8RMN
Cryo-EM structure of a dimer of decameric human CALHM4 in complex with synthetic nanobody SbC4
Functional Information from PROSITE/UniProt
| site_id | PS01186 |
| Number of Residues | 15 |
| Details | EGF_2 EGF-like domain signature 2. CsCapPYrrisple.C |
| Chain | Residue | Details |
| A | CYS83-CYS97 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 440 |
| Details | TRANSMEM: Helical; Name=S1 => ECO:0000269|PubMed:32374262, ECO:0007744|PDB:6YTK |
| Chain | Residue | Details |
| A | ASN15-SER37 | |
| J | ASN15-SER37 | |
| K | ASN15-SER37 | |
| L | ASN15-SER37 | |
| M | ASN15-SER37 | |
| N | ASN15-SER37 | |
| O | ASN15-SER37 | |
| P | ASN15-SER37 | |
| Q | ASN15-SER37 | |
| R | ASN15-SER37 | |
| S | ASN15-SER37 | |
| B | ASN15-SER37 | |
| T | ASN15-SER37 | |
| C | ASN15-SER37 | |
| D | ASN15-SER37 | |
| E | ASN15-SER37 | |
| F | ASN15-SER37 | |
| G | ASN15-SER37 | |
| H | ASN15-SER37 | |
| I | ASN15-SER37 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1260 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | THR38-ASN48 | |
| E | GLU130-TYR183 | |
| F | THR38-ASN48 | |
| F | GLU130-TYR183 | |
| G | THR38-ASN48 | |
| G | GLU130-TYR183 | |
| H | THR38-ASN48 | |
| H | GLU130-TYR183 | |
| I | THR38-ASN48 | |
| I | GLU130-TYR183 | |
| J | THR38-ASN48 | |
| A | GLU130-TYR183 | |
| J | GLU130-TYR183 | |
| K | THR38-ASN48 | |
| K | GLU130-TYR183 | |
| L | THR38-ASN48 | |
| L | GLU130-TYR183 | |
| M | THR38-ASN48 | |
| M | GLU130-TYR183 | |
| N | THR38-ASN48 | |
| N | GLU130-TYR183 | |
| O | THR38-ASN48 | |
| B | THR38-ASN48 | |
| O | GLU130-TYR183 | |
| P | THR38-ASN48 | |
| P | GLU130-TYR183 | |
| Q | THR38-ASN48 | |
| Q | GLU130-TYR183 | |
| R | THR38-ASN48 | |
| R | GLU130-TYR183 | |
| S | THR38-ASN48 | |
| S | GLU130-TYR183 | |
| T | THR38-ASN48 | |
| B | GLU130-TYR183 | |
| T | GLU130-TYR183 | |
| C | THR38-ASN48 | |
| C | GLU130-TYR183 | |
| D | THR38-ASN48 | |
| D | GLU130-TYR183 | |
| E | THR38-ASN48 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 440 |
| Details | TRANSMEM: Helical; Name=S2 => ECO:0000269|PubMed:32374262, ECO:0007744|PDB:6YTK |
| Chain | Residue | Details |
| A | PHE49-ARG71 | |
| J | PHE49-ARG71 | |
| K | PHE49-ARG71 | |
| L | PHE49-ARG71 | |
| M | PHE49-ARG71 | |
| N | PHE49-ARG71 | |
| O | PHE49-ARG71 | |
| P | PHE49-ARG71 | |
| Q | PHE49-ARG71 | |
| R | PHE49-ARG71 | |
| S | PHE49-ARG71 | |
| B | PHE49-ARG71 | |
| T | PHE49-ARG71 | |
| C | PHE49-ARG71 | |
| D | PHE49-ARG71 | |
| E | PHE49-ARG71 | |
| F | PHE49-ARG71 | |
| G | PHE49-ARG71 | |
| H | PHE49-ARG71 | |
| I | PHE49-ARG71 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2740 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | SER72-ARG103 | |
| E | LYS208-PRO314 | |
| F | SER72-ARG103 | |
| F | LYS208-PRO314 | |
| G | SER72-ARG103 | |
| G | LYS208-PRO314 | |
| H | SER72-ARG103 | |
| H | LYS208-PRO314 | |
| I | SER72-ARG103 | |
| I | LYS208-PRO314 | |
| J | SER72-ARG103 | |
| A | LYS208-PRO314 | |
| J | LYS208-PRO314 | |
| K | SER72-ARG103 | |
| K | LYS208-PRO314 | |
| L | SER72-ARG103 | |
| L | LYS208-PRO314 | |
| M | SER72-ARG103 | |
| M | LYS208-PRO314 | |
| N | SER72-ARG103 | |
| N | LYS208-PRO314 | |
| O | SER72-ARG103 | |
| B | SER72-ARG103 | |
| O | LYS208-PRO314 | |
| P | SER72-ARG103 | |
| P | LYS208-PRO314 | |
| Q | SER72-ARG103 | |
| Q | LYS208-PRO314 | |
| R | SER72-ARG103 | |
| R | LYS208-PRO314 | |
| S | SER72-ARG103 | |
| S | LYS208-PRO314 | |
| T | SER72-ARG103 | |
| B | LYS208-PRO314 | |
| T | LYS208-PRO314 | |
| C | SER72-ARG103 | |
| C | LYS208-PRO314 | |
| D | SER72-ARG103 | |
| D | LYS208-PRO314 | |
| E | SER72-ARG103 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 500 |
| Details | TRANSMEM: Helical; Name=S3 => ECO:0000269|PubMed:32374262, ECO:0007744|PDB:6YTK |
| Chain | Residue | Details |
| A | PHE104-TYR129 | |
| J | PHE104-TYR129 | |
| K | PHE104-TYR129 | |
| L | PHE104-TYR129 | |
| M | PHE104-TYR129 | |
| N | PHE104-TYR129 | |
| O | PHE104-TYR129 | |
| P | PHE104-TYR129 | |
| Q | PHE104-TYR129 | |
| R | PHE104-TYR129 | |
| S | PHE104-TYR129 | |
| B | PHE104-TYR129 | |
| T | PHE104-TYR129 | |
| C | PHE104-TYR129 | |
| D | PHE104-TYR129 | |
| E | PHE104-TYR129 | |
| F | PHE104-TYR129 | |
| G | PHE104-TYR129 | |
| H | PHE104-TYR129 | |
| I | PHE104-TYR129 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 460 |
| Details | TRANSMEM: Helical; Name=S4 => ECO:0000269|PubMed:32374262, ECO:0007744|PDB:6YTK |
| Chain | Residue | Details |
| A | GLN184-ALA207 | |
| J | GLN184-ALA207 | |
| K | GLN184-ALA207 | |
| L | GLN184-ALA207 | |
| M | GLN184-ALA207 | |
| N | GLN184-ALA207 | |
| O | GLN184-ALA207 | |
| P | GLN184-ALA207 | |
| Q | GLN184-ALA207 | |
| R | GLN184-ALA207 | |
| S | GLN184-ALA207 | |
| B | GLN184-ALA207 | |
| T | GLN184-ALA207 | |
| C | GLN184-ALA207 | |
| D | GLN184-ALA207 | |
| E | GLN184-ALA207 | |
| F | GLN184-ALA207 | |
| G | GLN184-ALA207 | |
| H | GLN184-ALA207 | |
| I | GLN184-ALA207 |
