8QZ3
Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with an activatory nanobody (Nb67)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005267 | molecular_function | potassium channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 0005267 | molecular_function | potassium channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0071805 | biological_process | potassium ion transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 52 |
| Details | INTRAMEM: Pore-forming; Name=Pore-forming 1 => ECO:0007744|PDB:4BW5 |
| Chain | Residue | Details |
| A | SER154-PRO180 | |
| B | SER154-PRO180 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 120 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | THR182-PHE202 | |
| A | THR234-THR254 | |
| A | GLU299-VAL319 | |
| B | THR182-PHE202 | |
| B | THR234-THR254 | |
| B | GLU299-VAL319 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 60 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU203-GLN233 | |
| B | LEU203-GLN233 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 62 |
| Details | INTRAMEM: Pore-forming; Name=Pore-forming 2 => ECO:0007744|PDB:4BW5 |
| Chain | Residue | Details |
| A | ILE263-GLY294 | |
| B | ILE263-GLY294 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25766236, ECO:0007744|PDB:4XDK |
| Chain | Residue | Details |
| A | GLY167 | |
| B | THR168 | |
| B | VAL169 | |
| B | ILE170 | |
| B | VAL276 | |
| B | VAL277 | |
| B | THR278 | |
| B | LEU279 | |
| A | THR168 | |
| A | VAL169 | |
| A | ILE170 | |
| A | VAL276 | |
| A | VAL277 | |
| A | THR278 | |
| A | LEU279 | |
| B | GLY167 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: pH sensor => ECO:0000250|UniProtKB:Q8BUW1 |
| Chain | Residue | Details |
| A | SER151 | |
| B | SER151 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL144 | |
| A | ILE147 | |
| A | GLY148 | |
| B | VAL144 | |
| B | ILE147 | |
| B | GLY148 |
