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8RU2

Structure of the F-actin barbed end bound by formin mDia1

Functional Information from GO Data
ChainGOidnamespacecontents
B0000166molecular_functionnucleotide binding
B0000776cellular_componentkinetochore
B0000785cellular_componentchromatin
B0000786cellular_componentnucleosome
B0001738biological_processmorphogenesis of a polarized epithelium
B0005200molecular_functionstructural constituent of cytoskeleton
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005884cellular_componentactin filament
B0005886cellular_componentplasma membrane
B0005903cellular_componentbrush border
B0005911cellular_componentcell-cell junction
B0005912cellular_componentadherens junction
B0005925cellular_componentfocal adhesion
B0006338biological_processchromatin remodeling
B0006357biological_processregulation of transcription by RNA polymerase II
B0007010biological_processcytoskeleton organization
B0007163biological_processestablishment or maintenance of cell polarity
B0007409biological_processaxonogenesis
B0008284biological_processpositive regulation of cell population proliferation
B0015629cellular_componentactin cytoskeleton
B0016020cellular_componentmembrane
B0016363cellular_componentnuclear matrix
B0016514cellular_componentSWI/SNF complex
B0016586cellular_componentRSC-type complex
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0019894molecular_functionkinesin binding
B0019901molecular_functionprotein kinase binding
B0021762biological_processsubstantia nigra development
B0030027cellular_componentlamellipodium
B0030071biological_processregulation of mitotic metaphase/anaphase transition
B0030235molecular_functionnitric-oxide synthase regulator activity
B0030424cellular_componentaxon
B0030863cellular_componentcortical cytoskeleton
B0030957molecular_functionTat protein binding
B0031492molecular_functionnucleosomal DNA binding
B0031982cellular_componentvesicle
B0032991cellular_componentprotein-containing complex
B0034333biological_processadherens junction assembly
B0035060cellular_componentbrahma complex
B0035267cellular_componentNuA4 histone acetyltransferase complex
B0035633biological_processmaintenance of blood-brain barrier
B0036464cellular_componentcytoplasmic ribonucleoprotein granule
B0042802molecular_functionidentical protein binding
B0042981biological_processregulation of apoptotic process
B0043296cellular_componentapical junction complex
B0044305cellular_componentcalyx of Held
B0045176biological_processapical protein localization
B0045202cellular_componentsynapse
B0045582biological_processpositive regulation of T cell differentiation
B0045596biological_processnegative regulation of cell differentiation
B0045597biological_processpositive regulation of cell differentiation
B0045663biological_processpositive regulation of myoblast differentiation
B0045893biological_processpositive regulation of DNA-templated transcription
B0048156molecular_functiontau protein binding
B0048870biological_processcell motility
B0050998molecular_functionnitric-oxide synthase binding
B0051621biological_processregulation of norepinephrine uptake
B0051623biological_processpositive regulation of norepinephrine uptake
B0051726biological_processregulation of cell cycle
B0070062cellular_componentextracellular exosome
B0070160cellular_componenttight junction
B0070316biological_processregulation of G0 to G1 transition
B0070527biological_processplatelet aggregation
B0071564cellular_componentnpBAF complex
B0071565cellular_componentnBAF complex
B0071896biological_processprotein localization to adherens junction
B0072562cellular_componentblood microparticle
B0072749biological_processcellular response to cytochalasin B
B0097433cellular_componentdense body
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098793cellular_componentpresynapse
B0098871cellular_componentpostsynaptic actin cytoskeleton
B0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
B0098974biological_processpostsynaptic actin cytoskeleton organization
B0098978cellular_componentglutamatergic synapse
B0140092cellular_componentbBAF complex
B0140288cellular_componentGBAF complex
B0141108molecular_functiontransporter regulator activity
B0150111biological_processregulation of transepithelial transport
B1900242biological_processregulation of synaptic vesicle endocytosis
B1902459biological_processpositive regulation of stem cell population maintenance
B1903076biological_processregulation of protein localization to plasma membrane
B1905168biological_processpositive regulation of double-strand break repair via homologous recombination
B1990904cellular_componentribonucleoprotein complex
B2000045biological_processregulation of G1/S transition of mitotic cell cycle
B2000779biological_processregulation of double-strand break repair
B2000781biological_processpositive regulation of double-strand break repair
B2000819biological_processregulation of nucleotide-excision repair
C0000166molecular_functionnucleotide binding
C0000776cellular_componentkinetochore
C0000785cellular_componentchromatin
C0000786cellular_componentnucleosome
C0001738biological_processmorphogenesis of a polarized epithelium
C0005200molecular_functionstructural constituent of cytoskeleton
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005884cellular_componentactin filament
C0005886cellular_componentplasma membrane
C0005903cellular_componentbrush border
C0005911cellular_componentcell-cell junction
C0005912cellular_componentadherens junction
C0005925cellular_componentfocal adhesion
C0006338biological_processchromatin remodeling
C0006357biological_processregulation of transcription by RNA polymerase II
C0007010biological_processcytoskeleton organization
C0007163biological_processestablishment or maintenance of cell polarity
C0007409biological_processaxonogenesis
C0008284biological_processpositive regulation of cell population proliferation
C0015629cellular_componentactin cytoskeleton
C0016020cellular_componentmembrane
C0016363cellular_componentnuclear matrix
C0016514cellular_componentSWI/SNF complex
C0016586cellular_componentRSC-type complex
C0016787molecular_functionhydrolase activity
C0016887molecular_functionATP hydrolysis activity
C0019894molecular_functionkinesin binding
C0019901molecular_functionprotein kinase binding
C0021762biological_processsubstantia nigra development
C0030027cellular_componentlamellipodium
C0030071biological_processregulation of mitotic metaphase/anaphase transition
C0030235molecular_functionnitric-oxide synthase regulator activity
C0030424cellular_componentaxon
C0030863cellular_componentcortical cytoskeleton
C0030957molecular_functionTat protein binding
C0031492molecular_functionnucleosomal DNA binding
C0031982cellular_componentvesicle
C0032991cellular_componentprotein-containing complex
C0034333biological_processadherens junction assembly
C0035060cellular_componentbrahma complex
C0035267cellular_componentNuA4 histone acetyltransferase complex
C0035633biological_processmaintenance of blood-brain barrier
C0036464cellular_componentcytoplasmic ribonucleoprotein granule
C0042802molecular_functionidentical protein binding
C0042981biological_processregulation of apoptotic process
C0043296cellular_componentapical junction complex
C0044305cellular_componentcalyx of Held
C0045176biological_processapical protein localization
C0045202cellular_componentsynapse
C0045582biological_processpositive regulation of T cell differentiation
C0045596biological_processnegative regulation of cell differentiation
C0045597biological_processpositive regulation of cell differentiation
