8RGH

Structure of dynein-2 intermediate chain DYNC2I1 (WDR60) in complex with the dynein-2 heavy chain DYNC2H1.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001673	cellular_component	male germ cell nucleus
A	0003774	molecular_function	cytoskeletal motor activity
A	0003824	molecular_function	catalytic activity
A	0003908	molecular_function	methylated-DNA-[protein]-cysteine S-methyltransferase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005794	cellular_component	Golgi apparatus
A	0005868	cellular_component	cytoplasmic dynein complex
A	0005874	cellular_component	microtubule
A	0005886	cellular_component	plasma membrane
A	0005929	cellular_component	cilium
A	0005930	cellular_component	axoneme
A	0006281	biological_process	DNA repair
A	0007018	biological_process	microtubule-based movement
A	0007030	biological_process	Golgi organization
A	0008569	molecular_function	minus-end-directed microtubule motor activity
A	0030030	biological_process	cell projection organization
A	0030286	cellular_component	dynein complex
A	0031514	cellular_component	motile cilium
A	0035721	biological_process	intraciliary retrograde transport
A	0045177	cellular_component	apical part of cell
A	0045505	molecular_function	dynein intermediate chain binding
A	0051959	molecular_function	dynein light intermediate chain binding
A	0060271	biological_process	cilium assembly
A	0060294	biological_process	cilium movement involved in cell motility
A	0070062	cellular_component	extracellular exosome
A	0097542	cellular_component	ciliary tip
A	0097729	cellular_component	9+2 motile cilium
C	0000242	cellular_component	pericentriolar material
C	0000922	cellular_component	spindle pole
C	0001673	cellular_component	male germ cell nucleus
C	0005515	molecular_function	protein binding
C	0005615	cellular_component	extracellular space
C	0005813	cellular_component	centrosome
C	0005868	cellular_component	cytoplasmic dynein complex
C	0005929	cellular_component	cilium
C	0030030	biological_process	cell projection organization
C	0031021	cellular_component	interphase microtubule organizing center
C	0035721	biological_process	intraciliary retrograde transport
C	0042073	biological_process	intraciliary transport
C	0045503	molecular_function	dynein light chain binding
C	0045504	molecular_function	dynein heavy chain binding
C	0048704	biological_process	embryonic skeletal system morphogenesis
C	0060271	biological_process	cilium assembly
C	0097542	cellular_component	ciliary tip
C	0097546	cellular_component	ciliary base
D	0001673	cellular_component	male germ cell nucleus
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005813	cellular_component	centrosome
D	0005814	cellular_component	centriole
D	0005829	cellular_component	cytosol
D	0005868	cellular_component	cytoplasmic dynein complex
D	0005929	cellular_component	cilium
D	0005930	cellular_component	axoneme
D	0030175	cellular_component	filopodium
D	0035721	biological_process	intraciliary retrograde transport
D	0036064	cellular_component	ciliary basal body
D	0042073	biological_process	intraciliary transport
D	0045503	molecular_function	dynein light chain binding
D	0045504	molecular_function	dynein heavy chain binding
D	0060271	biological_process	cilium assembly
D	0097014	cellular_component	ciliary plasm
D	0097542	cellular_component	ciliary tip
E	0001673	cellular_component	male germ cell nucleus
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005794	cellular_component	Golgi apparatus
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0005868	cellular_component	cytoplasmic dynein complex
E	0005874	cellular_component	microtubule
E	0005881	cellular_component	cytoplasmic microtubule
E	0005929	cellular_component	cilium
E	0005930	cellular_component	axoneme
E	0030030	biological_process	cell projection organization
E	0030286	cellular_component	dynein complex
E	0031514	cellular_component	motile cilium
E	0035721	biological_process	intraciliary retrograde transport
E	0035735	biological_process	intraciliary transport involved in cilium assembly
E	0035869	cellular_component	ciliary transition zone
E	0036064	cellular_component	ciliary basal body
E	0045177	cellular_component	apical part of cell
E	0045504	molecular_function	dynein heavy chain binding
E	0097542	cellular_component	ciliary tip
E	1902017	biological_process	regulation of cilium assembly
G	0003777	molecular_function	microtubule motor activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005813	cellular_component	centrosome
G	0005856	cellular_component	cytoskeleton
G	0005868	cellular_component	cytoplasmic dynein complex
G	0005874	cellular_component	microtubule
G	0005929	cellular_component	cilium
G	0007018	biological_process	microtubule-based movement
G	0007632	biological_process	visual behavior
G	0016020	cellular_component	membrane
G	0030286	cellular_component	dynein complex
G	0032388	biological_process	positive regulation of intracellular transport
G	0035721	biological_process	intraciliary retrograde transport
G	0042802	molecular_function	identical protein binding
G	0045505	molecular_function	dynein intermediate chain binding
G	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
G	0097542	cellular_component	ciliary tip
H	0003777	molecular_function	microtubule motor activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005813	cellular_component	centrosome
H	0005856	cellular_component	cytoskeleton
H	0005868	cellular_component	cytoplasmic dynein complex
H	0005874	cellular_component	microtubule
H	0005929	cellular_component	cilium
H	0007018	biological_process	microtubule-based movement
H	0007632	biological_process	visual behavior
H	0016020	cellular_component	membrane
H	0030286	cellular_component	dynein complex
H	0032388	biological_process	positive regulation of intracellular transport
H	0035721	biological_process	intraciliary retrograde transport
H	0042802	molecular_function	identical protein binding
H	0045505	molecular_function	dynein intermediate chain binding
H	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
H	0097542	cellular_component	ciliary tip

Functional Information from PROSITE/UniProt

site_id	PS00374
Number of Residues	7
Details	MGMT Methylated-DNA--protein-cysteine methyltransferase active site. IPCHRVV

Chain	Residue	Details
A	ILE-63-VAL-57

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Repeat: {"description":"WD 1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	40
Details	Repeat: {"description":"WD 3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	40
Details	Repeat: {"description":"WD 4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	25
Details	Region: {"description":"DYNLRB1 binding","evidences":[{"source":"PubMed","id":"30649997","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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