8R1G

Dimeric ternary structure of E6AP-E6-p53

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000209	biological_process	protein polyubiquitination
A	0000502	cellular_component	proteasome complex
A	0001541	biological_process	ovarian follicle development
A	0003713	molecular_function	transcription coactivator activity
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006508	biological_process	proteolysis
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0007420	biological_process	brain development
A	0008021	cellular_component	synaptic vesicle
A	0016567	biological_process	protein ubiquitination
A	0016740	molecular_function	transferase activity
A	0030521	biological_process	androgen receptor signaling pathway
A	0031398	biological_process	positive regulation of protein ubiquitination
A	0032570	biological_process	response to progesterone
A	0035037	biological_process	sperm entry
A	0035641	biological_process	locomotory exploration behavior
A	0042220	biological_process	response to cocaine
A	0042542	biological_process	response to hydrogen peroxide
A	0042752	biological_process	regulation of circadian rhythm
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046872	molecular_function	metal ion binding
A	0048167	biological_process	regulation of synaptic plasticity
A	0048511	biological_process	rhythmic process
A	0050804	biological_process	modulation of chemical synaptic transmission
A	0050847	biological_process	progesterone receptor signaling pathway
A	0051865	biological_process	protein autoubiquitination
A	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0060736	biological_process	prostate gland growth
A	0061002	biological_process	negative regulation of dendritic spine morphogenesis
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0061743	biological_process	motor learning
A	0070936	biological_process	protein K48-linked ubiquitination
A	0098978	cellular_component	glutamatergic synapse
A	0099524	cellular_component	postsynaptic cytosol
A	1904262	biological_process	negative regulation of TORC1 signaling
A	1905528	biological_process	positive regulation of Golgi lumen acidification
A	1990416	biological_process	cellular response to brain-derived neurotrophic factor stimulus
A	2000058	biological_process	regulation of ubiquitin-dependent protein catabolic process
B	0000794	cellular_component	condensed nuclear chromosome
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005940	cellular_component	septin ring
B	0006351	biological_process	DNA-templated transcription
B	0006355	biological_process	regulation of DNA-templated transcription
B	0016925	biological_process	protein sumoylation
B	0019049	biological_process	virus-mediated perturbation of host defense response
B	0030162	biological_process	regulation of proteolysis
B	0030165	molecular_function	PDZ domain binding
B	0030430	cellular_component	host cell cytoplasm
B	0031386	molecular_function	protein tag activity
B	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
B	0039548	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
B	0039648	biological_process	symbiont-mediated perturbation of host ubiquitin-like protein modification
B	0039653	biological_process	symbiont-mediated suppression of host transcription
B	0042025	cellular_component	host cell nucleus
B	0042802	molecular_function	identical protein binding
B	0044389	molecular_function	ubiquitin-like protein ligase binding
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0046872	molecular_function	metal ion binding
B	0052150	biological_process	symbiont-mediated perturbation of host apoptosis
B	0090630	biological_process	activation of GTPase activity
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000423	biological_process	mitophagy
C	0000785	cellular_component	chromatin
C	0000976	molecular_function	transcription cis-regulatory region binding
C	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
C	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
C	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
C	0000987	molecular_function	cis-regulatory region sequence-specific DNA binding
C	0001046	molecular_function	core promoter sequence-specific DNA binding
C	0001094	molecular_function	TFIID-class transcription factor complex binding
C	0001227	molecular_function	DNA-binding transcription repressor activity, RNA polymerase II-specific
C	0001228	molecular_function	DNA-binding transcription activator activity, RNA polymerase II-specific
C	0001701	biological_process	in utero embryonic development
C	0001756	biological_process	somitogenesis
C	0001836	biological_process	release of cytochrome c from mitochondria
C	0002020	molecular_function	protease binding
C	0002039	molecular_function	p53 binding
C	0002244	biological_process	hematopoietic progenitor cell differentiation
C	0002309	biological_process	T cell proliferation involved in immune response
C	0002326	biological_process	B cell lineage commitment
C	0002360	biological_process	T cell lineage commitment
C	0002931	biological_process	response to ischemia
C	0003677	molecular_function	DNA binding
C	0003682	molecular_function	chromatin binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0003730	molecular_function	mRNA 3'-UTR binding
