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8R1F

Monomeric E6AP-E6-p53 ternary complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000209biological_processprotein polyubiquitination
A0000502cellular_componentproteasome complex
A0001541biological_processovarian follicle development
A0003713molecular_functiontranscription coactivator activity
A0004842molecular_functionubiquitin-protein transferase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006508biological_processproteolysis
A0006511biological_processubiquitin-dependent protein catabolic process
A0007420biological_processbrain development
A0008021cellular_componentsynaptic vesicle
A0016567biological_processprotein ubiquitination
A0016740molecular_functiontransferase activity
A0030521biological_processandrogen receptor signaling pathway
A0031398biological_processpositive regulation of protein ubiquitination
A0032570biological_processresponse to progesterone
A0035037biological_processsperm entry
A0035641biological_processlocomotory exploration behavior
A0042220biological_processresponse to cocaine
A0042542biological_processresponse to hydrogen peroxide
A0042752biological_processregulation of circadian rhythm
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046872molecular_functionmetal ion binding
A0048167biological_processregulation of synaptic plasticity
A0048511biological_processrhythmic process
A0050804biological_processmodulation of chemical synaptic transmission
A0050847biological_processprogesterone receptor signaling pathway
A0051865biological_processprotein autoubiquitination
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0060736biological_processprostate gland growth
A0061002biological_processnegative regulation of dendritic spine morphogenesis
A0061630molecular_functionubiquitin protein ligase activity
A0061743biological_processmotor learning
A0070936biological_processprotein K48-linked ubiquitination
A0098978cellular_componentglutamatergic synapse
A0099524cellular_componentpostsynaptic cytosol
A1904262biological_processnegative regulation of TORC1 signaling
A1905528biological_processpositive regulation of Golgi lumen acidification
A1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
A2000058biological_processregulation of ubiquitin-dependent protein catabolic process
B0000794cellular_componentcondensed nuclear chromosome
B0003677molecular_functionDNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005940cellular_componentseptin ring
B0006351biological_processDNA-templated transcription
B0006355biological_processregulation of DNA-templated transcription
B0016925biological_processprotein sumoylation
B0019049biological_processvirus-mediated perturbation of host defense response
B0030162biological_processregulation of proteolysis
B0030165molecular_functionPDZ domain binding
B0030430cellular_componenthost cell cytoplasm
B0031386molecular_functionprotein tag activity
B0039502biological_processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
B0039548biological_processsymbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
B0039648biological_processsymbiont-mediated perturbation of host ubiquitin-like protein modification
B0039653biological_processsymbiont-mediated suppression of host transcription
B0042025cellular_componenthost cell nucleus
B0042802molecular_functionidentical protein binding
B0044389molecular_functionubiquitin-like protein ligase binding
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046872molecular_functionmetal ion binding
B0052150biological_processsymbiont-mediated perturbation of host apoptosis
B0090630biological_processactivation of GTPase activity
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000423biological_processmitophagy
C0000785cellular_componentchromatin
C0000976molecular_functiontranscription cis-regulatory region binding
C0000977molecular_functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
C0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
C0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
C0000987molecular_functioncis-regulatory region sequence-specific DNA binding
C0001046molecular_functioncore promoter sequence-specific DNA binding
C0001094molecular_functionTFIID-class transcription factor complex binding
C0001227molecular_functionDNA-binding transcription repressor activity, RNA polymerase II-specific
C0001228molecular_functionDNA-binding transcription activator activity, RNA polymerase II-specific
C0001701biological_processin utero embryonic development
C0001756biological_processsomitogenesis
C0001836biological_processrelease of cytochrome c from mitochondria
C0002020molecular_functionprotease binding
C0002039molecular_functionp53 binding
C0002244biological_processhematopoietic progenitor cell differentiation
C0002309biological_processT cell proliferation involved in immune response
C0002326biological_processB cell lineage commitment
C0002360biological_processT cell lineage commitment
C0002931biological_processresponse to ischemia
C0003677molecular_functionDNA binding
C0003682molecular_functionchromatin binding
C0003700molecular_functionDNA-binding transcription factor activity
C0003730molecular_functionmRNA 3'-UTR binding
