic reticulum membrane
C0034236molecular_functionprotein kinase A catalytic subunit binding
C0034237molecular_functionprotein kinase A regulatory subunit binding
C0034704cellular_componentcalcium channel complex
C0035994biological_processresponse to muscle stretch
C0042383cellular_componentsarcolemma
C0042802molecular_functionidentical protein binding
C0043924molecular_functionsuramin binding
C0044325molecular_functiontransmembrane transporter binding
C0048763molecular_functioncalcium-induced calcium release activity
C0051209biological_processrelease of sequestered calcium ion into cytosol
C0051284biological_processpositive regulation of sequestering of calcium ion
C0051480biological_processregulation of cytosolic calcium ion concentration
C0051649biological_processestablishment of localization in cell
C0051775biological_processresponse to redox state
C0055085biological_processtransmembrane transport
C0055117biological_processregulation of cardiac muscle contraction
C0060048biological_processcardiac muscle contraction
C0060402biological_processcalcium ion transport into cytosol
C0070296biological_processsarcoplasmic reticulum calcium ion transport
C0070588biological_processcalcium ion transmembrane transport
C0071313biological_processcellular response to caffeine
C0071872biological_processcellular response to epinephrine stimulus
C0072599biological_processestablishment of protein localization to endoplasmic reticulum
C0086005biological_processventricular cardiac muscle cell action potential
C0086029biological_processPurkinje myocyte to ventricular cardiac muscle cell signaling
C0086064biological_processcell communication by electrical coupling involved in cardiac conduction
C0097050biological_processtype B pancreatic cell apoptotic process
C0097159molecular_functionorganic cyclic compound binding
C0097553biological_processcalcium ion transmembrane import into cytosol
C0098735biological_processpositive regulation of the force of heart contraction
C0098904biological_processregulation of AV node cell action potential
C0098907biological_processregulation of SA node cell action potential
C0098910biological_processregulation of atrial cardiac muscle cell action potential
C0098911biological_processregulation of ventricular cardiac muscle cell action potential
D0001666biological_processresponse to hypoxia
D0002027biological_processregulation of heart rate
D0003143biological_processembryonic heart tube morphogenesis
D0003220biological_processleft ventricular cardiac muscle tissue morphogenesis
D0003300biological_processcardiac muscle hypertrophy
D0005216molecular_functionmonoatomic ion channel activity
D0005219molecular_functionryanodine-sensitive calcium-release channel activity
D0005262molecular_functioncalcium channel activity
D0005509molecular_functioncalcium ion binding
D0005513biological_processdetection of calcium ion
D0005515molecular_functionprotein binding
D0005516molecular_functioncalmodulin binding
D0005790cellular_componentsmooth endoplasmic reticulum
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0006874biological_processintracellular calcium ion homeostasis
D0006941biological_processstriated muscle contraction
D0010460biological_processpositive regulation of heart rate
D0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
D0010882biological_processregulation of cardiac muscle contraction by calcium ion signaling
D0014701cellular_componentjunctional sarcoplasmic reticulum membrane
D0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D0014850biological_processresponse to muscle activity
D0015278molecular_functionintracellularly gated calcium channel activity
D0016020cellular_componentmembrane
D0016529cellular_componentsarcoplasmic reticulum
D0019722biological_processcalcium-mediated signaling
D0019899molecular_functionenzyme binding
D0019901molecular_functionprotein kinase binding
D0030017cellular_componentsarcomere
D0030018cellular_componentZ disc
D0031000biological_processresponse to caffeine
D0032991cellular_componentprotein-containing complex
D0033017cellular_componentsarcoplasmic reticulum membrane
D0034236molecular_functionprotein kinase A catalytic subunit binding
D0034237molecular_functionprotein kinase A regulatory subunit binding
D0034704cellular_componentcalcium channel complex
D0035994biological_processresponse to muscle stretch
D0042383cellular_componentsarcolemma
D0042802molecular_functionidentical protein binding
D0043924molecular_functionsuramin binding
D0044325molecular_functiontransmembrane transporter binding
D0048763molecular_functioncalcium-induced calcium release activity
D0051209biological_processrelease of sequestered calcium ion into cytosol
D0051284biological_processpositive regulation of sequestering of calcium ion
D0051480biological_processregulation of cytosolic calcium ion concentration
D0051649biological_processestablishment of localization in cell
D0051775biological_processresponse to redox state
D0055085biological_processtransmembrane transport
D0055117biological_processregulation of cardiac muscle contraction
D0060048biological_processcardiac muscle contraction
D0060402biological_processcalcium ion transport into cytosol
D0070296biological_processsarcoplasmic reticulum calcium ion transport
D0070588biological_processcalcium ion transmembrane transport
D0071313biological_processcellular response to caffeine
D0071872biological_processcellular response to epinephrine stimulus
D0072599biological_processestablishment of protein localization to endoplasmic reticulum
D0086005biological_processventricular cardiac muscle cell action potential
D0086029biological_processPurkinje myocyte to ventricular cardiac muscle cell signaling
D0086064biological_processcell communication by electrical coupling involved in cardiac conduction
D0097050biological_processtype B pancreatic cell apoptotic process
D0097159molecular_functionorganic cyclic compound binding
D0097553biological_processcalcium ion transmembrane import into cytosol
D0098735biological_processpositive regulation of the force of heart contraction
D0098904biological_processregulation of AV node cell action potential
D0098907biological_processregulation of SA node cell action potential
D0098910biological_processregulation of atrial cardiac muscle cell action potential
D0098911biological_processregulation of ventricular cardiac muscle cell action potential
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues17504
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-THR4281
AGLY4871-ASN4967
BMET1-THR4281
BGLY4871-ASN4967
CMET1-THR4281
CGLY4871-ASN4967
DMET1-THR4281
DGLY4871-ASN4967