C	0005507	molecular_function	copper ion binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005657	cellular_component	replication fork
C	0005667	cellular_component	transcription regulator complex
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005783	cellular_component	endoplasmic reticulum
C	0005813	cellular_component	centrosome
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0006289	biological_process	nucleotide-excision repair
C	0006302	biological_process	double-strand break repair
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0006606	biological_process	protein import into nucleus
C	0006914	biological_process	autophagy
C	0006915	biological_process	apoptotic process
C	0006974	biological_process	DNA damage response
C	0006977	biological_process	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
C	0006978	biological_process	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
C	0006979	biological_process	response to oxidative stress
C	0006983	biological_process	ER overload response
C	0007179	biological_process	transforming growth factor beta receptor signaling pathway
C	0007265	biological_process	Ras protein signal transduction
C	0007346	biological_process	regulation of mitotic cell cycle
C	0007369	biological_process	gastrulation
C	0007405	biological_process	neuroblast proliferation
C	0007406	biological_process	negative regulation of neuroblast proliferation
C	0007417	biological_process	central nervous system development
C	0007507	biological_process	heart development
C	0007623	biological_process	circadian rhythm
C	0008104	biological_process	protein localization
C	0008156	biological_process	negative regulation of DNA replication
C	0008270	molecular_function	zinc ion binding
C	0008283	biological_process	cell population proliferation
C	0008285	biological_process	negative regulation of cell population proliferation
C	0008340	biological_process	determination of adult lifespan
C	0009299	biological_process	mRNA transcription
C	0009303	biological_process	rRNA transcription
C	0009410	biological_process	response to xenobiotic stimulus
C	0009411	biological_process	response to UV
C	0009651	biological_process	response to salt stress
C	0009792	biological_process	embryo development ending in birth or egg hatching
C	0010165	biological_process	response to X-ray
C	0010332	biological_process	response to gamma radiation
C	0010628	biological_process	positive regulation of gene expression
C	0010629	biological_process	negative regulation of gene expression
C	0010659	biological_process	cardiac muscle cell apoptotic process
C	0010666	biological_process	positive regulation of cardiac muscle cell apoptotic process
C	0014009	biological_process	glial cell proliferation
C	0016032	biological_process	viral process
C	0016363	cellular_component	nuclear matrix
C	0016604	cellular_component	nuclear body
C	0016605	cellular_component	PML body
C	0017053	cellular_component	transcription repressor complex
C	0019661	biological_process	glucose catabolic process to lactate via pyruvate
C	0019899	molecular_function	enzyme binding
C	0021549	biological_process	cerebellum development
C	0030308	biological_process	negative regulation of cell growth
C	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
C	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
C	0030971	molecular_function	receptor tyrosine kinase binding
C	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0032211	biological_process	negative regulation of telomere maintenance via telomerase
C	0032991	cellular_component	protein-containing complex
C	0033077	biological_process	T cell differentiation in thymus
C	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
C	0033554	biological_process	cellular response to stress
C	0034103	biological_process	regulation of tissue remodeling
C	0034644	biological_process	cellular response to UV
C	0035033	molecular_function	histone deacetylase regulator activity
C	0035264	biological_process	multicellular organism growth
C	0035794	biological_process	positive regulation of mitochondrial membrane permeability
C	0035861	cellular_component	site of double-strand break
C	0036310	molecular_function	ATP-dependent DNA/DNA annealing activity
C	0042127	biological_process	regulation of cell population proliferation
C	0042149	biological_process	cellular response to glucose starvation
C	0042771	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
C	0042802	molecular_function	identical protein binding
C	0042826	molecular_function	histone deacetylase binding
C	0042981	biological_process	regulation of apoptotic process
C	0043065	biological_process	positive regulation of apoptotic process
C	0043066	biological_process	negative regulation of apoptotic process
C	0043073	cellular_component	germ cell nucleus
C	0043153	biological_process	entrainment of circadian clock by photoperiod
C	0043504	biological_process	mitochondrial DNA repair
C	0043516	biological_process	regulation of DNA damage response, signal transduction by p53 class mediator
C	0043523	biological_process	regulation of neuron apoptotic process
C	0043525	biological_process	positive regulation of neuron apoptotic process
C	0043621	molecular_function	obsolete protein self-association