C0005507molecular_functioncopper ion binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005657cellular_componentreplication fork
C0005667cellular_componenttranscription regulator complex
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005759cellular_componentmitochondrial matrix
C0005783cellular_componentendoplasmic reticulum
C0005813cellular_componentcentrosome
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0006289biological_processnucleotide-excision repair
C0006302biological_processdouble-strand break repair
C0006355biological_processregulation of DNA-templated transcription
C0006357biological_processregulation of transcription by RNA polymerase II
C0006606biological_processprotein import into nucleus
C0006914biological_processautophagy
C0006915biological_processapoptotic process
C0006974biological_processDNA damage response
C0006977biological_processDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
C0006978biological_processDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
C0006979biological_processresponse to oxidative stress
C0006983biological_processER overload response
C0007179biological_processtransforming growth factor beta receptor signaling pathway
C0007265biological_processRas protein signal transduction
C0007346biological_processregulation of mitotic cell cycle
C0007369biological_processgastrulation
C0007405biological_processneuroblast proliferation
C0007406biological_processnegative regulation of neuroblast proliferation
C0007417biological_processcentral nervous system development
C0007507biological_processheart development
C0007623biological_processcircadian rhythm
C0008104biological_processprotein localization
C0008156biological_processnegative regulation of DNA replication
C0008270molecular_functionzinc ion binding
C0008283biological_processcell population proliferation
C0008285biological_processnegative regulation of cell population proliferation
C0008340biological_processdetermination of adult lifespan
C0009299biological_processmRNA transcription
C0009303biological_processrRNA transcription
C0009410biological_processresponse to xenobiotic stimulus
C0009411biological_processresponse to UV
C0009651biological_processresponse to salt stress
C0009792biological_processembryo development ending in birth or egg hatching
C0010165biological_processresponse to X-ray
C0010332biological_processresponse to gamma radiation
C0010628biological_processpositive regulation of gene expression
C0010629biological_processnegative regulation of gene expression
C0010659biological_processcardiac muscle cell apoptotic process
C0010666biological_processpositive regulation of cardiac muscle cell apoptotic process
C0014009biological_processglial cell proliferation
C0016032biological_processviral process
C0016363cellular_componentnuclear matrix
C0016604cellular_componentnuclear body
C0016605cellular_componentPML body
C0017053cellular_componenttranscription repressor complex
C0019661biological_processglucose catabolic process to lactate via pyruvate
C0019899molecular_functionenzyme binding
C0021549biological_processcerebellum development
C0030308biological_processnegative regulation of cell growth
C0030330biological_processDNA damage response, signal transduction by p53 class mediator
C0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
C0030971molecular_functionreceptor tyrosine kinase binding
C0031571biological_processmitotic G1 DNA damage checkpoint signaling
C0031625molecular_functionubiquitin protein ligase binding
C0032211biological_processnegative regulation of telomere maintenance via telomerase
C0032991cellular_componentprotein-containing complex
C0033077biological_processT cell differentiation in thymus
C0033209biological_processtumor necrosis factor-mediated signaling pathway
C0033554biological_processcellular response to stress
C0034103biological_processregulation of tissue remodeling
C0034644biological_processcellular response to UV
C0035033molecular_functionhistone deacetylase regulator activity
C0035264biological_processmulticellular organism growth
C0035794biological_processpositive regulation of mitochondrial membrane permeability
C0035861cellular_componentsite of double-strand break
C0036310molecular_functionATP-dependent DNA/DNA annealing activity
C0042127biological_processregulation of cell population proliferation
C0042149biological_processcellular response to glucose starvation
C0042771biological_processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
C0042802molecular_functionidentical protein binding
C0042826molecular_functionhistone deacetylase binding
C0042981biological_processregulation of apoptotic process
C0043065biological_processpositive regulation of apoptotic process
C0043066biological_processnegative regulation of apoptotic process
C0043073cellular_componentgerm cell nucleus
C0043153biological_processentrainment of circadian clock by photoperiod
C0043504biological_processmitochondrial DNA repair
C0043516biological_processregulation of DNA damage response, signal transduction by p53 class mediator
C0043523biological_processregulation of neuron apoptotic process
C0043525biological_processpositive regulation of neuron apoptotic process
C0043621molecular_functionobsolete protein self-association
