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8T1C

Cryo-EM structure of human TRPV4 ankyrin repeat domain in complex with GTPase RhoA

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001666biological_processresponse to hypoxia
A0002024biological_processdiet induced thermogenesis
A0003779molecular_functionactin binding
A0005034molecular_functionosmosensor activity
A0005080molecular_functionprotein kinase C binding
A0005216molecular_functionmonoatomic ion channel activity
A0005261molecular_functionmonoatomic cation channel activity
A0005262molecular_functioncalcium channel activity
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005524molecular_functionATP binding
A0005783cellular_componentendoplasmic reticulum
A0005881cellular_componentcytoplasmic microtubule
A0005886cellular_componentplasma membrane
A0005912cellular_componentadherens junction
A0005925cellular_componentfocal adhesion
A0005929cellular_componentcilium
A0006091biological_processgeneration of precursor metabolites and energy
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0006874biological_processintracellular calcium ion homeostasis
A0006884biological_processcell volume homeostasis
A0006970biological_processresponse to osmotic stress
A0006971biological_processhypotonic response
A0007015biological_processactin filament organization
A0007043biological_processcell-cell junction assembly
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0007231biological_processosmosensory signaling pathway
A0008017molecular_functionmicrotubule binding
A0008218biological_processbioluminescence
A0008289molecular_functionlipid binding
A0009612biological_processresponse to mechanical stimulus
A0009986cellular_componentcell surface
A0010628biological_processpositive regulation of gene expression
A0010759biological_processpositive regulation of macrophage chemotaxis
A0010977biological_processnegative regulation of neuron projection development
A0015275molecular_functionstretch-activated, monoatomic cation-selective, calcium channel activity
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0019901molecular_functionprotein kinase binding
A0030027cellular_componentlamellipodium
A0030036biological_processactin cytoskeleton organization
A0030103biological_processvasopressin secretion
A0030175cellular_componentfilopodium
A0030426cellular_componentgrowth cone
A0030864cellular_componentcortical actin cytoskeleton
A0031117biological_processpositive regulation of microtubule depolymerization
A0032587cellular_componentruffle membrane
A0032755biological_processpositive regulation of interleukin-6 production
A0032868biological_processresponse to insulin
A0034605biological_processcellular response to heat
A0042169molecular_functionSH2 domain binding
A0042538biological_processhyperosmotic salinity response
A0042593biological_processglucose homeostasis
A0042802molecular_functionidentical protein binding
A0043014molecular_functionalpha-tubulin binding
A0043117biological_processpositive regulation of vascular permeability
A0043622biological_processcortical microtubule organization
A0045989biological_processpositive regulation of striated muscle contraction
A0046330biological_processpositive regulation of JNK cascade
A0046785biological_processmicrotubule polymerization
A0046872molecular_functionmetal ion binding
A0047484biological_processregulation of response to osmotic stress
A0048487molecular_functionbeta-tubulin binding
A0050729biological_processpositive regulation of inflammatory response
A0050891biological_processmulticellular organismal-level water homeostasis
A0051015molecular_functionactin filament binding
A0055085biological_processtransmembrane transport
A0060351biological_processcartilage development involved in endochondral bone morphogenesis
A0070161cellular_componentanchoring junction
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0070509biological_processcalcium ion import
A0070588biological_processcalcium ion transmembrane transport
A0071470biological_processcellular response to osmotic stress
A0071476biological_processcellular hypotonic response
A0071477biological_processcellular hypotonic salinity response
A0071639biological_processpositive regulation of monocyte chemotactic protein-1 production
A0071642biological_processpositive regulation of macrophage inflammatory protein 1 alpha production
A0071651biological_processpositive regulation of chemokine (C-C motif) ligand 5 production
A0097009biological_processenergy homeostasis
A0097497biological_processblood vessel endothelial cell delamination
A1902656biological_processcalcium ion import into cytosol
A1903444biological_processnegative regulation of brown fat cell differentiation
A1903715biological_processregulation of aerobic respiration
A2000340biological_processpositive regulation of chemokine (C-X-C motif) ligand 1 production
E0000902biological_processcell morphogenesis
E0001764biological_processneuron migration
E0001822biological_processkidney development
E0001998biological_processangiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
E0002363biological_processalpha-beta T cell lineage commitment
E0003100biological_processregulation of systemic arterial blood pressure by endothelin
E0003189biological_processaortic valve formation
E0003924molecular_functionGTPase activity
E0003925molecular_functionG protein activity
E0005515molecular_functionprotein binding
E0005525molecular_functionGTP binding
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005768cellular_componentendosome
E0005789cellular_componentendoplasmic reticulum membrane
E0005829cellular_componentcytosol
E0005856cellular_componentcytoskeleton
E0005886cellular_componentplasma membrane
E0005925cellular_componentfocal adhesion
E0005938cellular_componentcell cortex
E0006357biological_processregulation of transcription by RNA polymerase II
E0007010biological_processcytoskeleton organization
E0007155biological_processcell adhesion
E0007160biological_processcell-matrix adhesion
E0007264biological_processsmall GTPase-mediated signal transduction
E0007266biological_processRho protein signal transduction
E0007519biological_processskeletal muscle tissue development
E0009898cellular_componentcytoplasmic side of plasma membrane
E0010812biological_processnegative regulation of cell-substrate adhesion
E0010975biological_processregulation of neuron projection development
E0016477biological_processcell migration
E0016787molecular_functionhydrolase activity
E0017022molecular_functionmyosin binding
E0019901molecular_functionprotein kinase binding
E0021762biological_processsubstantia nigra development
E0021795biological_processcerebral cortex cell migration
E0021861biological_processforebrain radial glial cell differentiation
E0030027cellular_componentlamellipodium
E0030036biological_processactin cytoskeleton organization
E0030054cellular_componentcell junction
E0030154biological_processcell differentiation
E0030334biological_processregulation of cell migration
E0030425cellular_componentdendrite
E0030496cellular_componentmidbody
E0030521biological_processandrogen receptor signaling pathway
E0030667cellular_componentsecretory granule membrane
E0031122biological_processcytoplasmic microtubule organization
E0031982cellular_componentvesicle
E0032154cellular_componentcleavage furrow
E0032467biological_processpositive regulation of cytokinesis
E0032587cellular_componentruffle membrane
E0032956biological_processregulation of actin cytoskeleton organization
E0033144biological_processnegative regulation of intracellular steroid hormone receptor signaling pathway
E0033688biological_processregulation of osteoblast proliferation
E0034329biological_processcell junction assembly
E0034446biological_processsubstrate adhesion-dependent cell spreading
E0035385biological_processRoundabout signaling pathway
E0036089biological_processcleavage furrow formation
E0038027biological_processapolipoprotein A-I-mediated signaling pathway
E0042476biological_processodontogenesis
E0042995cellular_componentcell projection
E0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
E0043149biological_processstress fiber assembly
E0043197cellular_componentdendritic spine
E0043296cellular_componentapical junction complex
E0043297biological_processapical junction assembly
E0043366biological_processbeta selection
E0043542biological_processendothelial cell migration
E0043931biological_processossification involved in bone maturation
E0044319biological_processwound healing, spreading of cells
E0045198biological_processestablishment of epithelial cell apical/basal polarity
E0045666biological_processpositive regulation of neuron differentiation
E0045792biological_processnegative regulation of cell size
E0046638biological_processpositive regulation of alpha-beta T cell differentiation
E0050919biological_processnegative chemotaxis
E0051301biological_processcell division
E0051496biological_processpositive regulation of stress fiber assembly
E0051893biological_processregulation of focal adhesion assembly
E0060071biological_processWnt signaling pathway, planar cell polarity pathway
E0060193biological_processpositive regulation of lipase activity
E0061430biological_processbone trabecula morphogenesis
E0070062cellular_componentextracellular exosome
E0070507biological_processregulation of microtubule cytoskeleton organization
E0071222biological_processcellular response to lipopolysaccharide
E0071345biological_processcellular response to cytokine stimulus
E0071526biological_processsemaphorin-plexin signaling pathway
E0071803biological_processpositive regulation of podosome assembly
E0071902biological_processpositive regulation of protein serine/threonine kinase activity
E0071944cellular_componentcell periphery
E0090051biological_processnegative regulation of cell migration involved in sprouting angiogenesis
E0090307biological_processmitotic spindle assembly
E0090324biological_processnegative regulation of oxidative phosphorylation
E0097049biological_processmotor neuron apoptotic process
E0097498biological_processendothelial tube lumen extension
E0098794cellular_componentpostsynapse
E0098978cellular_componentglutamatergic synapse
E0099159biological_processregulation of modification of postsynaptic structure
E0101003cellular_componentficolin-1-rich granule membrane
E1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
E1902766biological_processskeletal muscle satellite cell migration
E1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
E1903673biological_processmitotic cleavage furrow formation
E1904695biological_processpositive regulation of vascular associated smooth muscle contraction
E1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
E1905274biological_processregulation of modification of postsynaptic actin cytoskeleton
E1990869biological_processcellular response to chemokine
E2000177biological_processregulation of neural precursor cell proliferation
E2000406biological_processpositive regulation of T cell migration
E2000672biological_processnegative regulation of motor neuron apoptotic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:10748207, ECO:0000269|PubMed:12777804
ChainResidueDetails
EGLY12
EASN117
AARG594-LYS608
AGLY723-LEU871

