8TDO
Cryo-EM structure of cardiac amyloid fibril from a variant ATTR I84S amyloidosis patient-3, variant-type morphology
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11418763, ECO:0007744|PDB:1ICT |
| Chain | Residue | Details |
| A | LYS15 | |
| A | GLU54 | |
| A | SER117 | |
| B | LYS15 | |
| B | GLU54 | |
| B | SER117 | |
| C | LYS15 | |
| C | GLU54 | |
| C | SER117 | |
| E | LYS15 | |
| E | GLU54 | |
| E | SER117 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: Sulfocysteine => ECO:0000269|PubMed:17175208, ECO:0007744|PDB:2H4E |
| Chain | Residue | Details |
| A | CYS10 | |
| B | CYS10 | |
| C | CYS10 | |
| E | CYS10 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: 4-carboxyglutamate; in a patient with Moyamoya disease => ECO:0000269|PubMed:18221012 |
| Chain | Residue | Details |
| A | GLU42 | |
| B | GLU42 | |
| C | GLU42 | |
| E | GLU42 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P02767 |
| Chain | Residue | Details |
| A | SER52 | |
| B | SER52 | |
| C | SER52 | |
| E | SER52 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19167329 |
| Chain | Residue | Details |
| A | ASN98 | |
| B | ASN98 | |
| C | ASN98 | |
| E | ASN98 |
