8TLM
Structure of a class A GPCR/Fab complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| C | 0004930 | molecular_function | G protein-coupled receptor activity |
| C | 0004950 | molecular_function | chemokine receptor activity |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006091 | biological_process | generation of precursor metabolites and energy |
| C | 0006935 | biological_process | chemotaxis |
| C | 0006955 | biological_process | immune response |
| C | 0007155 | biological_process | cell adhesion |
| C | 0007165 | biological_process | signal transduction |
| C | 0007166 | biological_process | cell surface receptor signaling pathway |
| C | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| C | 0007204 | biological_process | positive regulation of cytosolic calcium ion concentration |
| C | 0008218 | biological_process | bioluminescence |
| C | 0009897 | cellular_component | external side of plasma membrane |
| C | 0015026 | molecular_function | coreceptor activity |
| C | 0016020 | cellular_component | membrane |
| C | 0016493 | molecular_function | C-C chemokine receptor activity |
| C | 0019722 | biological_process | calcium-mediated signaling |
| C | 0019957 | molecular_function | C-C chemokine binding |
| C | 0060326 | biological_process | cell chemotaxis |
| C | 0070098 | biological_process | chemokine-mediated signaling pathway |
| C | 0071345 | biological_process | cellular response to cytokine stimulus |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSMfFITLMSVDRYLaV |
| Chain | Residue | Details |
| C | SER119-VAL135 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| B | TYR195-HIS201 | |
| A | TYR203-HIS209 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 27 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 25 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 43 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
