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8Q4L

GBP1 bound by 14-3-3sigma

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0000166molecular_functionnucleotide binding
A0001530molecular_functionlipopolysaccharide binding
A0002376biological_processimmune system process
A0003779molecular_functionactin binding
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0004382molecular_functionGDP phosphatase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005576cellular_componentextracellular region
A0005737cellular_componentcytoplasm
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0012506cellular_componentvesicle membrane
A0015629cellular_componentactin cytoskeleton
A0016787molecular_functionhydrolase activity
A0019003molecular_functionGDP binding
A0019899molecular_functionenzyme binding
A0019955molecular_functioncytokine binding
A0030507molecular_functionspectrin binding
A0030659cellular_componentcytoplasmic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0032703biological_processnegative regulation of interleukin-2 production
A0042742biological_processdefense response to bacterium
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0042832biological_processdefense response to protozoan
A0045087biological_processinnate immune response
A0050848biological_processregulation of calcium-mediated signaling
A0050860biological_processnegative regulation of T cell receptor signaling pathway
A0051607biological_processdefense response to virus
A0051715biological_processcytolysis in another organism
A0051879molecular_functionHsp90 protein binding
A0070373biological_processnegative regulation of ERK1 and ERK2 cascade
A0071346biological_processcellular response to type II interferon
A0071347biological_processcellular response to interleukin-1
A0071356biological_processcellular response to tumor necrosis factor
A0072665biological_processprotein localization to vacuole
A0106139cellular_componentsymbiont cell surface
A0140639biological_processpositive regulation of pyroptotic inflammatory response
A0160075biological_processnon-canonical inflammasome complex assembly
A1900025biological_processnegative regulation of substrate adhesion-dependent cell spreading
A1903076biological_processregulation of protein localization to plasma membrane
A1903077biological_processnegative regulation of protein localization to plasma membrane
B0001836biological_processrelease of cytochrome c from mitochondria
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006469biological_processnegative regulation of protein kinase activity
B0006611biological_processprotein export from nucleus
B0007165biological_processsignal transduction
B0008104biological_processintracellular protein localization
B0008426molecular_functionprotein kinase C inhibitor activity
B0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
B0010482biological_processregulation of epidermal cell division
B0019901molecular_functionprotein kinase binding
B0022407biological_processregulation of cell-cell adhesion
B0030307biological_processpositive regulation of cell growth
B0032880biological_processregulation of protein localization
B0042802molecular_functionidentical protein binding
B0045296molecular_functioncadherin binding
B0045606biological_processpositive regulation of epidermal cell differentiation
B0045785biological_processpositive regulation of cell adhesion
B0045824biological_processnegative regulation of innate immune response
B0046827biological_processpositive regulation of protein export from nucleus
B0050815molecular_functionphosphoserine residue binding
B0051219molecular_functionphosphoprotein binding
B0061436biological_processestablishment of skin barrier
B0070062cellular_componentextracellular exosome
B0140311molecular_functionprotein sequestering activity
B0141156biological_processcAMP/PKA signal transduction
B1903077biological_processnegative regulation of protein localization to plasma membrane
B1903829biological_processpositive regulation of protein localization
C0001836biological_processrelease of cytochrome c from mitochondria
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006469biological_processnegative regulation of protein kinase activity
C0006611biological_processprotein export from nucleus
C0007165biological_processsignal transduction
C0008104biological_processintracellular protein localization
C0008426molecular_functionprotein kinase C inhibitor activity
C0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
C0010482biological_processregulation of epidermal cell division
C0019901molecular_functionprotein kinase binding
C0022407biological_processregulation of cell-cell adhesion
C0030307biological_processpositive regulation of cell growth
C0032880biological_processregulation of protein localization
C0042802molecular_functionidentical protein binding
C0045296molecular_functioncadherin binding
C0045606biological_processpositive regulation of epidermal cell differentiation
C0045785biological_processpositive regulation of cell adhesion
C0045824biological_processnegative regulation of innate immune response
C0046827biological_processpositive regulation of protein export from nucleus
C0050815molecular_functionphosphoserine residue binding
C0051219molecular_functionphosphoprotein binding
C0061436biological_processestablishment of skin barrier
C0070062cellular_componentextracellular exosome
C0140311molecular_functionprotein sequestering activity
C0141156biological_processcAMP/PKA signal transduction
C1903077biological_processnegative regulation of protein localization to plasma membrane
C1903829biological_processpositive regulation of protein localization
Functional Information from PROSITE/UniProt
site_idPS00796
Number of Residues11
Details1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV
ChainResidueDetails
BARG41-VAL51

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"10676968","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10970849","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16511497","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1F5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2B8W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2B92","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2D4H","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by PIM1","evidences":[{"source":"PubMed","id":"37797010","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues8
DetailsCross-link: {"description":"(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"29144452","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues4
DetailsSite: {"description":"Interaction with phosphoserine on interacting protein"}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

247947

PDB entries from 2026-01-21

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