8STW
K384N HUMAN CYSTATHIONINE BETA-SYNTHASE (delta 411-551)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004122 | molecular_function | cystathionine beta-synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006535 | biological_process | cysteine biosynthetic process from serine |
| A | 0019343 | biological_process | cysteine biosynthetic process via cystathionine |
| B | 0004122 | molecular_function | cystathionine beta-synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006535 | biological_process | cysteine biosynthetic process from serine |
| B | 0019343 | biological_process | cysteine biosynthetic process via cystathionine |
| C | 0004122 | molecular_function | cystathionine beta-synthase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006535 | biological_process | cysteine biosynthetic process from serine |
| C | 0019343 | biological_process | cysteine biosynthetic process via cystathionine |
| D | 0004122 | molecular_function | cystathionine beta-synthase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006535 | biological_process | cysteine biosynthetic process from serine |
| D | 0019343 | biological_process | cysteine biosynthetic process via cystathionine |
| E | 0004122 | molecular_function | cystathionine beta-synthase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006535 | biological_process | cysteine biosynthetic process from serine |
| E | 0019343 | biological_process | cysteine biosynthetic process via cystathionine |
| F | 0004122 | molecular_function | cystathionine beta-synthase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006535 | biological_process | cysteine biosynthetic process from serine |
| F | 0019343 | biological_process | cysteine biosynthetic process via cystathionine |
Functional Information from PROSITE/UniProt
| site_id | PS00901 |
| Number of Residues | 19 |
| Details | CYS_SYNTHASE Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. KcEffn.AGgSVKdRiSlrM |
| Chain | Residue | Details |
| A | LYS108-MET126 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: axial binding residue => ECO:0000269|PubMed:11483494, ECO:0000269|PubMed:12173932 |
| Chain | Residue | Details |
| A | CYS52 | |
| E | HIS65 | |
| F | CYS52 | |
| F | HIS65 | |
| A | HIS65 | |
| B | CYS52 | |
| B | HIS65 | |
| C | CYS52 | |
| C | HIS65 | |
| D | CYS52 | |
| D | HIS65 | |
| E | CYS52 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11483494, ECO:0000269|PubMed:12173932 |
| Chain | Residue | Details |
| A | ASN149 | |
| D | ASN149 | |
| D | GLY256 | |
| D | SER349 | |
| E | ASN149 | |
| E | GLY256 | |
| E | SER349 | |
| F | ASN149 | |
| F | GLY256 | |
| F | SER349 | |
| A | GLY256 | |
| A | SER349 | |
| B | ASN149 | |
| B | GLY256 | |
| B | SER349 | |
| C | ASN149 | |
| C | GLY256 | |
| C | SER349 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:11483494, ECO:0000269|PubMed:12173932 |
| Chain | Residue | Details |
| A | LYS119 | |
| B | LYS119 | |
| C | LYS119 | |
| D | LYS119 | |
| E | LYS119 | |
| F | LYS119 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER199 | |
| B | SER199 | |
| C | SER199 | |
| D | SER199 | |
| E | SER199 | |
| F | SER199 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:17087506 |
| Chain | Residue | Details |
| A | LYS211 | |
| F | LYS211 | |
| B | LYS211 | |
| C | LYS211 | |
| D | LYS211 | |
| E | LYS211 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 1 |
| Details | M-CSA 713 |
| Chain | Residue | Details |
| A | LYS119 | covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor, proton relay |
| site_id | MCSA2 |
| Number of Residues | 1 |
| Details | M-CSA 713 |
| Chain | Residue | Details |
| B | LYS119 | covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor, proton relay |
| site_id | MCSA3 |
| Number of Residues | 1 |
| Details | M-CSA 713 |
| Chain | Residue | Details |
| C | LYS119 | covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor, proton relay |
| site_id | MCSA4 |
| Number of Residues | 1 |
| Details | M-CSA 713 |
| Chain | Residue | Details |
| D | LYS119 | covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor, proton relay |
| site_id | MCSA5 |
| Number of Residues | 1 |
| Details | M-CSA 713 |
| Chain | Residue | Details |
| E | LYS119 | covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor, proton relay |
| site_id | MCSA6 |
| Number of Residues | 1 |
| Details | M-CSA 713 |
| Chain | Residue | Details |
| F | LYS119 | covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor, proton relay |
