8R1G

Dimeric ternary structure of E6AP-E6-p53

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000209	biological_process	protein polyubiquitination
A	0000502	cellular_component	proteasome complex
A	0003713	molecular_function	transcription coactivator activity
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006508	biological_process	proteolysis
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0007420	biological_process	brain development
A	0008021	cellular_component	synaptic vesicle
A	0008270	molecular_function	zinc ion binding
A	0010604	biological_process	positive regulation of macromolecule metabolic process
A	0016567	biological_process	protein ubiquitination
A	0016740	molecular_function	transferase activity
A	0030518	biological_process	nuclear receptor-mediated steroid hormone signaling pathway
A	0031398	biological_process	positive regulation of protein ubiquitination
A	0032570	biological_process	response to progesterone
A	0042752	biological_process	regulation of circadian rhythm
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0046872	molecular_function	metal ion binding
A	0048167	biological_process	regulation of synaptic plasticity
A	0048511	biological_process	rhythmic process
A	0048513	biological_process	animal organ development
A	0048731	biological_process	system development
A	0050804	biological_process	modulation of chemical synaptic transmission
A	0050847	biological_process	progesterone receptor signaling pathway
A	0051865	biological_process	protein autoubiquitination
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0070936	biological_process	protein K48-linked ubiquitination
A	0080090	biological_process	regulation of primary metabolic process
A	0098978	cellular_component	glutamatergic synapse
A	0099524	cellular_component	postsynaptic cytosol
A	1904262	biological_process	negative regulation of TORC1 signaling
A	1905528	biological_process	positive regulation of Golgi lumen acidification
A	2000058	biological_process	regulation of ubiquitin-dependent protein catabolic process
B	0000794	cellular_component	condensed nuclear chromosome
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005940	cellular_component	septin ring
B	0006351	biological_process	DNA-templated transcription
B	0006355	biological_process	regulation of DNA-templated transcription
B	0008270	molecular_function	zinc ion binding
B	0016925	biological_process	protein sumoylation
B	0030162	biological_process	regulation of proteolysis
B	0030165	molecular_function	PDZ domain binding
B	0030430	cellular_component	host cell cytoplasm
B	0031386	molecular_function	protein tag activity
B	0032489	biological_process	regulation of Cdc42 protein signal transduction
B	0033668	biological_process	symbiont-mediated suppression of host apoptosis
B	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
B	0039548	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
B	0039648	biological_process	symbiont-mediated perturbation of host ubiquitin-like protein modification
B	0039653	biological_process	symbiont-mediated suppression of host transcription
B	0042025	cellular_component	host cell nucleus
B	0042802	molecular_function	identical protein binding
B	0044389	molecular_function	ubiquitin-like protein ligase binding
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0046872	molecular_function	metal ion binding
B	0052031	biological_process	symbiont-mediated perturbation of host defense response
B	0052150	biological_process	symbiont-mediated perturbation of host apoptosis
B	0052170	biological_process	symbiont-mediated suppression of host innate immune response
B	0060255	biological_process	regulation of macromolecule metabolic process
B	0080090	biological_process	regulation of primary metabolic process
B	0140537	molecular_function	transcription regulator activator activity
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000785	cellular_component	chromatin
C	0000976	molecular_function	transcription cis-regulatory region binding
C	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
C	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
C	0000987	molecular_function	cis-regulatory region sequence-specific DNA binding
C	0001046	molecular_function	core promoter sequence-specific DNA binding
C	0001094	molecular_function	TFIID-class transcription factor complex binding
C	0001223	molecular_function	transcription coactivator binding
C	0001227	molecular_function	DNA-binding transcription repressor activity, RNA polymerase II-specific
C	0001228	molecular_function	DNA-binding transcription activator activity, RNA polymerase II-specific
C	0002020	molecular_function	protease binding
C	0002039	molecular_function	p53 binding
C	0002244	biological_process	hematopoietic progenitor cell differentiation
C	0003677	molecular_function	DNA binding
C	0003682	molecular_function	chromatin binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0003730	molecular_function	mRNA 3'-UTR binding
C	0005507	molecular_function	copper ion binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005667	cellular_component	transcription regulator complex
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005783	cellular_component	endoplasmic reticulum
C	0005813	cellular_component	centrosome
C	0005829	cellular_component	cytosol
C	0006289	biological_process	nucleotide-excision repair
C	0006351	biological_process	DNA-templated transcription
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0006914	biological_process	autophagy
C	0006915	biological_process	apoptotic process
C	0006974	biological_process	DNA damage response
C	0006979	biological_process	response to oxidative stress
C	0006983	biological_process	ER overload response
