8UDC
Crystal structure of TcPINK1 in complex with CYC116
Functional Information from PROSITE/UniProt
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IaHrDLKsdNLLL |
| Chain | Residue | Details |
| A | ILE333-LEU345 |
| site_id | PS00373 |
| Number of Residues | 24 |
| Details | GART Phosphoribosylglycinamide formyltransferase active site. GlSLpYTsAeMDkGgnTalmapeI |
| Chain | Residue | Details |
| A | GLY370-ILE393 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 449 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | THR121-ASP570 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:29991771 |
| Chain | Residue | Details |
| A | ASP337 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:29991771, ECO:0007744|PDB:5YJ9 |
| Chain | Residue | Details |
| A | LYS196 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29991771, ECO:0007744|PDB:5YJ9 |
| Chain | Residue | Details |
| A | GLU217 | |
| A | LYS295 | |
| A | TYR297 | |
| A | ASN300 | |
| A | ASP341 | |
| A | ASN342 | |
| A | ASP359 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:22645651, ECO:0000269|PubMed:28980524, ECO:0000269|PubMed:29475881, ECO:0000269|PubMed:29991771 |
| Chain | Residue | Details |
| A | SER205 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:29991771 |
| Chain | Residue | Details |
| A | SER377 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:29991771 |
| Chain | Residue | Details |
| A | THR386 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:29991771 |
| Chain | Residue | Details |
| A | THR530 |