C	0045815	biological_process	transcription initiation-coupled chromatin remodeling
C	0045861	biological_process	negative regulation of proteolysis
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
C	0045930	biological_process	negative regulation of mitotic cell cycle
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0046677	biological_process	response to antibiotic
C	0046872	molecular_function	metal ion binding
C	0046982	molecular_function	protein heterodimerization activity
C	0048144	biological_process	fibroblast proliferation
C	0048147	biological_process	negative regulation of fibroblast proliferation
C	0048511	biological_process	rhythmic process
C	0048512	biological_process	circadian behavior
C	0048539	biological_process	bone marrow development
C	0048568	biological_process	embryonic organ development
C	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
C	0050821	biological_process	protein stabilization
C	0051087	molecular_function	protein-folding chaperone binding
C	0051097	biological_process	negative regulation of helicase activity
C	0051262	biological_process	protein tetramerization
C	0051276	biological_process	chromosome organization
C	0051402	biological_process	neuron apoptotic process
C	0051721	molecular_function	protein phosphatase 2A binding
C	0051726	biological_process	regulation of cell cycle
C	0060218	biological_process	hematopoietic stem cell differentiation
C	0060253	biological_process	negative regulation of glial cell proliferation
C	0060333	biological_process	type II interferon-mediated signaling pathway
C	0060411	biological_process	cardiac septum morphogenesis
C	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
C	0062100	biological_process	positive regulation of programmed necrotic cell death
C	0065003	biological_process	protein-containing complex assembly
C	0070059	biological_process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
C	0070242	biological_process	thymocyte apoptotic process
C	0070243	biological_process	regulation of thymocyte apoptotic process
C	0070245	biological_process	positive regulation of thymocyte apoptotic process
C	0070266	biological_process	necroptotic process
C	0071456	biological_process	cellular response to hypoxia
C	0071466	biological_process	cellular response to xenobiotic stimulus
C	0071479	biological_process	cellular response to ionizing radiation
C	0071480	biological_process	cellular response to gamma radiation
C	0071494	biological_process	cellular response to UV-C
C	0071889	molecular_function	14-3-3 protein binding
C	0072089	biological_process	stem cell proliferation
C	0072331	biological_process	signal transduction by p53 class mediator
C	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
C	0072593	biological_process	reactive oxygen species metabolic process
C	0072717	biological_process	cellular response to actinomycin D
C	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
C	0090398	biological_process	cellular senescence
C	0090399	biological_process	replicative senescence
C	0090403	biological_process	oxidative stress-induced premature senescence
C	0097193	biological_process	intrinsic apoptotic signaling pathway
C	0097252	biological_process	oligodendrocyte apoptotic process
C	0097371	molecular_function	MDM2/MDM4 family protein binding
C	0097718	molecular_function	disordered domain specific binding
C	0140296	molecular_function	general transcription initiation factor binding
C	0140677	molecular_function	molecular function activator activity
C	0140693	molecular_function	molecular condensate scaffold activity
C	1900119	biological_process	positive regulation of execution phase of apoptosis
C	1901525	biological_process	negative regulation of mitophagy
C	1902108	biological_process	regulation of mitochondrial membrane permeability involved in apoptotic process
C	1902253	biological_process	regulation of intrinsic apoptotic signaling pathway by p53 class mediator
C	1902749	biological_process	regulation of cell cycle G2/M phase transition
C	1902895	biological_process	positive regulation of miRNA transcription
C	1903451	biological_process	negative regulation of G1 to G0 transition
C	1903799	biological_process	negative regulation of miRNA processing
C	1904024	biological_process	negative regulation of glucose catabolic process to lactate via pyruvate
C	1905856	biological_process	negative regulation of pentose-phosphate shunt
C	1990144	biological_process	intrinsic apoptotic signaling pathway in response to hypoxia
C	1990841	molecular_function	promoter-specific chromatin binding
C	2000269	biological_process	regulation of fibroblast apoptotic process
C	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
C	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
C	2000647	biological_process	negative regulation of stem cell proliferation
C	2000772	biological_process	regulation of cellular senescence
C	2000774	biological_process	positive regulation of cellular senescence
C	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
D	0000209	biological_process	protein polyubiquitination
D	0000502	cellular_component	proteasome complex
D	0001541	biological_process	ovarian follicle development
D	0003713	molecular_function	transcription coactivator activity