C	0007265	biological_process	Ras protein signal transduction
C	0007623	biological_process	circadian rhythm
C	0008104	biological_process	intracellular protein localization
C	0008270	molecular_function	zinc ion binding
C	0008285	biological_process	negative regulation of cell population proliferation
C	0008340	biological_process	determination of adult lifespan
C	0009299	biological_process	mRNA transcription
C	0009410	biological_process	response to xenobiotic stimulus
C	0009411	biological_process	response to UV
C	0010212	biological_process	response to ionizing radiation
C	0010332	biological_process	response to gamma radiation
C	0010628	biological_process	positive regulation of gene expression
C	0012501	biological_process	programmed cell death
C	0016032	biological_process	viral process
C	0016363	cellular_component	nuclear matrix
C	0016604	cellular_component	nuclear body
C	0016605	cellular_component	PML body
C	0019899	molecular_function	enzyme binding
C	0030308	biological_process	negative regulation of cell growth
C	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
C	0030971	molecular_function	receptor tyrosine kinase binding
C	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0032211	biological_process	negative regulation of telomere maintenance via telomerase
C	0032991	cellular_component	protein-containing complex
C	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
C	0034644	biological_process	cellular response to UV
C	0036310	molecular_function	ATP-dependent DNA/DNA annealing activity
C	0042149	biological_process	cellular response to glucose starvation
C	0042771	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
C	0042802	molecular_function	identical protein binding
C	0042826	molecular_function	histone deacetylase binding
C	0042981	biological_process	regulation of apoptotic process
C	0043065	biological_process	positive regulation of apoptotic process
C	0043066	biological_process	negative regulation of apoptotic process
C	0043153	biological_process	entrainment of circadian clock by photoperiod
C	0043621	molecular_function	obsolete protein self-association
C	0045815	biological_process	transcription initiation-coupled chromatin remodeling
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0046677	biological_process	response to antibiotic
C	0046872	molecular_function	metal ion binding
C	0046982	molecular_function	protein heterodimerization activity
C	0048147	biological_process	negative regulation of fibroblast proliferation
C	0048511	biological_process	rhythmic process
C	0048512	biological_process	circadian behavior
C	0048539	biological_process	bone marrow development
C	0051053	biological_process	negative regulation of DNA metabolic process
C	0051087	molecular_function	protein-folding chaperone binding
C	0051097	biological_process	negative regulation of helicase activity
C	0051262	biological_process	protein tetramerization
C	0051721	molecular_function	protein phosphatase 2A binding
C	0051726	biological_process	regulation of cell cycle
C	0060218	biological_process	hematopoietic stem cell differentiation
C	0060333	biological_process	type II interferon-mediated signaling pathway
C	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
C	0062100	biological_process	positive regulation of programmed necrotic cell death
C	0065003	biological_process	protein-containing complex assembly
C	0070059	biological_process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
C	0070245	biological_process	positive regulation of thymocyte apoptotic process
C	0071456	biological_process	cellular response to hypoxia
C	0071466	biological_process	cellular response to xenobiotic stimulus
C	0071479	biological_process	cellular response to ionizing radiation
C	0071480	biological_process	cellular response to gamma radiation
C	0071889	molecular_function	14-3-3 protein binding
C	0072331	biological_process	signal transduction by p53 class mediator
C	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
C	0072717	biological_process	cellular response to actinomycin D
C	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
C	0090398	biological_process	cellular senescence
C	0090399	biological_process	replicative senescence
C	0090403	biological_process	oxidative stress-induced premature senescence
C	0097190	biological_process	apoptotic signaling pathway
C	0097193	biological_process	intrinsic apoptotic signaling pathway
C	0097252	biological_process	oligodendrocyte apoptotic process
C	0097371	molecular_function	MDM2/MDM4 family protein binding
C	0097718	molecular_function	disordered domain specific binding
C	0140296	molecular_function	general transcription initiation factor binding
C	0140677	molecular_function	molecular function activator activity
C	0140693	molecular_function	molecular condensate scaffold activity
C	1900119	biological_process	positive regulation of execution phase of apoptosis
C	1902749	biological_process	regulation of cell cycle G2/M phase transition
C	1902895	biological_process	positive regulation of miRNA transcription
C	1903451	biological_process	negative regulation of G1 to G0 transition
C	1905856	biological_process	negative regulation of pentose-phosphate shunt
C	1990841	molecular_function	promoter-specific chromatin binding
C	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
C	2000774	biological_process	positive regulation of cellular senescence
C	2001242	biological_process	regulation of intrinsic apoptotic signaling pathway
C	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
D	0000209	biological_process	protein polyubiquitination
D	0000502	cellular_component	proteasome complex
D	0003713	molecular_function	transcription coactivator activity
