8PVB
Structure of GABAAR determined by cryoEM at 100 keV
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0004890 | molecular_function | GABA-A receptor activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
Functional Information from PROSITE/UniProt
| site_id | PS00236 |
| Number of Residues | 15 |
| Details | NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CmMdLrrYPlDeqnC |
| Chain | Residue | Details |
| A | CYS136-CYS150 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 231 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:24909990 |
| Chain | Residue | Details |
| A | GLN1-PHE221 | |
| A | LEU268-THR279 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 63 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:35355020, ECO:0007744|PDB:7QN7 |
| Chain | Residue | Details |
| A | ILE222-ILE242 | |
| A | SER247-HIS267 | |
| A | ALA280-ASN303 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:24909990 |
| Chain | Residue | Details |
| A | ASN243-ALA246 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24909990 |
| Chain | Residue | Details |
| A | ASP95 | |
| A | PHE200 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | BINDING: in chain B => ECO:0000269|PubMed:35355020, ECO:0007744|PDB:7QN7 |
| Chain | Residue | Details |
| A | TYR97 | |
| A | SER156 | |
| A | THR202 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | BINDING: in chain A => ECO:0000269|PubMed:35355020, ECO:0007744|PDB:7QN7 |
| Chain | Residue | Details |
| A | GLU155 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | BINDING: in chain A => ECO:0000269|PubMed:30140029, ECO:0007744|PDB:6A96 |
| Chain | Residue | Details |
| A | TYR157 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24909990, ECO:0000269|PubMed:35355020, ECO:0007744|PDB:7QN7 |
| Chain | Residue | Details |
| A | ASN8 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24909990, ECO:0000269|PubMed:30602789, ECO:0000269|PubMed:35355020, ECO:0007744|PDB:6I53, ECO:0007744|PDB:7QN7 |
| Chain | Residue | Details |
| A | ASN80 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24909990, ECO:0000269|PubMed:30140029, ECO:0000269|PubMed:30602789, ECO:0000269|PubMed:35355020, ECO:0007744|PDB:6A96, ECO:0007744|PDB:6I53, ECO:0007744|PDB:7QN7 |
| Chain | Residue | Details |
| A | ASN149 |
