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8RTY

Structure of the F-actin barbed end bound by Cdc12 and profilin (ring complex) at a resolution of 6.3 Angstrom

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0000079biological_processregulation of cyclin-dependent protein serine/threonine kinase activity
A0000776cellular_componentkinetochore
A0000785cellular_componentchromatin
A0000786cellular_componentnucleosome
A0001738biological_processmorphogenesis of a polarized epithelium
A0005200molecular_functionstructural constituent of cytoskeleton
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005884cellular_componentactin filament
A0005886cellular_componentplasma membrane
A0005903cellular_componentbrush border
A0005911cellular_componentcell-cell junction
A0005912cellular_componentadherens junction
A0005925cellular_componentfocal adhesion
A0006338biological_processchromatin remodeling
A0006357biological_processregulation of transcription by RNA polymerase II
A0007163biological_processestablishment or maintenance of cell polarity
A0007409biological_processaxonogenesis
A0008284biological_processpositive regulation of cell population proliferation
A0015629cellular_componentactin cytoskeleton
A0016020cellular_componentmembrane
A0016363cellular_componentnuclear matrix
A0016514cellular_componentSWI/SNF complex
A0016586cellular_componentRSC-type complex
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0019894molecular_functionkinesin binding
A0019901molecular_functionprotein kinase binding
A0021762biological_processsubstantia nigra development
A0022898biological_processregulation of transmembrane transporter activity
A0030027cellular_componentlamellipodium
A0030071biological_processregulation of mitotic metaphase/anaphase transition
A0030424cellular_componentaxon
A0030863cellular_componentcortical cytoskeleton
A0030957molecular_functionTat protein binding
A0031492molecular_functionnucleosomal DNA binding
A0031982cellular_componentvesicle
A0032091biological_processnegative regulation of protein binding
A0032991cellular_componentprotein-containing complex
A0034333biological_processadherens junction assembly
A0035060cellular_componentbrahma complex
A0035267cellular_componentNuA4 histone acetyltransferase complex
A0035633biological_processmaintenance of blood-brain barrier
A0036464cellular_componentcytoplasmic ribonucleoprotein granule
A0042802molecular_functionidentical protein binding
A0042981biological_processregulation of apoptotic process
A0043296cellular_componentapical junction complex
A0044305cellular_componentcalyx of Held
A0045176biological_processapical protein localization
A0045202cellular_componentsynapse
A0045582biological_processpositive regulation of T cell differentiation
A0045596biological_processnegative regulation of cell differentiation
A0045597biological_processpositive regulation of cell differentiation
A0045663biological_processpositive regulation of myoblast differentiation
A0045893biological_processpositive regulation of DNA-templated transcription
A0048156molecular_functiontau protein binding
A0048870biological_processcell motility
A0050998molecular_functionnitric-oxide synthase binding
A0051621biological_processregulation of norepinephrine uptake
A0051623biological_processpositive regulation of norepinephrine uptake
A0051726biological_processregulation of cell cycle
A0070062cellular_componentextracellular exosome
A0070160cellular_componenttight junction
A0070316biological_processregulation of G0 to G1 transition
A0070527biological_processplatelet aggregation
A0071564cellular_componentnpBAF complex
A0071565cellular_componentnBAF complex
A0071896biological_processprotein localization to adherens junction
A0072562cellular_componentblood microparticle
A0072749biological_processcellular response to cytochalasin B
A0097433cellular_componentdense body
A0098685cellular_componentSchaffer collateral - CA1 synapse
A0098793cellular_componentpresynapse
A0098871cellular_componentpostsynaptic actin cytoskeleton
A0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
A0098974biological_processpostsynaptic actin cytoskeleton organization
A0098978cellular_componentglutamatergic synapse
A0140092cellular_componentbBAF complex
A0140288cellular_componentGBAF complex
A0150111biological_processregulation of transepithelial transport
A1900242biological_processregulation of synaptic vesicle endocytosis
A1902459biological_processpositive regulation of stem cell population maintenance
A1903076biological_processregulation of protein localization to plasma membrane
A1905168biological_processpositive regulation of double-strand break repair via homologous recombination
A1990904cellular_componentribonucleoprotein complex
A2000045biological_processregulation of G1/S transition of mitotic cell cycle
A2000779biological_processregulation of double-strand break repair
A2000781biological_processpositive regulation of double-strand break repair
A2000819biological_processregulation of nucleotide-excision repair
B0000079biological_processregulation of cyclin-dependent protein serine/threonine kinase activity
B0000776cellular_componentkinetochore
B0000785cellular_componentchromatin
B0000786cellular_componentnucleosome
B0001738biological_processmorphogenesis of a polarized epithelium
B0005200molecular_functionstructural constituent of cytoskeleton
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005884cellular_componentactin filament
