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8S7O

M. tuberculosis gyrase holocomplex with 150 bp DNA and BDM71403

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000287molecular_functionmagnesium ion binding
A0003677molecular_functionDNA binding
A0003916molecular_functionDNA topoisomerase activity
A0003918molecular_functionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0006261biological_processDNA-templated DNA replication
A0006265biological_processDNA topological change
A0009274cellular_componentpeptidoglycan-based cell wall
A0009330cellular_componentDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
A0016853molecular_functionisomerase activity
A0016887molecular_functionATP hydrolysis activity
A0034335molecular_functionDNA negative supercoiling activity
A0046677biological_processresponse to antibiotic
A0046872molecular_functionmetal ion binding
B0000166molecular_functionnucleotide binding
B0000287molecular_functionmagnesium ion binding
B0003677molecular_functionDNA binding
B0003916molecular_functionDNA topoisomerase activity
B0003918molecular_functionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0006261biological_processDNA-templated DNA replication
B0006265biological_processDNA topological change
B0009274cellular_componentpeptidoglycan-based cell wall
B0016853molecular_functionisomerase activity
B0034335molecular_functionDNA negative supercoiling activity
B0046677biological_processresponse to antibiotic
B0046872molecular_functionmetal ion binding
C0000166molecular_functionnucleotide binding
C0000287molecular_functionmagnesium ion binding
C0003677molecular_functionDNA binding
C0003916molecular_functionDNA topoisomerase activity
C0003918molecular_functionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005886cellular_componentplasma membrane
C0006261biological_processDNA-templated DNA replication
C0006265biological_processDNA topological change
C0009274cellular_componentpeptidoglycan-based cell wall
C0009330cellular_componentDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
C0016853molecular_functionisomerase activity
C0016887molecular_functionATP hydrolysis activity
C0034335molecular_functionDNA negative supercoiling activity
C0046677biological_processresponse to antibiotic
C0046872molecular_functionmetal ion binding
D0000166molecular_functionnucleotide binding
D0000287molecular_functionmagnesium ion binding
D0003677molecular_functionDNA binding
D0003916molecular_functionDNA topoisomerase activity
D0003918molecular_functionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005886cellular_componentplasma membrane
D0006261biological_processDNA-templated DNA replication
D0006265biological_processDNA topological change
D0009274cellular_componentpeptidoglycan-based cell wall
D0016853molecular_functionisomerase activity
D0034335molecular_functionDNA negative supercoiling activity
D0046677biological_processresponse to antibiotic
D0046872molecular_functionmetal ion binding
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DVSDEDLIAreDV
ChainResidueDetails
AASP504-VAL516

site_idPS00177
Number of Residues9
DetailsTOPOISOMERASE_II DNA topoisomerase II signature. VVEGDSAGG
ChainResidueDetails
BVAL457-GLY465

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues18
DetailsBINDING: BINDING => ECO:0000269|PubMed:24015710
ChainResidueDetails
BTYR12
DTYR12
DASN52
DASP79
DGLY83
DGLY107
DTYR114
DLEU120
DSER169
DGLN370
BASN52
BASP79
BGLY83
BGLY107
BTYR114
BLEU120
BSER169
BGLN370

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01898
ChainResidueDetails
BGLU459
BASP532
BASP534
DGLU459
DASP532
DASP534
CGLU508
CASP515

site_idSWS_FT_FI3
Number of Residues4
DetailsSITE: Interaction with DNA => ECO:0000255|HAMAP-Rule:MF_01898
ChainResidueDetails
BLYS484
BASN487
DLYS484
DASN487

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PDB entries from 2025-06-18

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