site_idSWS_FT_FI2
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P62820
ChainResidueDetails
EPHE30
EASP59
ESER160
AALA573-THR593
AILE609-LEU636
AVAL694-VAL722

site_idSWS_FT_FI3
Number of Residues1
DetailsSITE: (Microbial infection) Cleavage; by yopT => ECO:0000269|PubMed:12062101, ECO:0000269|PubMed:12538863
ChainResidueDetails
EGLY189
AALA569-GLU572
AASN637-THR665
ALEU686-VAL693

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538
ChainResidueDetails
ETYR34

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103
ChainResidueDetails
ETHR37
ALYS197
AASN201
ATYR236
AARG248

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: (Microbial infection) ADP-ribosylasparagine; by botulinum toxin => ECO:0000305|PubMed:1328215
ChainResidueDetails
EASN41
AASN296
ALYS344

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: 5-glutamyl serotonin => ECO:0000250|UniProtKB:Q9QUI0
ChainResidueDetails
EGLN63

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PKG/PRKG1 => ECO:0000269|PubMed:11162591
ChainResidueDetails
ESER188
ATYR253
ATYR805

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P61585
ChainResidueDetails
ECYS190

site_idSWS_FT_FI10
Number of Residues3
DetailsLIPID: (Microbial infection) N6-stearoyl lysine => ECO:0000269|PubMed:30061757
ChainResidueDetails
ELYS185
ELYS186
ELYS187

site_idSWS_FT_FI11
Number of Residues1
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P61585
ChainResidueDetails
ECYS190

site_idSWS_FT_FI12
Number of Residues1
DetailsCARBOHYD: (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704
ChainResidueDetails
ETYR34

site_idSWS_FT_FI13
Number of Residues1
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate => ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059
ChainResidueDetails
ETHR37

site_idSWS_FT_FI14
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23871831
ChainResidueDetails
ELYS135

222415

PDB entries from 2024-07-10

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