C0045663biological_processpositive regulation of myoblast differentiation
C0045893biological_processpositive regulation of DNA-templated transcription
C0048156molecular_functiontau protein binding
C0048870biological_processcell motility
C0050998molecular_functionnitric-oxide synthase binding
C0051621biological_processregulation of norepinephrine uptake
C0051623biological_processpositive regulation of norepinephrine uptake
C0051726biological_processregulation of cell cycle
C0070062cellular_componentextracellular exosome
C0070160cellular_componenttight junction
C0070316biological_processregulation of G0 to G1 transition
C0070527biological_processplatelet aggregation
C0071564cellular_componentnpBAF complex
C0071565cellular_componentnBAF complex
C0071896biological_processprotein localization to adherens junction
C0072562cellular_componentblood microparticle
C0072749biological_processcellular response to cytochalasin B
C0097433cellular_componentdense body
C0098685cellular_componentSchaffer collateral - CA1 synapse
C0098793cellular_componentpresynapse
C0098871cellular_componentpostsynaptic actin cytoskeleton
C0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
C0098974biological_processpostsynaptic actin cytoskeleton organization
C0098978cellular_componentglutamatergic synapse
C0140092cellular_componentbBAF complex
C0140288cellular_componentGBAF complex
C0141108molecular_functiontransporter regulator activity
C0150111biological_processregulation of transepithelial transport
C1900242biological_processregulation of synaptic vesicle endocytosis
C1902459biological_processpositive regulation of stem cell population maintenance
C1903076biological_processregulation of protein localization to plasma membrane
C1905168biological_processpositive regulation of double-strand break repair via homologous recombination
C1990904cellular_componentribonucleoprotein complex
C2000045biological_processregulation of G1/S transition of mitotic cell cycle
C2000779biological_processregulation of double-strand break repair
C2000781biological_processpositive regulation of double-strand break repair
C2000819biological_processregulation of nucleotide-excision repair
D0000166molecular_functionnucleotide binding
D0000776cellular_componentkinetochore
D0000785cellular_componentchromatin
D0000786cellular_componentnucleosome
D0001738biological_processmorphogenesis of a polarized epithelium
D0005200molecular_functionstructural constituent of cytoskeleton
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005884cellular_componentactin filament
D0005886cellular_componentplasma membrane
D0005903cellular_componentbrush border
D0005911cellular_componentcell-cell junction
D0005912cellular_componentadherens junction
D0005925cellular_componentfocal adhesion
D0006338biological_processchromatin remodeling
D0006357biological_processregulation of transcription by RNA polymerase II
D0007010biological_processcytoskeleton organization
D0007163biological_processestablishment or maintenance of cell polarity
D0007409biological_processaxonogenesis
D0008284biological_processpositive regulation of cell population proliferation
D0015629cellular_componentactin cytoskeleton
D0016020cellular_componentmembrane
D0016363cellular_componentnuclear matrix
D0016514cellular_componentSWI/SNF complex
D0016586cellular_componentRSC-type complex
D0016787molecular_functionhydrolase activity
D0016887molecular_functionATP hydrolysis activity
D0019894molecular_functionkinesin binding
D0019901molecular_functionprotein kinase binding
D0021762biological_processsubstantia nigra development
D0030027cellular_componentlamellipodium
D0030071biological_processregulation of mitotic metaphase/anaphase transition
D0030235molecular_functionnitric-oxide synthase regulator activity
D0030424cellular_componentaxon
D0030863cellular_componentcortical cytoskeleton
D0030957molecular_functionTat protein binding
D0031492molecular_functionnucleosomal DNA binding
D0031982cellular_componentvesicle
D0032991cellular_componentprotein-containing complex
D0034333biological_processadherens junction assembly
D0035060cellular_componentbrahma complex
D0035267cellular_componentNuA4 histone acetyltransferase complex
D0035633biological_processmaintenance of blood-brain barrier
D0036464cellular_componentcytoplasmic ribonucleoprotein granule
D0042802molecular_functionidentical protein binding
D0042981biological_processregulation of apoptotic process
D0043296cellular_componentapical junction complex
D0044305cellular_componentcalyx of Held
D0045176biological_processapical protein localization
D0045202cellular_componentsynapse
D0045582biological_processpositive regulation of T cell differentiation
D0045596biological_processnegative regulation of cell differentiation
D0045597biological_processpositive regulation of cell differentiation
D0045663biological_processpositive regulation of myoblast differentiation
D0045893biological_processpositive regulation of DNA-templated transcription
D0048156molecular_functiontau protein binding
D0048870biological_processcell motility
D0050998molecular_functionnitric-oxide synthase binding
D0051621biological_processregulation of norepinephrine uptake
D0051623biological_processpositive regulation of norepinephrine uptake
D0051726biological_processregulation of cell cycle
D0070062cellular_componentextracellular exosome
D0070160cellular_componenttight junction
D0070316biological_processregulation of G0 to G1 transition
D0070527biological_processplatelet aggregation
D0071564cellular_componentnpBAF complex
D0071565cellular_componentnBAF complex
D0071896biological_processprotein localization to adherens junction
D0072562cellular_componentblood microparticle
D0072749biological_processcellular response to cytochalasin B
D0097433cellular_componentdense body
D0098685cellular_componentSchaffer collateral - CA1 synapse
D0098793cellular_componentpresynapse
D0098871cellular_componentpostsynaptic actin cytoskeleton
D0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
D0098974biological_processpostsynaptic actin cytoskeleton organization
D0098978cellular_componentglutamatergic synapse
D0140092cellular_componentbBAF complex
D0140288cellular_componentGBAF complex
D0141108molecular_functiontransporter regulator activity
D0150111biological_processregulation of transepithelial transport
D1900242biological_processregulation of synaptic vesicle endocytosis
D1902459biological_processpositive regulation of stem cell population maintenance
D1903076biological_processregulation of protein localization to plasma membrane
D1905168biological_processpositive regulation of double-strand break repair via homologous recombination
D1990904cellular_componentribonucleoprotein complex
D2000045biological_processregulation of G1/S transition of mitotic cell cycle
D2000779biological_processregulation of double-strand break repair
D2000781biological_processpositive regulation of double-strand break repair
D2000819biological_processregulation of nucleotide-excision repair
E0003824molecular_functioncatalytic activity
E0003908molecular_functionmethylated-DNA-[protein]-cysteine S-methyltransferase activity
E0006281biological_processDNA repair
F0003824molecular_functioncatalytic activity
F0003908molecular_functionmethylated-DNA-[protein]-cysteine S-methyltransferase activity
F0006281biological_processDNA repair
Functional Information from PROSITE/UniProt
site_idPS00374
Number of Residues7
DetailsMGMT Methylated-DNA--protein-cysteine methyltransferase active site. IPCHRVV
ChainResidueDetails
EILE635-VAL641