B0005886cellular_componentplasma membrane
B0005903cellular_componentbrush border
B0005911cellular_componentcell-cell junction
B0005912cellular_componentadherens junction
B0005925cellular_componentfocal adhesion
B0006338biological_processchromatin remodeling
B0006357biological_processregulation of transcription by RNA polymerase II
B0007163biological_processestablishment or maintenance of cell polarity
B0007409biological_processaxonogenesis
B0008284biological_processpositive regulation of cell population proliferation
B0015629cellular_componentactin cytoskeleton
B0016020cellular_componentmembrane
B0016363cellular_componentnuclear matrix
B0016514cellular_componentSWI/SNF complex
B0016586cellular_componentRSC-type complex
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0019894molecular_functionkinesin binding
B0019901molecular_functionprotein kinase binding
B0021762biological_processsubstantia nigra development
B0022898biological_processregulation of transmembrane transporter activity
B0030027cellular_componentlamellipodium
B0030071biological_processregulation of mitotic metaphase/anaphase transition
B0030424cellular_componentaxon
B0030863cellular_componentcortical cytoskeleton
B0030957molecular_functionTat protein binding
B0031492molecular_functionnucleosomal DNA binding
B0031982cellular_componentvesicle
B0032091biological_processnegative regulation of protein binding
B0032991cellular_componentprotein-containing complex
B0034333biological_processadherens junction assembly
B0035060cellular_componentbrahma complex
B0035267cellular_componentNuA4 histone acetyltransferase complex
B0035633biological_processmaintenance of blood-brain barrier
B0036464cellular_componentcytoplasmic ribonucleoprotein granule
B0042802molecular_functionidentical protein binding
B0042981biological_processregulation of apoptotic process
B0043296cellular_componentapical junction complex
B0044305cellular_componentcalyx of Held
B0045176biological_processapical protein localization
B0045202cellular_componentsynapse
B0045582biological_processpositive regulation of T cell differentiation
B0045596biological_processnegative regulation of cell differentiation
B0045597biological_processpositive regulation of cell differentiation
B0045663biological_processpositive regulation of myoblast differentiation
B0045893biological_processpositive regulation of DNA-templated transcription
B0048156molecular_functiontau protein binding
B0048870biological_processcell motility
B0050998molecular_functionnitric-oxide synthase binding
B0051621biological_processregulation of norepinephrine uptake
B0051623biological_processpositive regulation of norepinephrine uptake
B0051726biological_processregulation of cell cycle
B0070062cellular_componentextracellular exosome
B0070160cellular_componenttight junction
B0070316biological_processregulation of G0 to G1 transition
B0070527biological_processplatelet aggregation
B0071564cellular_componentnpBAF complex
B0071565cellular_componentnBAF complex
B0071896biological_processprotein localization to adherens junction
B0072562cellular_componentblood microparticle
B0072749biological_processcellular response to cytochalasin B
B0097433cellular_componentdense body
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098793cellular_componentpresynapse
B0098871cellular_componentpostsynaptic actin cytoskeleton
B0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
B0098974biological_processpostsynaptic actin cytoskeleton organization
B0098978cellular_componentglutamatergic synapse
B0140092cellular_componentbBAF complex
B0140288cellular_componentGBAF complex
B0150111biological_processregulation of transepithelial transport
B1900242biological_processregulation of synaptic vesicle endocytosis
B1902459biological_processpositive regulation of stem cell population maintenance
B1903076biological_processregulation of protein localization to plasma membrane
B1905168biological_processpositive regulation of double-strand break repair via homologous recombination
B1990904cellular_componentribonucleoprotein complex
B2000045biological_processregulation of G1/S transition of mitotic cell cycle
B2000779biological_processregulation of double-strand break repair
B2000781biological_processpositive regulation of double-strand break repair
B2000819biological_processregulation of nucleotide-excision repair
C0000079biological_processregulation of cyclin-dependent protein serine/threonine kinase activity
C0000776cellular_componentkinetochore
C0000785cellular_componentchromatin
C0000786cellular_componentnucleosome
C0001738biological_processmorphogenesis of a polarized epithelium
C0005200molecular_functionstructural constituent of cytoskeleton
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005884cellular_componentactin filament
C0005886cellular_componentplasma membrane
C0005903cellular_componentbrush border
C0005911cellular_componentcell-cell junction
C0005912cellular_componentadherens junction
C0005925cellular_componentfocal adhesion
C0006338biological_processchromatin remodeling
C0006357biological_processregulation of transcription by RNA polymerase II
C0007163biological_processestablishment or maintenance of cell polarity
C0007409biological_processaxonogenesis
C0008284biological_processpositive regulation of cell population proliferation
C0015629cellular_componentactin cytoskeleton
C0016020cellular_componentmembrane
C0016363cellular_componentnuclear matrix