C0045815biological_processtranscription initiation-coupled chromatin remodeling
C0045861biological_processnegative regulation of proteolysis
C0045892biological_processnegative regulation of DNA-templated transcription
C0045893biological_processpositive regulation of DNA-templated transcription
C0045899biological_processpositive regulation of RNA polymerase II transcription preinitiation complex assembly
C0045930biological_processnegative regulation of mitotic cell cycle
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0046677biological_processresponse to antibiotic
C0046872molecular_functionmetal ion binding
C0046982molecular_functionprotein heterodimerization activity
C0048144biological_processfibroblast proliferation
C0048147biological_processnegative regulation of fibroblast proliferation
C0048511biological_processrhythmic process
C0048512biological_processcircadian behavior
C0048539biological_processbone marrow development
C0048568biological_processembryonic organ development
C0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
C0050821biological_processprotein stabilization
C0051087molecular_functionprotein-folding chaperone binding
C0051097biological_processnegative regulation of helicase activity
C0051262biological_processprotein tetramerization
C0051276biological_processchromosome organization
C0051402biological_processneuron apoptotic process
C0051721molecular_functionprotein phosphatase 2A binding
C0051726biological_processregulation of cell cycle
C0060218biological_processhematopoietic stem cell differentiation
C0060253biological_processnegative regulation of glial cell proliferation
C0060333biological_processtype II interferon-mediated signaling pathway
C0060411biological_processcardiac septum morphogenesis
C0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
C0062100biological_processpositive regulation of programmed necrotic cell death
C0065003biological_processprotein-containing complex assembly
C0070059biological_processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
C0070242biological_processthymocyte apoptotic process
C0070243biological_processregulation of thymocyte apoptotic process
C0070245biological_processpositive regulation of thymocyte apoptotic process
C0070266biological_processnecroptotic process
C0071456biological_processcellular response to hypoxia
C0071466biological_processcellular response to xenobiotic stimulus
C0071479biological_processcellular response to ionizing radiation
C0071480biological_processcellular response to gamma radiation
C0071494biological_processcellular response to UV-C
C0071889molecular_function14-3-3 protein binding
C0072089biological_processstem cell proliferation
C0072331biological_processsignal transduction by p53 class mediator
C0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
C0072593biological_processreactive oxygen species metabolic process
C0072717biological_processcellular response to actinomycin D
C0090200biological_processpositive regulation of release of cytochrome c from mitochondria
C0090398biological_processcellular senescence
C0090399biological_processreplicative senescence
C0090403biological_processoxidative stress-induced premature senescence
C0097193biological_processintrinsic apoptotic signaling pathway
C0097252biological_processoligodendrocyte apoptotic process
C0097371molecular_functionMDM2/MDM4 family protein binding
C0097718molecular_functiondisordered domain specific binding
C0140296molecular_functiongeneral transcription initiation factor binding
C0140677molecular_functionmolecular function activator activity
C0140693molecular_functionmolecular condensate scaffold activity
C1900119biological_processpositive regulation of execution phase of apoptosis
C1901525biological_processnegative regulation of mitophagy
C1902108biological_processregulation of mitochondrial membrane permeability involved in apoptotic process
C1902253biological_processregulation of intrinsic apoptotic signaling pathway by p53 class mediator
C1902749biological_processregulation of cell cycle G2/M phase transition
C1902895biological_processpositive regulation of miRNA transcription
C1903451biological_processnegative regulation of G1 to G0 transition
C1903799biological_processnegative regulation of miRNA processing
C1904024biological_processnegative regulation of glucose catabolic process to lactate via pyruvate
C1905856biological_processnegative regulation of pentose-phosphate shunt
C1990144biological_processintrinsic apoptotic signaling pathway in response to hypoxia
C1990841molecular_functionpromoter-specific chromatin binding
C2000269biological_processregulation of fibroblast apoptotic process
C2000378biological_processnegative regulation of reactive oxygen species metabolic process
C2000379biological_processpositive regulation of reactive oxygen species metabolic process
C2000647biological_processnegative regulation of stem cell proliferation
C2000772biological_processregulation of cellular senescence
C2000774biological_processpositive regulation of cellular senescence
C2001244biological_processpositive regulation of intrinsic apoptotic signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00348
Number of Residues13
DetailsP53 p53 family signature. MCNSSCMGGMNRR
ChainResidueDetails
CMET237-ARG249

