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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8U3C

TRPV1 in nanodisc bound with PI-Br4 bound in Conformation 2 (monomer)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000166molecular_functionnucleotide binding
A0001659biological_processtemperature homeostasis
A0001660biological_processfever generation
A0001774biological_processmicroglial cell activation
A0002024biological_processdiet induced thermogenesis
A0002790biological_processpeptide secretion
A0003085biological_processnegative regulation of systemic arterial blood pressure
A0004888molecular_functiontransmembrane signaling receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0005231molecular_functionexcitatory extracellular ligand-gated monoatomic ion channel activity
A0005261molecular_functionmonoatomic cation channel activity
A0005262molecular_functioncalcium channel activity
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005886cellular_componentplasma membrane
A0006629biological_processlipid metabolic process
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0008015biological_processblood circulation
A0008289molecular_functionlipid binding
A0008324molecular_functionmonoatomic cation transmembrane transporter activity
A0009268biological_processresponse to pH
A0009408biological_processresponse to heat
A0009897cellular_componentexternal side of plasma membrane
A0010459biological_processnegative regulation of heart rate
A0010917biological_processnegative regulation of mitochondrial membrane potential
A0014047biological_processglutamate secretion
A0014832biological_processurinary bladder smooth muscle contraction
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0015278molecular_functionintracellularly gated calcium channel activity
A0016020cellular_componentmembrane
A0017081molecular_functionchloride channel regulator activity
A0019233biological_processsensory perception of pain
A0019722biological_processcalcium-mediated signaling
A0030425cellular_componentdendrite
A0032591cellular_componentdendritic spine membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0034605biological_processcellular response to heat
A0035091molecular_functionphosphatidylinositol binding
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043065biological_processpositive regulation of apoptotic process
A0043434biological_processresponse to peptide hormone
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0045429biological_processpositive regulation of nitric oxide biosynthetic process
A0045907biological_processpositive regulation of vasoconstriction
A0046872molecular_functionmetal ion binding
A0048265biological_processresponse to pain
A0048266biological_processbehavioral response to pain
A0050909biological_processsensory perception of taste
A0050954biological_processsensory perception of mechanical stimulus
A0050955biological_processthermoception
A0050960biological_processdetection of temperature stimulus involved in thermoception
A0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
A0050968biological_processdetection of chemical stimulus involved in sensory perception of pain
A0051219molecular_functionphosphoprotein binding
A0051289biological_processprotein homotetramerization
A0055085biological_processtransmembrane transport
A0060079biological_processexcitatory postsynaptic potential
A0060083biological_processsmooth muscle contraction involved in micturition
A0070588biological_processcalcium ion transmembrane transport
A0071312biological_processcellular response to alkaloid
A0071318biological_processcellular response to ATP
A0071345biological_processcellular response to cytokine stimulus
A0071356biological_processcellular response to tumor necrosis factor
A0071363biological_processcellular response to growth factor stimulus
A0071468biological_processcellular response to acidic pH
A0071502biological_processcellular response to temperature stimulus
A0090212biological_processnegative regulation of establishment of blood-brain barrier
A0097603molecular_functiontemperature-gated ion channel activity
A0098703biological_processcalcium ion import across plasma membrane
A0098982cellular_componentGABA-ergic synapse
A1901594biological_processresponse to capsazepine
A1990090biological_processcellular response to nerve growth factor stimulus
A2000463biological_processpositive regulation of excitatory postsynaptic potential
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000166molecular_functionnucleotide binding
D0001659biological_processtemperature homeostasis
D0001660biological_processfever generation
D0001774biological_processmicroglial cell activation
D0002024biological_processdiet induced thermogenesis
D0002790biological_processpeptide secretion
D0003085biological_processnegative regulation of systemic arterial blood pressure
D0004888molecular_functiontransmembrane signaling receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0005231molecular_functionexcitatory extracellular ligand-gated monoatomic ion channel activity
D0005261molecular_functionmonoatomic cation channel activity
D0005262molecular_functioncalcium channel activity