C0016514cellular_componentSWI/SNF complex
C0016586cellular_componentRSC-type complex
C0016787molecular_functionhydrolase activity
C0016887molecular_functionATP hydrolysis activity
C0019894molecular_functionkinesin binding
C0019901molecular_functionprotein kinase binding
C0021762biological_processsubstantia nigra development
C0022898biological_processregulation of transmembrane transporter activity
C0030027cellular_componentlamellipodium
C0030071biological_processregulation of mitotic metaphase/anaphase transition
C0030424cellular_componentaxon
C0030863cellular_componentcortical cytoskeleton
C0030957molecular_functionTat protein binding
C0031492molecular_functionnucleosomal DNA binding
C0031982cellular_componentvesicle
C0032091biological_processnegative regulation of protein binding
C0032991cellular_componentprotein-containing complex
C0034333biological_processadherens junction assembly
C0035060cellular_componentbrahma complex
C0035267cellular_componentNuA4 histone acetyltransferase complex
C0035633biological_processmaintenance of blood-brain barrier
C0036464cellular_componentcytoplasmic ribonucleoprotein granule
C0042802molecular_functionidentical protein binding
C0042981biological_processregulation of apoptotic process
C0043296cellular_componentapical junction complex
C0044305cellular_componentcalyx of Held
C0045176biological_processapical protein localization
C0045202cellular_componentsynapse
C0045582biological_processpositive regulation of T cell differentiation
C0045596biological_processnegative regulation of cell differentiation
C0045597biological_processpositive regulation of cell differentiation
C0045663biological_processpositive regulation of myoblast differentiation
C0045893biological_processpositive regulation of DNA-templated transcription
C0048156molecular_functiontau protein binding
C0048870biological_processcell motility
C0050998molecular_functionnitric-oxide synthase binding
C0051621biological_processregulation of norepinephrine uptake
C0051623biological_processpositive regulation of norepinephrine uptake
C0051726biological_processregulation of cell cycle
C0070062cellular_componentextracellular exosome
C0070160cellular_componenttight junction
C0070316biological_processregulation of G0 to G1 transition
C0070527biological_processplatelet aggregation
C0071564cellular_componentnpBAF complex
C0071565cellular_componentnBAF complex
C0071896biological_processprotein localization to adherens junction
C0072562cellular_componentblood microparticle
C0072749biological_processcellular response to cytochalasin B
C0097433cellular_componentdense body
C0098685cellular_componentSchaffer collateral - CA1 synapse
C0098793cellular_componentpresynapse
C0098871cellular_componentpostsynaptic actin cytoskeleton
C0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
C0098974biological_processpostsynaptic actin cytoskeleton organization
C0098978cellular_componentglutamatergic synapse
C0140092cellular_componentbBAF complex
C0140288cellular_componentGBAF complex
C0150111biological_processregulation of transepithelial transport
C1900242biological_processregulation of synaptic vesicle endocytosis
C1902459biological_processpositive regulation of stem cell population maintenance
C1903076biological_processregulation of protein localization to plasma membrane
C1905168biological_processpositive regulation of double-strand break repair via homologous recombination
C1990904cellular_componentribonucleoprotein complex
C2000045biological_processregulation of G1/S transition of mitotic cell cycle
C2000779biological_processregulation of double-strand break repair
C2000781biological_processpositive regulation of double-strand break repair
C2000819biological_processregulation of nucleotide-excision repair
D0000079biological_processregulation of cyclin-dependent protein serine/threonine kinase activity
D0000776cellular_componentkinetochore
D0000785cellular_componentchromatin
D0000786cellular_componentnucleosome
D0001738biological_processmorphogenesis of a polarized epithelium
D0005200molecular_functionstructural constituent of cytoskeleton
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005884cellular_componentactin filament
D0005886cellular_componentplasma membrane
D0005903cellular_componentbrush border
D0005911cellular_componentcell-cell junction
D0005912cellular_componentadherens junction
D0005925cellular_componentfocal adhesion
D0006338biological_processchromatin remodeling
D0006357biological_processregulation of transcription by RNA polymerase II
D0007163biological_processestablishment or maintenance of cell polarity
D0007409biological_processaxonogenesis
D0008284biological_processpositive regulation of cell population proliferation
D0015629cellular_componentactin cytoskeleton
D0016020cellular_componentmembrane
D0016363cellular_componentnuclear matrix
D0016514cellular_componentSWI/SNF complex
D0016586cellular_componentRSC-type complex
D0016787molecular_functionhydrolase activity
D0016887molecular_functionATP hydrolysis activity
D0019894molecular_functionkinesin binding
D0019901molecular_functionprotein kinase binding
D0021762biological_processsubstantia nigra development
D0022898biological_processregulation of transmembrane transporter activity
D0030027cellular_componentlamellipodium
D0030071biological_processregulation of mitotic metaphase/anaphase transition
D0030424cellular_componentaxon
D0030863cellular_componentcortical cytoskeleton
