8UHW

The structure of the Clostridium thermocellum AdhE spirosome

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
A	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
A	0005829	cellular_component	cytosol
A	0006066	biological_process	alcohol metabolic process
A	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
A	0008774	molecular_function	acetaldehyde dehydrogenase (acetylating) activity
A	0015976	biological_process	carbon utilization
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0018455	molecular_function	alcohol dehydrogenase [NAD(P)+] activity
A	0046872	molecular_function	metal ion binding
A	1990002	molecular_function	methylglyoxal reductase (NADPH) (acetol producing) activity
A	1990362	molecular_function	butanol dehydrogenase (NAD+) activity
B	0003824	molecular_function	catalytic activity
B	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
B	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
B	0005829	cellular_component	cytosol
B	0006066	biological_process	alcohol metabolic process
B	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
B	0008774	molecular_function	acetaldehyde dehydrogenase (acetylating) activity
B	0015976	biological_process	carbon utilization
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0018455	molecular_function	alcohol dehydrogenase [NAD(P)+] activity
B	0046872	molecular_function	metal ion binding
B	1990002	molecular_function	methylglyoxal reductase (NADPH) (acetol producing) activity
B	1990362	molecular_function	butanol dehydrogenase (NAD+) activity
C	0003824	molecular_function	catalytic activity
C	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
C	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
C	0005829	cellular_component	cytosol
C	0006066	biological_process	alcohol metabolic process
C	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
C	0008774	molecular_function	acetaldehyde dehydrogenase (acetylating) activity
C	0015976	biological_process	carbon utilization
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0018455	molecular_function	alcohol dehydrogenase [NAD(P)+] activity
C	0046872	molecular_function	metal ion binding
C	1990002	molecular_function	methylglyoxal reductase (NADPH) (acetol producing) activity
C	1990362	molecular_function	butanol dehydrogenase (NAD+) activity
D	0003824	molecular_function	catalytic activity
D	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
D	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
D	0005829	cellular_component	cytosol
D	0006066	biological_process	alcohol metabolic process
D	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
D	0008774	molecular_function	acetaldehyde dehydrogenase (acetylating) activity
D	0015976	biological_process	carbon utilization
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0018455	molecular_function	alcohol dehydrogenase [NAD(P)+] activity
D	0046872	molecular_function	metal ion binding
D	1990002	molecular_function	methylglyoxal reductase (NADPH) (acetol producing) activity
D	1990362	molecular_function	butanol dehydrogenase (NAD+) activity
E	0003824	molecular_function	catalytic activity
E	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
E	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
E	0005829	cellular_component	cytosol
E	0006066	biological_process	alcohol metabolic process
E	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
E	0008774	molecular_function	acetaldehyde dehydrogenase (acetylating) activity
E	0015976	biological_process	carbon utilization
E	0016491	molecular_function	oxidoreductase activity
E	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
E	0018455	molecular_function	alcohol dehydrogenase [NAD(P)+] activity
E	0046872	molecular_function	metal ion binding
E	1990002	molecular_function	methylglyoxal reductase (NADPH) (acetol producing) activity
E	1990362	molecular_function	butanol dehydrogenase (NAD+) activity
F	0003824	molecular_function	catalytic activity
F	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
F	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
F	0005829	cellular_component	cytosol
F	0006066	biological_process	alcohol metabolic process
F	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
F	0008774	molecular_function	acetaldehyde dehydrogenase (acetylating) activity
F	0015976	biological_process	carbon utilization
F	0016491	molecular_function	oxidoreductase activity
F	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
F	0018455	molecular_function	alcohol dehydrogenase [NAD(P)+] activity
F	0046872	molecular_function	metal ion binding
F	1990002	molecular_function	methylglyoxal reductase (NADPH) (acetol producing) activity
F	1990362	molecular_function	butanol dehydrogenase (NAD+) activity

Functional Information from PROSITE/UniProt

site_id	PS00060
Number of Residues	21
Details	ADH_IRON_2 Iron-containing alcohol dehydrogenases signature 2. GvCHsmAHkLGAfyhLpHGvA

Chain	Residue	Details
A	GLY727-ALA747

---

site_id	PS00913
Number of Residues	29
Details	ADH_IRON_1 Iron-containing alcohol dehydrogenases signature 1. AIvDadmmmnaPkgltAaSgiDALthalE

Chain	Residue	Details
A	ALA639-GLU667

---