D	0004842	molecular_function	ubiquitin-protein transferase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006508	biological_process	proteolysis
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0007420	biological_process	brain development
D	0008021	cellular_component	synaptic vesicle
D	0016567	biological_process	protein ubiquitination
D	0016740	molecular_function	transferase activity
D	0030521	biological_process	androgen receptor signaling pathway
D	0031398	biological_process	positive regulation of protein ubiquitination
D	0032570	biological_process	response to progesterone
D	0035037	biological_process	sperm entry
D	0035641	biological_process	locomotory exploration behavior
D	0042220	biological_process	response to cocaine
D	0042542	biological_process	response to hydrogen peroxide
D	0042752	biological_process	regulation of circadian rhythm
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0046872	molecular_function	metal ion binding
D	0048167	biological_process	regulation of synaptic plasticity
D	0048511	biological_process	rhythmic process
D	0050804	biological_process	modulation of chemical synaptic transmission
D	0050847	biological_process	progesterone receptor signaling pathway
D	0051865	biological_process	protein autoubiquitination
D	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D	0060736	biological_process	prostate gland growth
D	0061002	biological_process	negative regulation of dendritic spine morphogenesis
D	0061630	molecular_function	ubiquitin protein ligase activity
D	0061743	biological_process	motor learning
D	0070936	biological_process	protein K48-linked ubiquitination
D	0098978	cellular_component	glutamatergic synapse
D	0099524	cellular_component	postsynaptic cytosol
D	1904262	biological_process	negative regulation of TORC1 signaling
D	1905528	biological_process	positive regulation of Golgi lumen acidification
D	1990416	biological_process	cellular response to brain-derived neurotrophic factor stimulus
D	2000058	biological_process	regulation of ubiquitin-dependent protein catabolic process
E	0000794	cellular_component	condensed nuclear chromosome
E	0003677	molecular_function	DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005940	cellular_component	septin ring
E	0006351	biological_process	DNA-templated transcription
E	0006355	biological_process	regulation of DNA-templated transcription
E	0016925	biological_process	protein sumoylation
E	0019049	biological_process	virus-mediated perturbation of host defense response
E	0030162	biological_process	regulation of proteolysis
E	0030165	molecular_function	PDZ domain binding
E	0030430	cellular_component	host cell cytoplasm
E	0031386	molecular_function	protein tag activity
E	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
E	0039548	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
E	0039648	biological_process	symbiont-mediated perturbation of host ubiquitin-like protein modification
E	0039653	biological_process	symbiont-mediated suppression of host transcription
E	0042025	cellular_component	host cell nucleus
E	0042802	molecular_function	identical protein binding
E	0044389	molecular_function	ubiquitin-like protein ligase binding
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0046872	molecular_function	metal ion binding
E	0052150	biological_process	symbiont-mediated perturbation of host apoptosis
E	0090630	biological_process	activation of GTPase activity
F	0000122	biological_process	negative regulation of transcription by RNA polymerase II
F	0000423	biological_process	mitophagy
F	0000785	cellular_component	chromatin
F	0000976	molecular_function	transcription cis-regulatory region binding
F	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
F	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
F	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
F	0000987	molecular_function	cis-regulatory region sequence-specific DNA binding
F	0001046	molecular_function	core promoter sequence-specific DNA binding
F	0001094	molecular_function	TFIID-class transcription factor complex binding
F	0001227	molecular_function	DNA-binding transcription repressor activity, RNA polymerase II-specific
F	0001228	molecular_function	DNA-binding transcription activator activity, RNA polymerase II-specific
F	0001701	biological_process	in utero embryonic development
F	0001756	biological_process	somitogenesis
F	0001836	biological_process	release of cytochrome c from mitochondria
F	0002020	molecular_function	protease binding
F	0002039	molecular_function	p53 binding
F	0002244	biological_process	hematopoietic progenitor cell differentiation
F	0002309	biological_process	T cell proliferation involved in immune response
F	0002326	biological_process	B cell lineage commitment
F	0002360	biological_process	T cell lineage commitment
F	0002931	biological_process	response to ischemia
F	0003677	molecular_function	DNA binding
F	0003682	molecular_function	chromatin binding
F	0003700	molecular_function	DNA-binding transcription factor activity
F	0003730	molecular_function	mRNA 3'-UTR binding
F	0005507	molecular_function	copper ion binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005657	cellular_component	replication fork
