8SGT

Cryo-EM structure of human NCX1 in Ca2+ bound, activated state (group II in the presence of 0.5 mM Ca2+)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005432	molecular_function	calcium:sodium antiporter activity
A	0006816	biological_process	calcium ion transport
A	0007154	biological_process	cell communication
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH

Chain	Residue	Details
L	TYR193-HIS199

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	74
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	GLU1-LYS39
A	GLY123-THR135
A	SER191-GLU196
A	VAL812-ASP814
A	ASN886-PRO896
A	SER956-SER963

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site_id	SWS_FT_FI2
Number of Residues	200
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	ILE40-ILE60
A	ILE935-GLY955
A	LEU102-CYS122
A	ILE136-PRO156
A	PHE170-ILE190
A	VAL197-ALA217
A	GLY791-SER811
A	THR815-VAL835
A	PHE865-ILE885
A	GLU897-VAL917

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site_id	SWS_FT_FI3
Number of Residues	643
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	ALA61-ASN101
A	ASP157-PHE169
A	ASP218-PHE790
A	THR836-GLN864
A	LEU918-HIS934

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site_id	SWS_FT_FI4
Number of Residues	16
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P23685

Chain	Residue	Details
A	ARG410
A	VAL525
A	THR541
A	ASP577
A	LYS603
A	ALA604
A	LEU605
A	SER708
A	ASP446
A	GLU471
A	ASP472
A	ILE474
A	GLU476
A	HIS479
A	VAL523
A	LYS524

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P70414

Chain	Residue	Details
A	SER275

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P70414, ECO:0000255

Chain	Residue	Details
A	GLN382

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site_id	SWS_FT_FI7
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN9
A	ASN125

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