D	0004842	molecular_function	ubiquitin-protein transferase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006508	biological_process	proteolysis
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0007420	biological_process	brain development
D	0008021	cellular_component	synaptic vesicle
D	0008270	molecular_function	zinc ion binding
D	0010604	biological_process	positive regulation of macromolecule metabolic process
D	0016567	biological_process	protein ubiquitination
D	0016740	molecular_function	transferase activity
D	0030518	biological_process	nuclear receptor-mediated steroid hormone signaling pathway
D	0031398	biological_process	positive regulation of protein ubiquitination
D	0032570	biological_process	response to progesterone
D	0042752	biological_process	regulation of circadian rhythm
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0046872	molecular_function	metal ion binding
D	0048167	biological_process	regulation of synaptic plasticity
D	0048511	biological_process	rhythmic process
D	0048513	biological_process	animal organ development
D	0048731	biological_process	system development
D	0050804	biological_process	modulation of chemical synaptic transmission
D	0050847	biological_process	progesterone receptor signaling pathway
D	0051865	biological_process	protein autoubiquitination
D	0061630	molecular_function	ubiquitin protein ligase activity
D	0070936	biological_process	protein K48-linked ubiquitination
D	0080090	biological_process	regulation of primary metabolic process
D	0098978	cellular_component	glutamatergic synapse
D	0099524	cellular_component	postsynaptic cytosol
D	1904262	biological_process	negative regulation of TORC1 signaling
D	1905528	biological_process	positive regulation of Golgi lumen acidification
D	2000058	biological_process	regulation of ubiquitin-dependent protein catabolic process
E	0000794	cellular_component	condensed nuclear chromosome
E	0003677	molecular_function	DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005940	cellular_component	septin ring
E	0006351	biological_process	DNA-templated transcription
E	0006355	biological_process	regulation of DNA-templated transcription
E	0008270	molecular_function	zinc ion binding
E	0016925	biological_process	protein sumoylation
E	0030162	biological_process	regulation of proteolysis
E	0030165	molecular_function	PDZ domain binding
E	0030430	cellular_component	host cell cytoplasm
E	0031386	molecular_function	protein tag activity
E	0032489	biological_process	regulation of Cdc42 protein signal transduction
E	0033668	biological_process	symbiont-mediated suppression of host apoptosis
E	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
E	0039548	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
E	0039648	biological_process	symbiont-mediated perturbation of host ubiquitin-like protein modification
E	0039653	biological_process	symbiont-mediated suppression of host transcription
E	0042025	cellular_component	host cell nucleus
E	0042802	molecular_function	identical protein binding
E	0044389	molecular_function	ubiquitin-like protein ligase binding
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0046872	molecular_function	metal ion binding
E	0052031	biological_process	symbiont-mediated perturbation of host defense response
E	0052150	biological_process	symbiont-mediated perturbation of host apoptosis
E	0052170	biological_process	symbiont-mediated suppression of host innate immune response
E	0060255	biological_process	regulation of macromolecule metabolic process
E	0080090	biological_process	regulation of primary metabolic process
E	0140537	molecular_function	transcription regulator activator activity
F	0000122	biological_process	negative regulation of transcription by RNA polymerase II
F	0000785	cellular_component	chromatin
F	0000976	molecular_function	transcription cis-regulatory region binding
F	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
F	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
F	0000987	molecular_function	cis-regulatory region sequence-specific DNA binding
F	0001046	molecular_function	core promoter sequence-specific DNA binding
F	0001094	molecular_function	TFIID-class transcription factor complex binding
F	0001223	molecular_function	transcription coactivator binding
F	0001227	molecular_function	DNA-binding transcription repressor activity, RNA polymerase II-specific
F	0001228	molecular_function	DNA-binding transcription activator activity, RNA polymerase II-specific
F	0002020	molecular_function	protease binding
F	0002039	molecular_function	p53 binding
F	0002244	biological_process	hematopoietic progenitor cell differentiation
F	0003677	molecular_function	DNA binding
F	0003682	molecular_function	chromatin binding
F	0003700	molecular_function	DNA-binding transcription factor activity
F	0003730	molecular_function	mRNA 3'-UTR binding
F	0005507	molecular_function	copper ion binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005667	cellular_component	transcription regulator complex
F	0005730	cellular_component	nucleolus
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0005783	cellular_component	endoplasmic reticulum
F	0005813	cellular_component	centrosome
F	0005829	cellular_component	cytosol
F	0006289	biological_process	nucleotide-excision repair
F	0006351	biological_process	DNA-templated transcription
F	0006355	biological_process	regulation of DNA-templated transcription
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0006914	biological_process	autophagy
F	0006915	biological_process	apoptotic process
F	0006974	biological_process	DNA damage response
F	0006979	biological_process	response to oxidative stress
F	0006983	biological_process	ER overload response
F	0007265	biological_process	Ras protein signal transduction