F	0005667	cellular_component	transcription regulator complex
F	0005730	cellular_component	nucleolus
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0005783	cellular_component	endoplasmic reticulum
F	0005813	cellular_component	centrosome
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0006289	biological_process	nucleotide-excision repair
F	0006302	biological_process	double-strand break repair
F	0006355	biological_process	regulation of DNA-templated transcription
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0006606	biological_process	protein import into nucleus
F	0006914	biological_process	autophagy
F	0006915	biological_process	apoptotic process
F	0006974	biological_process	DNA damage response
F	0006977	biological_process	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
F	0006978	biological_process	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
F	0006979	biological_process	response to oxidative stress
F	0006983	biological_process	ER overload response
F	0007179	biological_process	transforming growth factor beta receptor signaling pathway
F	0007265	biological_process	Ras protein signal transduction
F	0007346	biological_process	regulation of mitotic cell cycle
F	0007369	biological_process	gastrulation
F	0007405	biological_process	neuroblast proliferation
F	0007406	biological_process	negative regulation of neuroblast proliferation
F	0007417	biological_process	central nervous system development
F	0007507	biological_process	heart development
F	0007623	biological_process	circadian rhythm
F	0008104	biological_process	protein localization
F	0008156	biological_process	negative regulation of DNA replication
F	0008270	molecular_function	zinc ion binding
F	0008283	biological_process	cell population proliferation
F	0008285	biological_process	negative regulation of cell population proliferation
F	0008340	biological_process	determination of adult lifespan
F	0009299	biological_process	mRNA transcription
F	0009303	biological_process	rRNA transcription
F	0009410	biological_process	response to xenobiotic stimulus
F	0009411	biological_process	response to UV
F	0009651	biological_process	response to salt stress
F	0009792	biological_process	embryo development ending in birth or egg hatching
F	0010165	biological_process	response to X-ray
F	0010332	biological_process	response to gamma radiation
F	0010628	biological_process	positive regulation of gene expression
F	0010629	biological_process	negative regulation of gene expression
F	0010659	biological_process	cardiac muscle cell apoptotic process
F	0010666	biological_process	positive regulation of cardiac muscle cell apoptotic process
F	0014009	biological_process	glial cell proliferation
F	0016032	biological_process	viral process
F	0016363	cellular_component	nuclear matrix
F	0016604	cellular_component	nuclear body
F	0016605	cellular_component	PML body
F	0017053	cellular_component	transcription repressor complex
F	0019661	biological_process	glucose catabolic process to lactate via pyruvate
F	0019899	molecular_function	enzyme binding
F	0021549	biological_process	cerebellum development
F	0030308	biological_process	negative regulation of cell growth
F	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
F	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
F	0030971	molecular_function	receptor tyrosine kinase binding
F	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0032211	biological_process	negative regulation of telomere maintenance via telomerase
F	0032991	cellular_component	protein-containing complex
F	0033077	biological_process	T cell differentiation in thymus
F	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
F	0033554	biological_process	cellular response to stress
F	0034103	biological_process	regulation of tissue remodeling
F	0034644	biological_process	cellular response to UV
F	0035033	molecular_function	histone deacetylase regulator activity
F	0035264	biological_process	multicellular organism growth
F	0035794	biological_process	positive regulation of mitochondrial membrane permeability
F	0035861	cellular_component	site of double-strand break
F	0036310	molecular_function	ATP-dependent DNA/DNA annealing activity
F	0042127	biological_process	regulation of cell population proliferation
F	0042149	biological_process	cellular response to glucose starvation
F	0042771	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
F	0042802	molecular_function	identical protein binding
F	0042826	molecular_function	histone deacetylase binding
F	0042981	biological_process	regulation of apoptotic process
F	0043065	biological_process	positive regulation of apoptotic process
F	0043066	biological_process	negative regulation of apoptotic process
F	0043073	cellular_component	germ cell nucleus
F	0043153	biological_process	entrainment of circadian clock by photoperiod
F	0043504	biological_process	mitochondrial DNA repair
F	0043516	biological_process	regulation of DNA damage response, signal transduction by p53 class mediator
F	0043523	biological_process	regulation of neuron apoptotic process
F	0043525	biological_process	positive regulation of neuron apoptotic process
F	0043621	molecular_function	obsolete protein self-association