D0030957molecular_functionTat protein binding
D0031492molecular_functionnucleosomal DNA binding
D0031982cellular_componentvesicle
D0032091biological_processnegative regulation of protein binding
D0032991cellular_componentprotein-containing complex
D0034333biological_processadherens junction assembly
D0035060cellular_componentbrahma complex
D0035267cellular_componentNuA4 histone acetyltransferase complex
D0035633biological_processmaintenance of blood-brain barrier
D0036464cellular_componentcytoplasmic ribonucleoprotein granule
D0042802molecular_functionidentical protein binding
D0042981biological_processregulation of apoptotic process
D0043296cellular_componentapical junction complex
D0044305cellular_componentcalyx of Held
D0045176biological_processapical protein localization
D0045202cellular_componentsynapse
D0045582biological_processpositive regulation of T cell differentiation
D0045596biological_processnegative regulation of cell differentiation
D0045597biological_processpositive regulation of cell differentiation
D0045663biological_processpositive regulation of myoblast differentiation
D0045893biological_processpositive regulation of DNA-templated transcription
D0048156molecular_functiontau protein binding
D0048870biological_processcell motility
D0050998molecular_functionnitric-oxide synthase binding
D0051621biological_processregulation of norepinephrine uptake
D0051623biological_processpositive regulation of norepinephrine uptake
D0051726biological_processregulation of cell cycle
D0070062cellular_componentextracellular exosome
D0070160cellular_componenttight junction
D0070316biological_processregulation of G0 to G1 transition
D0070527biological_processplatelet aggregation
D0071564cellular_componentnpBAF complex
D0071565cellular_componentnBAF complex
D0071896biological_processprotein localization to adherens junction
D0072562cellular_componentblood microparticle
D0072749biological_processcellular response to cytochalasin B
D0097433cellular_componentdense body
D0098685cellular_componentSchaffer collateral - CA1 synapse
D0098793cellular_componentpresynapse
D0098871cellular_componentpostsynaptic actin cytoskeleton
D0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
D0098974biological_processpostsynaptic actin cytoskeleton organization
D0098978cellular_componentglutamatergic synapse
D0140092cellular_componentbBAF complex
D0140288cellular_componentGBAF complex
D0150111biological_processregulation of transepithelial transport
D1900242biological_processregulation of synaptic vesicle endocytosis
D1902459biological_processpositive regulation of stem cell population maintenance
D1903076biological_processregulation of protein localization to plasma membrane
D1905168biological_processpositive regulation of double-strand break repair via homologous recombination
D1990904cellular_componentribonucleoprotein complex
D2000045biological_processregulation of G1/S transition of mitotic cell cycle
D2000779biological_processregulation of double-strand break repair
D2000781biological_processpositive regulation of double-strand break repair
D2000819biological_processregulation of nucleotide-excision repair
P0000774molecular_functionadenyl-nucleotide exchange factor activity
P0001784molecular_functionphosphotyrosine residue binding
P0001843biological_processneural tube closure
P0003723molecular_functionRNA binding
P0003779molecular_functionactin binding
P0003785molecular_functionactin monomer binding
P0005515molecular_functionprotein binding
P0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
P0005634cellular_componentnucleus
P0005737cellular_componentcytoplasm
P0005829cellular_componentcytosol
P0005856cellular_componentcytoskeleton
P0005925cellular_componentfocal adhesion
P0005938cellular_componentcell cortex
P0006357biological_processregulation of transcription by RNA polymerase II
P0010634biological_processpositive regulation of epithelial cell migration
P0016020cellular_componentmembrane
P0030833biological_processregulation of actin filament polymerization
P0030837biological_processnegative regulation of actin filament polymerization
P0030838biological_processpositive regulation of actin filament polymerization
P0031267molecular_functionsmall GTPase binding
P0032232biological_processnegative regulation of actin filament bundle assembly
P0032233biological_processpositive regulation of actin filament bundle assembly
P0032781biological_processpositive regulation of ATP-dependent activity
P0044087biological_processregulation of cellular component biogenesis
P0045296molecular_functioncadherin binding
P0050804biological_processmodulation of chemical synaptic transmission
P0050821biological_processprotein stabilization
P0051497biological_processnegative regulation of stress fiber assembly
P0060074biological_processsynapse maturation
P0070062cellular_componentextracellular exosome
P0070064molecular_functionproline-rich region binding
P0072562cellular_componentblood microparticle
P0098885biological_processmodification of postsynaptic actin cytoskeleton
P0098978cellular_componentglutamatergic synapse
P0110053biological_processregulation of actin filament organization
P1900029biological_processpositive regulation of ruffle assembly
Functional Information from PROSITE/UniProt
site_idPS00374
Number of Residues7
DetailsMGMT Methylated-DNA--protein-cysteine methyltransferase active site. IPCHRVV
ChainResidueDetails
EILE833-VAL839