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues190
DetailsDNA_BIND: DNA_BIND => ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:18996393, ECO:0000269|PubMed:20364130
ChainResidueDetails
CTHR102-LYS292

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:14534297, ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:17015838, ECO:0000269|PubMed:18650397, ECO:0000269|PubMed:19515728, ECO:0000269|PubMed:20142040, ECO:0000269|PubMed:20364130
ChainResidueDetails
CCYS176
CHIS179
CCYS238
CCYS242

site_idSWS_FT_FI3
Number of Residues1
DetailsSITE: Interaction with DNA => ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:18996393, ECO:0000269|PubMed:20364130
ChainResidueDetails
CLYS120

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine; by HIPK4 => ECO:0000269|PubMed:18022393
ChainResidueDetails
CSER9
BCYS110-CYS146

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CDK5, PRPK, AMPK, NUAK1 and ATM => ECO:0000269|PubMed:10570149, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17108107, ECO:0000269|PubMed:17591690, ECO:0000269|PubMed:17967874, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:28842590
ChainResidueDetails
CSER15

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by CK1, VRK1 and VRK2 => ECO:0000269|PubMed:10606744, ECO:0000269|PubMed:10951572, ECO:0000269|PubMed:16704422, ECO:0000269|PubMed:31527692
ChainResidueDetails
CTHR18

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CHEK2, CK1 and PLK3 => ECO:0000269|PubMed:10570149, ECO:0000269|PubMed:11447225, ECO:0000269|PubMed:11551930, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:20041275
ChainResidueDetails
CSER20

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CDK5 and CDK7 => ECO:0000269|PubMed:17591690, ECO:0000269|PubMed:9372954
ChainResidueDetails
CSER33

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphoserine; by MAPKAPK5 => ECO:0000269|PubMed:17254968
ChainResidueDetails
CSER37

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CDK5, DYRK2, HIPK2 and PKC/PRKCG => ECO:0000269|PubMed:11740489, ECO:0000269|PubMed:11780126, ECO:0000269|PubMed:16377624, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:17591690
ChainResidueDetails
CSER46

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by TAF1 and GRK5 => ECO:0000269|PubMed:15053879, ECO:0000269|PubMed:20124405
ChainResidueDetails
CTHR55

site_idSWS_FT_FI12
Number of Residues2
DetailsMOD_RES: N6-lactoyllysine => ECO:0000269|PubMed:38653238
ChainResidueDetails
CLYS120
CLYS139

site_idSWS_FT_FI13
Number of Residues2
DetailsMOD_RES: Phosphoserine; by AURKB => ECO:0000269|PubMed:20959462
ChainResidueDetails
CSER183
CSER269

site_idSWS_FT_FI14
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by AURKB => ECO:0000269|PubMed:20959462
ChainResidueDetails
CTHR284

site_idSWS_FT_FI15
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:12724314
ChainResidueDetails
CLYS305

site_idSWS_FT_FI16
Number of Residues1
DetailsMOD_RES: Phosphoserine; by AURKA, CDK1 and CDK2 => ECO:0000269|PubMed:10884347, ECO:0000269|PubMed:14702041
ChainResidueDetails
CSER315

site_idSWS_FT_FI17
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P02340
ChainResidueDetails
CLYS321

site_idSWS_FT_FI18
Number of Residues1
DetailsMOD_RES: Omega-N-methylarginine; by PRMT5 => ECO:0000269|PubMed:19011621
ChainResidueDetails
CARG333

site_idSWS_FT_FI19
Number of Residues2
DetailsMOD_RES: Symmetric dimethylarginine; by PRMT5 => ECO:0000269|PubMed:19011621
ChainResidueDetails
CARG335
CARG337

site_idSWS_FT_FI20
Number of Residues1
DetailsMOD_RES: N6-methyllysine; by SMYD2; alternate => ECO:0000269|PubMed:17108971, ECO:0000269|PubMed:22864287
ChainResidueDetails
CLYS370

site_idSWS_FT_FI21
Number of Residues1
DetailsMOD_RES: N6-methyllysine; by SETD7 => ECO:0000269|PubMed:15525938, ECO:0000269|PubMed:16415881
ChainResidueDetails
CLYS372

site_idSWS_FT_FI22
Number of Residues1
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:10656795
ChainResidueDetails
CLYS373

site_idSWS_FT_FI23
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:29474172, ECO:0007744|PubMed:19608861
ChainResidueDetails
CLYS381

site_idSWS_FT_FI24
Number of Residues1
DetailsMOD_RES: N6-methyllysine; by KMT5A; alternate => ECO:0000269|PubMed:17707234, ECO:0000269|PubMed:20870725, ECO:0000269|PubMed:22864287
ChainResidueDetails
CLYS382

site_idSWS_FT_FI25
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CK2, CDK2 and NUAK1 => ECO:0000269|PubMed:10884347, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:17108107, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:22214662, ECO:0000269|PubMed:35618207
ChainResidueDetails
CSER392

site_idSWS_FT_FI26
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:21597459
ChainResidueDetails
CLYS24

site_idSWS_FT_FI27
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:11124955, ECO:0000269|PubMed:22214662, ECO:0000269|Ref.37
ChainResidueDetails
CLYS386

site_idSWS_FT_FI28
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19536131
ChainResidueDetails
CLYS291
CLYS292

site_idSWS_FT_FI29
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19033443
ChainResidueDetails
CLYS351
CLYS357

Catalytic Information from CSA
site_idMCSA1
Number of Residues6
DetailsM-CSA 438
ChainResidueDetails
AARG529unknown
AGLU562unknown
AGLU573unknown
AASP630electrostatic stabiliser
AHIS841
ACYS843covalent catalysis

227344

PDB entries from 2024-11-13

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