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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8PYI

Human IGF1R with inhibitor 6

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
AAA0004672molecular_functionprotein kinase activity
AAA0004713molecular_functionprotein tyrosine kinase activity
AAA0004714molecular_functiontransmembrane receptor protein tyrosine kinase activity
AAA0005524molecular_functionATP binding
AAA0006468biological_processprotein phosphorylation
AAA0007169biological_processcell surface receptor protein tyrosine kinase signaling pathway
AAA0016020cellular_componentmembrane
BBB0004672molecular_functionprotein kinase activity
BBB0004713molecular_functionprotein tyrosine kinase activity
BBB0004714molecular_functiontransmembrane receptor protein tyrosine kinase activity
BBB0005524molecular_functionATP binding
BBB0006468biological_processprotein phosphorylation
BBB0007169biological_processcell surface receptor protein tyrosine kinase signaling pathway
BBB0016020cellular_componentmembrane
CCC0004672molecular_functionprotein kinase activity
CCC0004713molecular_functionprotein tyrosine kinase activity
CCC0004714molecular_functiontransmembrane receptor protein tyrosine kinase activity
CCC0005524molecular_functionATP binding
CCC0006468biological_processprotein phosphorylation
CCC0007169biological_processcell surface receptor protein tyrosine kinase signaling pathway
CCC0016020cellular_componentmembrane
DDD0004672molecular_functionprotein kinase activity
DDD0004713molecular_functionprotein tyrosine kinase activity
DDD0004714molecular_functiontransmembrane receptor protein tyrosine kinase activity
DDD0005524molecular_functionATP binding
DDD0006468biological_processprotein phosphorylation
DDD0007169biological_processcell surface receptor protein tyrosine kinase signaling pathway
DDD0016020cellular_componentmembrane
EEE0004672molecular_functionprotein kinase activity
EEE0004713molecular_functionprotein tyrosine kinase activity
EEE0004714molecular_functiontransmembrane receptor protein tyrosine kinase activity
EEE0005524molecular_functionATP binding
EEE0006468biological_processprotein phosphorylation
EEE0007169biological_processcell surface receptor protein tyrosine kinase signaling pathway
EEE0016020cellular_componentmembrane
FFF0004672molecular_functionprotein kinase activity
FFF0004713molecular_functionprotein tyrosine kinase activity
FFF0004714molecular_functiontransmembrane receptor protein tyrosine kinase activity
FFF0005524molecular_functionATP binding
FFF0006468biological_processprotein phosphorylation
FFF0007169biological_processcell surface receptor protein tyrosine kinase signaling pathway
FFF0016020cellular_componentmembrane
GGG0004672molecular_functionprotein kinase activity
GGG0004713molecular_functionprotein tyrosine kinase activity
GGG0004714molecular_functiontransmembrane receptor protein tyrosine kinase activity
GGG0005524molecular_functionATP binding
GGG0006468biological_processprotein phosphorylation
GGG0007169biological_processcell surface receptor protein tyrosine kinase signaling pathway
GGG0016020cellular_componentmembrane
HHH0004672molecular_functionprotein kinase activity
HHH0004713molecular_functionprotein tyrosine kinase activity
HHH0004714molecular_functiontransmembrane receptor protein tyrosine kinase activity
HHH0005524molecular_functionATP binding
HHH0006468biological_processprotein phosphorylation
HHH0007169biological_processcell surface receptor protein tyrosine kinase signaling pathway
HHH0016020cellular_componentmembrane
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues29
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGSFGMVYeGvakgvvkdepetr.....VAIK
ChainResidueDetails
AAALEU1005-LYS1033
site_idPS00109
Number of Residues13
DetailsPROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLAARNCMV
ChainResidueDetails
AAAPHE1131-VAL1143
site_idPS00239
Number of Residues9
DetailsRECEPTOR_TYR_KIN_II Receptor tyrosine kinase class II signature. DIYetdYYR
ChainResidueDetails
AAAASP1159-ARG1167
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues64
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues8
DetailsBinding site: {}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues16
DetailsModified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"11694888","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18501599","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19041240","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26584640","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues8
DetailsModified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"11694888","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18501599","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19041240","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues8
DetailsModified residue: {"description":"Phosphoserine; by GSK3-beta","evidences":[{"source":"UniProtKB","id":"Q60751","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues8
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q60751","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"21994939","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246031

PDB entries from 2025-12-10

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