D0005515molecular_functionprotein binding
D0005516molecular_functioncalmodulin binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005886cellular_componentplasma membrane
D0006629biological_processlipid metabolic process
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0007204biological_processpositive regulation of cytosolic calcium ion concentration
D0008015biological_processblood circulation
D0008289molecular_functionlipid binding
D0008324molecular_functionmonoatomic cation transmembrane transporter activity
D0009268biological_processresponse to pH
D0009408biological_processresponse to heat
D0009897cellular_componentexternal side of plasma membrane
D0010459biological_processnegative regulation of heart rate
D0010917biological_processnegative regulation of mitochondrial membrane potential
D0014047biological_processglutamate secretion
D0014832biological_processurinary bladder smooth muscle contraction
D0015276molecular_functionligand-gated monoatomic ion channel activity
D0015278molecular_functionintracellularly gated calcium channel activity
D0016020cellular_componentmembrane
D0017081molecular_functionchloride channel regulator activity
D0019233biological_processsensory perception of pain
D0019722biological_processcalcium-mediated signaling
D0030425cellular_componentdendrite
D0032591cellular_componentdendritic spine membrane
D0034220biological_processmonoatomic ion transmembrane transport
D0034605biological_processcellular response to heat
D0035091molecular_functionphosphatidylinositol binding
D0042802molecular_functionidentical protein binding
D0042995cellular_componentcell projection
D0043005cellular_componentneuron projection
D0043025cellular_componentneuronal cell body
D0043065biological_processpositive regulation of apoptotic process
D0043434biological_processresponse to peptide hormone
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0045429biological_processpositive regulation of nitric oxide biosynthetic process
D0045907biological_processpositive regulation of vasoconstriction
D0046872molecular_functionmetal ion binding
D0048265biological_processresponse to pain
D0048266biological_processbehavioral response to pain
D0050909biological_processsensory perception of taste
D0050954biological_processsensory perception of mechanical stimulus
D0050955biological_processthermoception
D0050960biological_processdetection of temperature stimulus involved in thermoception
D0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
D0050968biological_processdetection of chemical stimulus involved in sensory perception of pain
D0051219molecular_functionphosphoprotein binding
D0051289biological_processprotein homotetramerization
D0055085biological_processtransmembrane transport
D0060079biological_processexcitatory postsynaptic potential
D0060083biological_processsmooth muscle contraction involved in micturition
D0070588biological_processcalcium ion transmembrane transport
D0071312biological_processcellular response to alkaloid
D0071318biological_processcellular response to ATP
D0071345biological_processcellular response to cytokine stimulus
D0071356biological_processcellular response to tumor necrosis factor
D0071363biological_processcellular response to growth factor stimulus
D0071468biological_processcellular response to acidic pH
D0071502biological_processcellular response to temperature stimulus
D0090212biological_processnegative regulation of establishment of blood-brain barrier
D0097603molecular_functiontemperature-gated ion channel activity
D0098703biological_processcalcium ion import across plasma membrane
D0098982cellular_componentGABA-ergic synapse
D1901594biological_processresponse to capsazepine
D1990090biological_processcellular response to nerve growth factor stimulus
D2000463biological_processpositive regulation of excitatory postsynaptic potential
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues27
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues26
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues44
DetailsIntramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues22
DetailsRepeat: {"description":"ANK 7","evidences":[{"source":"UniProtKB","id":"Q8NER1","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues6
DetailsMotif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"10931826","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q8NER1","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q9R186","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by PKC/PRKCE","evidences":[{"source":"PubMed","id":"11884385","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12194871","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14630912","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"14630912","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues27
DetailsTransmembrane: {"description":"Helical; Name=S5","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues28
DetailsTransmembrane: {"description":"Helical; Name=S6","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

239803

数据于2025-08-06公开中

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