F	0045815	biological_process	transcription initiation-coupled chromatin remodeling
F	0045861	biological_process	negative regulation of proteolysis
F	0045892	biological_process	negative regulation of DNA-templated transcription
F	0045893	biological_process	positive regulation of DNA-templated transcription
F	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
F	0045930	biological_process	negative regulation of mitotic cell cycle
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0046677	biological_process	response to antibiotic
F	0046872	molecular_function	metal ion binding
F	0046982	molecular_function	protein heterodimerization activity
F	0048144	biological_process	fibroblast proliferation
F	0048147	biological_process	negative regulation of fibroblast proliferation
F	0048511	biological_process	rhythmic process
F	0048512	biological_process	circadian behavior
F	0048539	biological_process	bone marrow development
F	0048568	biological_process	embryonic organ development
F	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
F	0050821	biological_process	protein stabilization
F	0051087	molecular_function	protein-folding chaperone binding
F	0051097	biological_process	negative regulation of helicase activity
F	0051262	biological_process	protein tetramerization
F	0051276	biological_process	chromosome organization
F	0051402	biological_process	neuron apoptotic process
F	0051721	molecular_function	protein phosphatase 2A binding
F	0051726	biological_process	regulation of cell cycle
F	0060218	biological_process	hematopoietic stem cell differentiation
F	0060253	biological_process	negative regulation of glial cell proliferation
F	0060333	biological_process	type II interferon-mediated signaling pathway
F	0060411	biological_process	cardiac septum morphogenesis
F	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
F	0062100	biological_process	positive regulation of programmed necrotic cell death
F	0065003	biological_process	protein-containing complex assembly
F	0070059	biological_process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
F	0070242	biological_process	thymocyte apoptotic process
F	0070243	biological_process	regulation of thymocyte apoptotic process
F	0070245	biological_process	positive regulation of thymocyte apoptotic process
F	0070266	biological_process	necroptotic process
F	0071456	biological_process	cellular response to hypoxia
F	0071466	biological_process	cellular response to xenobiotic stimulus
F	0071479	biological_process	cellular response to ionizing radiation
F	0071480	biological_process	cellular response to gamma radiation
F	0071494	biological_process	cellular response to UV-C
F	0071889	molecular_function	14-3-3 protein binding
F	0072089	biological_process	stem cell proliferation
F	0072331	biological_process	signal transduction by p53 class mediator
F	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
F	0072593	biological_process	reactive oxygen species metabolic process
F	0072717	biological_process	cellular response to actinomycin D
F	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
F	0090398	biological_process	cellular senescence
F	0090399	biological_process	replicative senescence
F	0090403	biological_process	oxidative stress-induced premature senescence
F	0097193	biological_process	intrinsic apoptotic signaling pathway
F	0097252	biological_process	oligodendrocyte apoptotic process
F	0097371	molecular_function	MDM2/MDM4 family protein binding
F	0097718	molecular_function	disordered domain specific binding
F	0140296	molecular_function	general transcription initiation factor binding
F	0140677	molecular_function	molecular function activator activity
F	0140693	molecular_function	molecular condensate scaffold activity
F	1900119	biological_process	positive regulation of execution phase of apoptosis
F	1901525	biological_process	negative regulation of mitophagy
F	1902108	biological_process	regulation of mitochondrial membrane permeability involved in apoptotic process
F	1902253	biological_process	regulation of intrinsic apoptotic signaling pathway by p53 class mediator
F	1902749	biological_process	regulation of cell cycle G2/M phase transition
F	1902895	biological_process	positive regulation of miRNA transcription
F	1903451	biological_process	negative regulation of G1 to G0 transition
F	1903799	biological_process	negative regulation of miRNA processing
F	1904024	biological_process	negative regulation of glucose catabolic process to lactate via pyruvate
F	1905856	biological_process	negative regulation of pentose-phosphate shunt
F	1990144	biological_process	intrinsic apoptotic signaling pathway in response to hypoxia
F	1990841	molecular_function	promoter-specific chromatin binding
F	2000269	biological_process	regulation of fibroblast apoptotic process
F	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
F	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
F	2000647	biological_process	negative regulation of stem cell proliferation
F	2000772	biological_process	regulation of cellular senescence
F	2000774	biological_process	positive regulation of cellular senescence
F	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00348
Number of Residues	13
Details	P53 p53 family signature. MCNSSCMGGMNRR