site_idPS00406
Number of Residues11
DetailsACTINS_1 Actins signature 1. YVGDEAQs.KRG
ChainResidueDetails
BTYR53-GLY63

site_idPS00432
Number of Residues9
DetailsACTINS_2 Actins signature 2. WISKqEYDE
ChainResidueDetails
BTRP356-GLU364

site_idPS00639
Number of Residues11
DetailsTHIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. GLHEIKLLGKG
ChainResidueDetails
EGLY519-GLY529

site_idPS01132
Number of Residues13
DetailsACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR
ChainResidueDetails
BLEU104-ARG116

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Nucleophile; methyl group acceptor
ChainResidueDetails
ECYS637
FCYS637
DASP2

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING:
ChainResidueDetails
ECYS497
ECYS516
EHIS521
EHIS577
FCYS497
FCYS516
FHIS521
FHIS577

site_idSWS_FT_FI3
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:10747039, ECO:0000269|PubMed:15964013
ChainResidueDetails
ETHR587
FASN615
FALA620
FSER643
ETYR606
EGLN607
EASN615
EALA620
ESER643
FTHR587
FTYR606
FGLN607

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ESER506
FSER506
DLYS84

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:O60610
ChainResidueDetails
ETHR751
FTHR751
DLYS50

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:O60610
ChainResidueDetails
ELYS1040
ELYS1086
FLYS1040
FLYS1086
DGLU270

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:17947660
ChainResidueDetails
ETYR1104
FTYR1104

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O60610
ChainResidueDetails
ESER1237
FSER1237

237423

PDB entries from 2025-06-11

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