site_idPS00406
Number of Residues11
DetailsACTINS_1 Actins signature 1. YVGDEAQs.KRG
ChainResidueDetails
ATYR53-GLY63

site_idPS00414
Number of Residues8
DetailsPROFILIN Profilin signature. .AgWNaYiD
ChainResidueDetails
PALA1-ASP8

site_idPS00432
Number of Residues9
DetailsACTINS_2 Actins signature 2. WISKqEYDE
ChainResidueDetails
ATRP356-GLU364

site_idPS00639
Number of Residues11
DetailsTHIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. GLHEIKLLGKG
ChainResidueDetails
EGLY717-GLY727

site_idPS01132
Number of Residues13
DetailsACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR
ChainResidueDetails
ALEU104-ARG116

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0000269|PubMed:3342873, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:25944712
ChainResidueDetails
PALA1
FCYS835
CASP2
DASP2

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P62963
ChainResidueDetails
PSER27
ECYS714
EHIS719
EHIS775
FCYS695
FCYS714
FHIS719
FHIS775

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
PSER56
FASN813
FALA818
FSER841
ETYR804
EGLN805
EASN813
EALA818
ESER841
FTHR785
FTYR804
FGLN805

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332
ChainResidueDetails
PSER84
FSER704
CLYS84
DLYS84

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
PLYS104
PLYS107
CLYS50
DLYS50

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455
ChainResidueDetails
PTYR128
AGLU270
BGLU270
CGLU270
DGLU270

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine; by ROCK1 => ECO:0000269|PubMed:18573880
ChainResidueDetails
PSER137

site_idSWS_FT_FI8
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
ChainResidueDetails
PLYS53

Catalytic Information from CSA
site_idMCSA1
Number of Residues5
DetailsM-CSA 251
ChainResidueDetails
ETYR804hydrogen bond donor, proton donor
EASN827electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
ECYS835hydrogen bond donor, nucleophile, proton donor
EHIS836hydrogen bond acceptor, hydrogen bond donor, proton acceptor
EGLU862hydrogen bond acceptor, increase basicity

site_idMCSA2
Number of Residues5
DetailsM-CSA 251
ChainResidueDetails
FTYR804hydrogen bond donor, proton donor
FASN827electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
FCYS835hydrogen bond donor, nucleophile, proton donor
FHIS836hydrogen bond acceptor, hydrogen bond donor, proton acceptor
FGLU862hydrogen bond acceptor, increase basicity

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PDB entries from 2024-07-24

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