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8Q4L

GBP1 bound by 14-3-3sigma

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0001530molecular_functionlipopolysaccharide binding
A0003779molecular_functionactin binding
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0004382molecular_functionGDP phosphatase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005576cellular_componentextracellular region
A0005737cellular_componentcytoplasm
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0012506cellular_componentvesicle membrane
A0015629cellular_componentactin cytoskeleton
A0016787molecular_functionhydrolase activity
A0019003molecular_functionGDP binding
A0019899molecular_functionenzyme binding
A0019955molecular_functioncytokine binding
A0030507molecular_functionspectrin binding
A0030659cellular_componentcytoplasmic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0032703biological_processnegative regulation of interleukin-2 production
A0042742biological_processdefense response to bacterium
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0042832biological_processdefense response to protozoan
A0045087biological_processinnate immune response
A0050848biological_processregulation of calcium-mediated signaling
A0050860biological_processnegative regulation of T cell receptor signaling pathway
A0051607biological_processdefense response to virus
A0051715biological_processcytolysis in another organism
A0051879molecular_functionHsp90 protein binding
A0070373biological_processnegative regulation of ERK1 and ERK2 cascade
A0071346biological_processcellular response to type II interferon
A0071347biological_processcellular response to interleukin-1
A0071356biological_processcellular response to tumor necrosis factor
A0072665biological_processprotein localization to vacuole
A0106139cellular_componentsymbiont cell surface
A0140639biological_processpositive regulation of pyroptotic inflammatory response
A0160075biological_processnon-canonical inflammasome complex assembly
A1900025biological_processnegative regulation of substrate adhesion-dependent cell spreading
A1903076biological_processregulation of protein localization to plasma membrane
A1903077biological_processnegative regulation of protein localization to plasma membrane
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0001836biological_processrelease of cytochrome c from mitochondria
B0003334biological_processkeratinocyte development
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006469biological_processnegative regulation of protein kinase activity
B0006611biological_processprotein export from nucleus
B0007165biological_processsignal transduction
B0008104biological_processprotein localization
B0008426molecular_functionprotein kinase C inhibitor activity
B0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
B0010482biological_processregulation of epidermal cell division
B0010737biological_processprotein kinase A signaling
B0010839biological_processnegative regulation of keratinocyte proliferation
B0019901molecular_functionprotein kinase binding
B0030216biological_processkeratinocyte differentiation
B0030307biological_processpositive regulation of cell growth
B0031424biological_processkeratinization
B0042802molecular_functionidentical protein binding
B0043588biological_processskin development
B0043616biological_processkeratinocyte proliferation
B0045296molecular_functioncadherin binding
B0045606biological_processpositive regulation of epidermal cell differentiation
B0045785biological_processpositive regulation of cell adhesion
B0045824biological_processnegative regulation of innate immune response
B0046827biological_processpositive regulation of protein export from nucleus
B0050815molecular_functionphosphoserine residue binding
B0051219molecular_functionphosphoprotein binding
B0051726biological_processregulation of cell cycle
B0061436biological_processestablishment of skin barrier
B0070062cellular_componentextracellular exosome
B0072089biological_processstem cell proliferation
B0140311molecular_functionprotein sequestering activity
B1903077biological_processnegative regulation of protein localization to plasma membrane
B1903829biological_processpositive regulation of protein localization
B2000647biological_processnegative regulation of stem cell proliferation
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0001836biological_processrelease of cytochrome c from mitochondria
C0003334biological_processkeratinocyte development
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006469biological_processnegative regulation of protein kinase activity
C0006611biological_processprotein export from nucleus
C0007165biological_processsignal transduction
C0008104biological_processprotein localization
C0008426molecular_functionprotein kinase C inhibitor activity
C0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
C0010482biological_processregulation of epidermal cell division
C0010737biological_processprotein kinase A signaling
C0010839biological_processnegative regulation of keratinocyte proliferation
C0019901molecular_functionprotein kinase binding
C0030216biological_processkeratinocyte differentiation
C0030307biological_processpositive regulation of cell growth
C0031424biological_processkeratinization
C0042802molecular_functionidentical protein binding
C0043588biological_processskin development
C0043616biological_processkeratinocyte proliferation
C0045296molecular_functioncadherin binding
C0045606biological_processpositive regulation of epidermal cell differentiation
C0045785biological_processpositive regulation of cell adhesion
C0045824biological_processnegative regulation of innate immune response
C0046827biological_processpositive regulation of protein export from nucleus
C0050815molecular_functionphosphoserine residue binding
C0051219molecular_functionphosphoprotein binding
C0051726biological_processregulation of cell cycle
C0061436biological_processestablishment of skin barrier
C0070062cellular_componentextracellular exosome
C0072089biological_processstem cell proliferation
C0140311molecular_functionprotein sequestering activity
C1903077biological_processnegative regulation of protein localization to plasma membrane
C1903829biological_processpositive regulation of protein localization
C2000647biological_processnegative regulation of stem cell proliferation
Functional Information from PROSITE/UniProt
site_idPS00796
Number of Residues11
Details1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV
ChainResidueDetails
BARG41-VAL51

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsSITE: Interaction with phosphoserine on interacting protein
ChainResidueDetails
BARG56
BARG129
CARG56
CARG129

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
BSER5
CSER5

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER74
CSER74

site_idSWS_FT_FI4
Number of Residues8
DetailsCROSSLNK: (Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:29144452
ChainResidueDetails
ALYS207
ALYS209
ALYS210
ALYS382
ALYS562
ALYS567
ALYS573

221716

PDB entries from 2024-06-26

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