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8TB0

Cryo-EM Structure of GPR61-G protein complex stabilized by scFv16

Functional Information from GO Data
ChainGOidnamespacecontents
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0045202cellular_componentsynapse
G0048144biological_processfibroblast proliferation
G0070062cellular_componentextracellular exosome
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
R0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
R0003091biological_processrenal water homeostasis
R0003924molecular_functionGTPase activity
R0003925molecular_functionG protein activity
R0004930molecular_functionG protein-coupled receptor activity
R0005506molecular_functioniron ion binding
R0005515molecular_functionprotein binding
R0005525molecular_functionGTP binding
R0005737cellular_componentcytoplasm
R0005768cellular_componentendosome
R0005829cellular_componentcytosol
R0005834cellular_componentheterotrimeric G-protein complex
R0005886cellular_componentplasma membrane
R0007165biological_processsignal transduction
R0007186biological_processG protein-coupled receptor signaling pathway
R0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
R0007190biological_processactivation of adenylate cyclase activity
R0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
R0007608biological_processsensory perception of smell
R0009055molecular_functionelectron transfer activity
R0010008cellular_componentendosome membrane
R0010856molecular_functionadenylate cyclase activator activity
R0016020cellular_componentmembrane
R0016787molecular_functionhydrolase activity
R0019001molecular_functionguanyl nucleotide binding
R0020037molecular_functionheme binding
R0022900biological_processelectron transport chain
R0031683molecular_functionG-protein beta/gamma-subunit complex binding
R0031748molecular_functionD1 dopamine receptor binding
R0032588cellular_componenttrans-Golgi network membrane
R0038035biological_processligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway
R0042597cellular_componentperiplasmic space
R0043235cellular_componentreceptor complex
R0046872molecular_functionmetal ion binding
R0046907biological_processintracellular transport
R0048589biological_processdevelopmental growth
R0050796biological_processregulation of insulin secretion
R0050890biological_processcognition
R0060348biological_processbone development
R0060789biological_processhair follicle placode formation
R0070062cellular_componentextracellular exosome
R0070527biological_processplatelet aggregation
R0071377biological_processcellular response to glucagon stimulus
R0071380biological_processcellular response to prostaglandin E stimulus
R0071870biological_processcellular response to catecholamine stimulus
R0071880biological_processadenylate cyclase-activating adrenergic receptor signaling pathway
R0120162biological_processpositive regulation of cold-induced thermogenesis
R1990763molecular_functionarrestin family protein binding
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. LAIlSVSAINVERYYyV
ChainResidueDetails
RLEU128-VAL144

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
GALA2

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
GCYS68
RILE136-THR155
RSER230-VAL287
RASN345-SER1446

site_idSWS_FT_FI3
Number of Residues1
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
GCYS68

site_idSWS_FT_FI4
Number of Residues53
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
RLEU99-GLU112
RLEU179-GLN206
RALA311-SER324

site_idSWS_FT_FI5
Number of Residues22
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
RVAL113-ALA135

site_idSWS_FT_FI6
Number of Residues22
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
RLEU156-VAL178

site_idSWS_FT_FI7
Number of Residues22
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
RLEU207-CYS229

site_idSWS_FT_FI8
Number of Residues22
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
RVAL288-VAL310

site_idSWS_FT_FI9
Number of Residues19
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
RVAL325-LEU344

site_idSWS_FT_FI10
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:29226084
ChainResidueDetails
RASN12

site_idSWS_FT_FI11
Number of Residues7
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P04896
ChainResidueDetails
RGLY1502
RASN1509
RLEU1652
RTHR1659
RASP1678
RASN1747
RSER1821

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: ADP-ribosylarginine; by cholera toxin => ECO:0000250
ChainResidueDetails
RARG1656

site_idSWS_FT_FI13
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
RSER1807

site_idSWS_FT_FI14
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
ChainResidueDetails
RLYS1755

site_idSWS_FT_FI15
Number of Residues2
DetailsBINDING: axial binding residue
ChainResidueDetails
RTRP-106
RILE-11

223790

PDB entries from 2024-08-14

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