8PTY
Cryo-EM structure of human Elp123 in complex with 5'-deoxyadenosine and methionine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0002098 | biological_process | tRNA wobble uridine modification |
| A | 0002926 | biological_process | tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006417 | biological_process | regulation of translation |
| A | 0008033 | biological_process | tRNA processing |
| A | 0033588 | cellular_component | elongator holoenzyme complex |
| B | 0000993 | molecular_function | RNA polymerase II complex binding |
| B | 0002098 | biological_process | tRNA wobble uridine modification |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| B | 0006368 | biological_process | transcription elongation by RNA polymerase II |
| B | 0006417 | biological_process | regulation of translation |
| B | 0008023 | cellular_component | transcription elongation factor complex |
| B | 0008033 | biological_process | tRNA processing |
| B | 0019901 | molecular_function | protein kinase binding |
| B | 0033588 | cellular_component | elongator holoenzyme complex |
| C | 0000049 | molecular_function | tRNA binding |
| C | 0001764 | biological_process | neuron migration |
| C | 0002098 | biological_process | tRNA wobble uridine modification |
| C | 0002926 | biological_process | tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation |
| C | 0003723 | molecular_function | RNA binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005730 | cellular_component | nucleolus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| C | 0006417 | biological_process | regulation of translation |
| C | 0007399 | biological_process | nervous system development |
| C | 0007417 | biological_process | central nervous system development |
| C | 0008033 | biological_process | tRNA processing |
| C | 0016407 | molecular_function | acetyltransferase activity |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016746 | molecular_function | acyltransferase activity |
| C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| C | 0030335 | biological_process | positive regulation of cell migration |
| C | 0033588 | cellular_component | elongator holoenzyme complex |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0051536 | molecular_function | iron-sulfur cluster binding |
| C | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| C | 0106261 | molecular_function | tRNA uridine(34) acetyltransferase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"WD 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 44 |
| Details | Repeat: {"description":"WD 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 47 |
| Details | Repeat: {"description":"WD 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"WD 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 48 |
| Details | Repeat: {"description":"WD 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"WD 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"WD 8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"WD 9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 44 |
| Details | Repeat: {"description":"WD 10"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"WD 12"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"WD 13"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q02908","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"A0A1C7D1B7","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9CZX0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by ALK","evidences":[{"source":"PubMed","id":"31341009","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"31341009","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
