8RIY

Human NUDT5 with ibrutinib derivative

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0000287	molecular_function	magnesium ion binding
AAA	0005515	molecular_function	protein binding
AAA	0005634	cellular_component	nucleus
AAA	0005829	cellular_component	cytosol
AAA	0006338	biological_process	chromatin remodeling
AAA	0006753	biological_process	nucleoside phosphate metabolic process
AAA	0009117	biological_process	nucleotide metabolic process
AAA	0009191	biological_process	ribonucleoside diphosphate catabolic process
AAA	0016779	molecular_function	nucleotidyltransferase activity
AAA	0016787	molecular_function	hydrolase activity
AAA	0017110	molecular_function	nucleoside diphosphate phosphatase activity
AAA	0019144	molecular_function	ADP-sugar pyrophosphatase activity
AAA	0019303	biological_process	D-ribose catabolic process
AAA	0019693	biological_process	ribose phosphate metabolic process
AAA	0030515	molecular_function	snoRNA binding
AAA	0042802	molecular_function	identical protein binding
AAA	0042803	molecular_function	protein homodimerization activity
AAA	0044715	molecular_function	8-oxo-dGDP phosphatase activity
AAA	0047631	molecular_function	ADP-ribose diphosphatase activity
AAA	0055086	biological_process	nucleobase-containing small molecule metabolic process
AAA	0070062	cellular_component	extracellular exosome
AAA	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
AAA	1990966	biological_process	ATP generation from poly-ADP-D-ribose
BBB	0000287	molecular_function	magnesium ion binding
BBB	0005515	molecular_function	protein binding
BBB	0005634	cellular_component	nucleus
BBB	0005829	cellular_component	cytosol
BBB	0006338	biological_process	chromatin remodeling
BBB	0006753	biological_process	nucleoside phosphate metabolic process
BBB	0009117	biological_process	nucleotide metabolic process
BBB	0009191	biological_process	ribonucleoside diphosphate catabolic process
BBB	0016779	molecular_function	nucleotidyltransferase activity
BBB	0016787	molecular_function	hydrolase activity
BBB	0017110	molecular_function	nucleoside diphosphate phosphatase activity
BBB	0019144	molecular_function	ADP-sugar pyrophosphatase activity
BBB	0019303	biological_process	D-ribose catabolic process
BBB	0019693	biological_process	ribose phosphate metabolic process
BBB	0030515	molecular_function	snoRNA binding
BBB	0042802	molecular_function	identical protein binding
BBB	0042803	molecular_function	protein homodimerization activity
BBB	0044715	molecular_function	8-oxo-dGDP phosphatase activity
BBB	0047631	molecular_function	ADP-ribose diphosphatase activity
BBB	0055086	biological_process	nucleobase-containing small molecule metabolic process
BBB	0070062	cellular_component	extracellular exosome
BBB	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
BBB	1990966	biological_process	ATP generation from poly-ADP-D-ribose

Functional Information from PROSITE/UniProt

site_id	PS00893
Number of Residues	22
Details	NUDIX_BOX Nudix box signature. GliddgEtpeaAAlRELeEEtG

Chain	Residue	Details
AAA	GLY97-GLY118

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	280
Details	Domain: {"description":"Nudix hydrolase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	42
Details	Motif: {"description":"Nudix box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21768126","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3L85","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"21768126","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3L85","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Binding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"17052728","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18462755","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DSC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BM4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17052728","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18462755","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DSC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BM4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17052728","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18462755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21768126","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"27257257","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---