Chain	Residue	Details
C	MET237-ARG249

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	380
Details	DNA_BIND: DNA_BIND => ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:18996393, ECO:0000269|PubMed:20364130

Chain	Residue	Details
C	THR102-LYS292
F	THR102-LYS292

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:14534297, ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:17015838, ECO:0000269|PubMed:18650397, ECO:0000269|PubMed:19515728, ECO:0000269|PubMed:20142040, ECO:0000269|PubMed:20364130

Chain	Residue	Details
C	CYS176
C	HIS179
C	CYS238
C	CYS242
F	CYS176
F	HIS179
F	CYS238
F	CYS242

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Interaction with DNA => ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:18996393, ECO:0000269|PubMed:20364130

Chain	Residue	Details
C	LYS120
F	LYS120
E	GLY-10

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine; by HIPK4 => ECO:0000269|PubMed:18022393

Chain	Residue	Details
C	SER9
F	SER9
E	CYS37-CYS73
E	CYS110-CYS146

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine; by CDK5, PRPK, AMPK, NUAK1 and ATM => ECO:0000269|PubMed:10570149, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17108107, ECO:0000269|PubMed:17591690, ECO:0000269|PubMed:17967874, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:28842590

Chain	Residue	Details
C	SER15
F	SER15

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by CK1, VRK1 and VRK2 => ECO:0000269|PubMed:10606744, ECO:0000269|PubMed:10951572, ECO:0000269|PubMed:16704422, ECO:0000269|PubMed:31527692

Chain	Residue	Details
C	THR18
F	THR18

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine; by CHEK2, CK1 and PLK3 => ECO:0000269|PubMed:10570149, ECO:0000269|PubMed:11447225, ECO:0000269|PubMed:11551930, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:20041275

Chain	Residue	Details
C	SER20
F	SER20

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine; by CDK5 and CDK7 => ECO:0000269|PubMed:17591690, ECO:0000269|PubMed:9372954

Chain	Residue	Details
C	SER33
F	SER33

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphoserine; by MAPKAPK5 => ECO:0000269|PubMed:17254968

Chain	Residue	Details
C	SER37
F	SER37

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: Phosphoserine; by CDK5, DYRK2, HIPK2 and PKC/PRKCG => ECO:0000269|PubMed:11740489, ECO:0000269|PubMed:11780126, ECO:0000269|PubMed:16377624, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:17591690