site_idSWS_FT_FI2
Number of Residues480
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
AALA4282-PHE4302
BVAL4730-PHE4750
BLEU4769-PHE4789
BPHE4850-PHE4870
CALA4282-PHE4302
CMET4504-THR4524
CTHR4580-PHE4600
CVAL4730-PHE4750
CLEU4769-PHE4789
CPHE4850-PHE4870
DALA4282-PHE4302
AMET4504-THR4524
DMET4504-THR4524
DTHR4580-PHE4600
DVAL4730-PHE4750
DLEU4769-PHE4789
DPHE4850-PHE4870
ATHR4580-PHE4600
AVAL4730-PHE4750
ALEU4769-PHE4789
APHE4850-PHE4870
BALA4282-PHE4302
BMET4504-THR4524
BTHR4580-PHE4600

site_idSWS_FT_FI3
Number of Residues36
DetailsINTRAMEM: Pore-forming => ECO:0000250
ChainResidueDetails
AGLY4820-ASP4829
BGLY4820-ASP4829
CGLY4820-ASP4829
DGLY4820-ASP4829

site_idSWS_FT_FI4
Number of Residues20
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:E9Q401
ChainResidueDetails
ASER1341
BSER2947
CSER1341
CSER2369
CSER2797
CSER2811
CSER2947
DSER1341
DSER2369
DSER2797
DSER2811
ASER2369
DSER2947
ASER2797
ASER2811
ASER2947
BSER1341
BSER2369
BSER2797
BSER2811

site_idSWS_FT_FI5
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:B0LPN4
ChainResidueDetails
ASER1869
ASER2697
BSER1869
BSER2697
CSER1869
CSER2697
DSER1869
DSER2697

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000250|UniProtKB:E9Q401
ChainResidueDetails
ASER2031
BSER2031
CSER2031
DSER2031

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphoserine; by CaMK2D and PKA => ECO:0000269|PubMed:10830164, ECO:0000269|PubMed:20056922
ChainResidueDetails
AASP2808
BASP2808
CASP2808
DASP2808

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphoserine; by CaMK2D => ECO:0000269|PubMed:20056922
ChainResidueDetails
ASER2814
BSER2814
CSER2814
DSER2814

227344

PDB entries from 2024-11-13

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