F	0007623	biological_process	circadian rhythm
F	0008104	biological_process	intracellular protein localization
F	0008270	molecular_function	zinc ion binding
F	0008285	biological_process	negative regulation of cell population proliferation
F	0008340	biological_process	determination of adult lifespan
F	0009299	biological_process	mRNA transcription
F	0009410	biological_process	response to xenobiotic stimulus
F	0009411	biological_process	response to UV
F	0010212	biological_process	response to ionizing radiation
F	0010332	biological_process	response to gamma radiation
F	0010628	biological_process	positive regulation of gene expression
F	0012501	biological_process	programmed cell death
F	0016032	biological_process	viral process
F	0016363	cellular_component	nuclear matrix
F	0016604	cellular_component	nuclear body
F	0016605	cellular_component	PML body
F	0019899	molecular_function	enzyme binding
F	0030308	biological_process	negative regulation of cell growth
F	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
F	0030971	molecular_function	receptor tyrosine kinase binding
F	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0032211	biological_process	negative regulation of telomere maintenance via telomerase
F	0032991	cellular_component	protein-containing complex
F	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
F	0034644	biological_process	cellular response to UV
F	0036310	molecular_function	ATP-dependent DNA/DNA annealing activity
F	0042149	biological_process	cellular response to glucose starvation
F	0042771	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
F	0042802	molecular_function	identical protein binding
F	0042826	molecular_function	histone deacetylase binding
F	0042981	biological_process	regulation of apoptotic process
F	0043065	biological_process	positive regulation of apoptotic process
F	0043066	biological_process	negative regulation of apoptotic process
F	0043153	biological_process	entrainment of circadian clock by photoperiod
F	0043621	molecular_function	obsolete protein self-association
F	0045815	biological_process	transcription initiation-coupled chromatin remodeling
F	0045892	biological_process	negative regulation of DNA-templated transcription
F	0045893	biological_process	positive regulation of DNA-templated transcription
F	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0046677	biological_process	response to antibiotic
F	0046872	molecular_function	metal ion binding
F	0046982	molecular_function	protein heterodimerization activity
F	0048147	biological_process	negative regulation of fibroblast proliferation
F	0048511	biological_process	rhythmic process
F	0048512	biological_process	circadian behavior
F	0048539	biological_process	bone marrow development
F	0051053	biological_process	negative regulation of DNA metabolic process
F	0051087	molecular_function	protein-folding chaperone binding
F	0051097	biological_process	negative regulation of helicase activity
F	0051262	biological_process	protein tetramerization
F	0051721	molecular_function	protein phosphatase 2A binding
F	0051726	biological_process	regulation of cell cycle
F	0060218	biological_process	hematopoietic stem cell differentiation
F	0060333	biological_process	type II interferon-mediated signaling pathway
F	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
F	0062100	biological_process	positive regulation of programmed necrotic cell death
F	0065003	biological_process	protein-containing complex assembly
F	0070059	biological_process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
F	0070245	biological_process	positive regulation of thymocyte apoptotic process
F	0071456	biological_process	cellular response to hypoxia
F	0071466	biological_process	cellular response to xenobiotic stimulus
F	0071479	biological_process	cellular response to ionizing radiation
F	0071480	biological_process	cellular response to gamma radiation
F	0071889	molecular_function	14-3-3 protein binding
F	0072331	biological_process	signal transduction by p53 class mediator
F	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
F	0072717	biological_process	cellular response to actinomycin D
F	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
F	0090398	biological_process	cellular senescence
F	0090399	biological_process	replicative senescence
F	0090403	biological_process	oxidative stress-induced premature senescence
F	0097190	biological_process	apoptotic signaling pathway
F	0097193	biological_process	intrinsic apoptotic signaling pathway
F	0097252	biological_process	oligodendrocyte apoptotic process
F	0097371	molecular_function	MDM2/MDM4 family protein binding
F	0097718	molecular_function	disordered domain specific binding
F	0140296	molecular_function	general transcription initiation factor binding
F	0140677	molecular_function	molecular function activator activity
F	0140693	molecular_function	molecular condensate scaffold activity
F	1900119	biological_process	positive regulation of execution phase of apoptosis
F	1902749	biological_process	regulation of cell cycle G2/M phase transition
F	1902895	biological_process	positive regulation of miRNA transcription
F	1903451	biological_process	negative regulation of G1 to G0 transition
F	1905856	biological_process	negative regulation of pentose-phosphate shunt
F	1990841	molecular_function	promoter-specific chromatin binding
F	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
F	2000774	biological_process	positive regulation of cellular senescence
F	2001242	biological_process	regulation of intrinsic apoptotic signaling pathway
F	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00348
Number of Residues	13
Details	P53 p53 family signature. MCNSSCMGGMNRR