Chain	Residue	Details
C	SER46
F	SER46

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by TAF1 and GRK5 => ECO:0000269|PubMed:15053879, ECO:0000269|PubMed:20124405

Chain	Residue	Details
C	THR55
F	THR55

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:19854137, ECO:0000269|PubMed:23431171

Chain	Residue	Details
C	LYS120
F	LYS120

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	MOD_RES: Phosphoserine; by AURKB => ECO:0000269|PubMed:20959462

Chain	Residue	Details
C	SER183
C	SER269
F	SER183
F	SER269

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by AURKB => ECO:0000269|PubMed:20959462

Chain	Residue	Details
C	THR284
F	THR284

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:12724314

Chain	Residue	Details
C	LYS305
F	LYS305

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	MOD_RES: Phosphoserine; by AURKA, CDK1 and CDK2 => ECO:0000269|PubMed:10884347, ECO:0000269|PubMed:14702041

Chain	Residue	Details
C	SER315
F	SER315

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P02340

Chain	Residue	Details
C	LYS321
F	LYS321

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	MOD_RES: Omega-N-methylarginine; by PRMT5 => ECO:0000269|PubMed:19011621

Chain	Residue	Details
C	ARG333
F	ARG333

---

site_id	SWS_FT_FI19
Number of Residues	4
Details	MOD_RES: Symmetric dimethylarginine; by PRMT5 => ECO:0000269|PubMed:19011621

Chain	Residue	Details
C	ARG335
C	ARG337
F	ARG335
F	ARG337

---

site_id	SWS_FT_FI20
Number of Residues	2
Details	MOD_RES: N6-methyllysine; by SMYD2; alternate => ECO:0000269|PubMed:17108971, ECO:0000269|PubMed:22864287

Chain	Residue	Details
C	LYS370
F	LYS370

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	MOD_RES: N6-methyllysine; by SETD7 => ECO:0000269|PubMed:15525938, ECO:0000269|PubMed:16415881

Chain	Residue	Details
C	LYS372
F	LYS372

---

site_id	SWS_FT_FI22
Number of Residues	2
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:10656795

Chain	Residue	Details
C	LYS373
F	LYS373

---

site_id	SWS_FT_FI23
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:29474172, ECO:0007744|PubMed:19608861

Chain	Residue	Details
C	LYS381
F	LYS381

---

site_id	SWS_FT_FI24
Number of Residues	2
Details	MOD_RES: N6-methyllysine; by KMT5A; alternate => ECO:0000269|PubMed:17707234, ECO:0000269|PubMed:20870725, ECO:0000269|PubMed:22864287

Chain	Residue	Details
C	LYS382
F	LYS382

---

site_id	SWS_FT_FI25
Number of Residues	2
Details	MOD_RES: Phosphoserine; by CK2, CDK2 and NUAK1 => ECO:0000269|PubMed:10884347, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:17108107, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:22214662

Chain	Residue	Details
C	SER392
F	SER392

---

site_id	SWS_FT_FI26
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:21597459

Chain	Residue	Details
C	LYS24
F	LYS24

---

site_id	SWS_FT_FI27
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:11124955, ECO:0000269|PubMed:22214662, ECO:0000269|Ref.37

Chain	Residue	Details
C	LYS386
F	LYS386

---

site_id	SWS_FT_FI28
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19536131

Chain	Residue	Details
C	LYS291
C	LYS292
F	LYS291
F	LYS292

---

site_id	SWS_FT_FI29
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19033443

Chain	Residue	Details
C	LYS351
C	LYS357
F	LYS351
F	LYS357

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 438

Chain	Residue	Details
A	ARG529	unknown
A	GLU562	unknown
A	GLU573	unknown
A	ASP630	electrostatic stabiliser
A	HIS841
A	CYS843	covalent catalysis

---

site_id	MCSA2
Number of Residues	6
Details	M-CSA 438

Chain	Residue	Details
D	ARG529	unknown
D	GLU562	unknown
D	GLU573	unknown
D	ASP630	electrostatic stabiliser
D	HIS841
D	CYS843	covalent catalysis

---