8RVO
Proteasomal late precursor complex from pre1-1, state 1
Functional Information from PROSITE/UniProt
| site_id | PS00388 |
| Number of Residues | 23 |
| Details | PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdrhiTiFSPeGRlyQVEYAfkA |
| Chain | Residue | Details |
| A | TYR6-ALA28 | |
| D | TYR4-ALA26 | |
| T | TYR6-ALA28 | |
| S | TYR8-ALA30 | |
| U | TYR8-ALA30 | |
| B | TYR5-ALA27 | |
| C | TYR6-SER28 |
| site_id | PS00854 |
| Number of Residues | 48 |
| Details | PROTEASOME_BETA_1 Proteasome beta-type subunits signature. MAVtFkdGVILGADsrtttgayianrvtd.KltrvhdkiwccrsGsaAD |
| Chain | Residue | Details |
| V | MET4-ASP51 | |
| D | VAL34-ASP81 | |
| X | VAL13-ASP59 | |
| Y | LEU5-ASP52 | |
| 1 | LEU13-ASP60 | |
| W | VAL4-ASP51 | |
| C | ILE36-ASP83 | |
| 2 | ILE12-ASP59 | |
| Z | LEU79-ASP126 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:9087403 |
| Chain | Residue | Details |
| L | THR1 | |
| Z | THR76 | |
| C | LYS199 | |
| C | LYS227 | |
| Q | LYS100 | |
| Q | LYS199 | |
| Q | LYS231 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| L | ALA49 | |
| Z | ALA124 | |
| X | LYS70 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198 |
| Chain | Residue | Details |
| E | SER251 | |
| S | SER251 | |
| O | LYS232 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 8 |
| Details | M-CSA 177 |
| Chain | Residue | Details |
| I | THR1 | covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor |
| I | ASP17 | activator, steric locator |
| I | ARG19 | activator |
| I | LYS33 | activator, electrostatic stabiliser |
| I | GLY47 | electrostatic stabiliser |
| I | SER129 | activator, electrostatic stabiliser |
| I | ASP166 | activator, steric locator |
| I | SER169 | activator, electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 8 |
| Details | M-CSA 177 |
| Chain | Residue | Details |
| W | THR1 | covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor |
| W | ASP17 | activator, steric locator |
| W | ARG19 | activator |
| W | LYS33 | activator, electrostatic stabiliser |
| W | GLY47 | electrostatic stabiliser |
| W | SER129 | activator, electrostatic stabiliser |
| W | ASP166 | activator, steric locator |
| W | SER169 | activator, electrostatic stabiliser |