Chain	Residue	Details
C	MET237-ARG249

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	34
Details	Region: {"description":"E6-binding"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	198
Details	Region: {"description":"Interaction with HCV core protein"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"Glycyl thioester intermediate"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; by ABL1","evidences":[{"source":"PubMed","id":"23581475","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	144
Details	Zinc finger: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04006","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	380
Details	DNA binding: {"evidences":[{"source":"PubMed","id":"16793544","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18996393","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20364130","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	246
Details	Region: {"description":"Required for interaction with FBXO42","evidences":[{"source":"PubMed","id":"19509332","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	352
Details	Region: {"description":"Interaction with AXIN1","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	14
Details	Region: {"description":"Interaction with the 53BP2 SH3 domain"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	14
Details	Region: {"description":"Interaction with DNA"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14534297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16793544","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17015838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18650397","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19515728","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20142040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20364130","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Site: {"description":"Interaction with DNA","evidences":[{"source":"PubMed","id":"16793544","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18996393","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20364130","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	Modified residue: {"description":"N6-lactoyllysine","evidences":[{"source":"PubMed","id":"38653238","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by AURKB","evidences":[{"source":"PubMed","id":"20959462","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by AURKB","evidences":[{"source":"PubMed","id":"20959462","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"19536131","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 438

Chain	Residue	Details
A	ARG529	unknown
A	GLU562	unknown
A	GLU573	unknown
A	ASP630	electrostatic stabiliser
A	HIS841
A	CYS843	covalent catalysis

---

site_id	MCSA2
Number of Residues	6
Details	M-CSA 438

Chain	Residue	Details
D	ARG529	unknown
D	GLU562	unknown
D	GLU573	unknown
D	ASP630	electrostatic stabiliser
D	HIS841
D	CYS843	covalent catalysis

---