8PMQ

Catalytic module of yeast GID E3 ligase bound to multiphosphorylated Ubc8~ubiquitin

Functional Information from GO Data

Chain	GOid	namespace	contents
2	0004842	molecular_function	ubiquitin-protein transferase activity
2	0005515	molecular_function	protein binding
2	0005634	cellular_component	nucleus
2	0005737	cellular_component	cytoplasm
2	0005777	cellular_component	peroxisome
2	0005829	cellular_component	cytosol
2	0006511	biological_process	ubiquitin-dependent protein catabolic process
2	0008270	molecular_function	zinc ion binding
2	0016567	biological_process	protein ubiquitination
2	0016740	molecular_function	transferase activity
2	0034657	cellular_component	GID complex
2	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
2	0045721	biological_process	negative regulation of gluconeogenesis
2	0046872	molecular_function	metal ion binding
2	0061630	molecular_function	ubiquitin protein ligase activity
9	0004842	molecular_function	ubiquitin-protein transferase activity
9	0005515	molecular_function	protein binding
9	0005634	cellular_component	nucleus
9	0005737	cellular_component	cytoplasm
9	0008270	molecular_function	zinc ion binding
9	0016567	biological_process	protein ubiquitination
9	0016740	molecular_function	transferase activity
9	0034657	cellular_component	GID complex
9	0043066	biological_process	negative regulation of apoptotic process
9	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
9	0045721	biological_process	negative regulation of gluconeogenesis
9	0046872	molecular_function	metal ion binding
9	0061630	molecular_function	ubiquitin protein ligase activity
E	0000166	molecular_function	nucleotide binding
E	0000209	biological_process	protein polyubiquitination
E	0004842	molecular_function	ubiquitin-protein transferase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0016567	biological_process	protein ubiquitination
E	0016740	molecular_function	transferase activity
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0045721	biological_process	negative regulation of gluconeogenesis
E	0061631	molecular_function	ubiquitin conjugating enzyme activity
E	0070096	biological_process	mitochondrial outer membrane translocase complex assembly

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
U	LYS27-ASP52

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	110
Details	Zinc finger: {"description":"RING-Gid-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01215","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	58
Details	Domain: {"description":"CTLH","evidences":[{"source":"PROSITE-ProRule","id":"PRU00058","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Essential for ubiquitin ligase activity","evidences":[{"source":"PubMed","id":"22044534","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10133","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	75
Details	Domain: {"description":"Ubiquitin-like 9","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---