8S7O

M. tuberculosis gyrase holocomplex with 150 bp DNA and BDM71403

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0003677	molecular_function	DNA binding
A	0003916	molecular_function	DNA topoisomerase activity
A	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0006259	biological_process	DNA metabolic process
A	0006261	biological_process	DNA-templated DNA replication
A	0006265	biological_process	DNA topological change
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0009330	cellular_component	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
A	0016853	molecular_function	isomerase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0034335	molecular_function	DNA negative supercoiling activity
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0003677	molecular_function	DNA binding
B	0003916	molecular_function	DNA topoisomerase activity
B	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005694	cellular_component	chromosome
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0006261	biological_process	DNA-templated DNA replication
B	0006265	biological_process	DNA topological change
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0016853	molecular_function	isomerase activity
B	0034335	molecular_function	DNA negative supercoiling activity
B	0046677	biological_process	response to antibiotic
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0003677	molecular_function	DNA binding
C	0003916	molecular_function	DNA topoisomerase activity
C	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005694	cellular_component	chromosome
C	0005737	cellular_component	cytoplasm
C	0005886	cellular_component	plasma membrane
C	0006259	biological_process	DNA metabolic process
C	0006261	biological_process	DNA-templated DNA replication
C	0006265	biological_process	DNA topological change
C	0009274	cellular_component	peptidoglycan-based cell wall
C	0009330	cellular_component	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
C	0016853	molecular_function	isomerase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0034335	molecular_function	DNA negative supercoiling activity
C	0046677	biological_process	response to antibiotic
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0003677	molecular_function	DNA binding
D	0003916	molecular_function	DNA topoisomerase activity
D	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005694	cellular_component	chromosome
D	0005737	cellular_component	cytoplasm
D	0005886	cellular_component	plasma membrane
D	0006261	biological_process	DNA-templated DNA replication
D	0006265	biological_process	DNA topological change
D	0009274	cellular_component	peptidoglycan-based cell wall
D	0016853	molecular_function	isomerase activity
D	0034335	molecular_function	DNA negative supercoiling activity
D	0046677	biological_process	response to antibiotic
D	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DVSDEDLIAreDV

Chain	Residue	Details
A	ASP504-VAL516

---

site_id	PS00177
Number of Residues	9
Details	TOPOISOMERASE_II DNA topoisomerase II signature. VVEGDSAGG

Chain	Residue	Details
B	VAL457-GLY465

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"O-(5'-phospho-DNA)-tyrosine intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_01897","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Site: {"description":"Interaction with DNA","evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---