Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

8PKP

Cryo-EM structure of the apo Anaphase-promoting complex/cyclosome (APC/C) at 3.2 Angstrom resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005680cellular_componentanaphase-promoting complex
A0005829cellular_componentcytosol
A0007091biological_processmetaphase/anaphase transition of mitotic cell cycle
A0007346biological_processregulation of mitotic cell cycle
A0016567biological_processprotein ubiquitination
A0031145biological_processanaphase-promoting complex-dependent catabolic process
A0051301biological_processcell division
A0051445biological_processregulation of meiotic cell cycle
A0060090molecular_functionmolecular adaptor activity
A0070936biological_processprotein K48-linked ubiquitination
A0070979biological_processprotein K11-linked ubiquitination
A0141198biological_processprotein branched polyubiquitination
C0000278biological_processmitotic cell cycle
C0004842molecular_functionubiquitin-protein transferase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005680cellular_componentanaphase-promoting complex
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006511biological_processubiquitin-dependent protein catabolic process
C0007346biological_processregulation of mitotic cell cycle
C0008270molecular_functionzinc ion binding
C0016567biological_processprotein ubiquitination
C0031145biological_processanaphase-promoting complex-dependent catabolic process
C0034450molecular_functionubiquitin-ubiquitin ligase activity
C0045842biological_processpositive regulation of mitotic metaphase/anaphase transition
C0046872molecular_functionmetal ion binding
C0051301biological_processcell division
C0051445biological_processregulation of meiotic cell cycle
C0061630molecular_functionubiquitin protein ligase activity
C0070936biological_processprotein K48-linked ubiquitination
C0070979biological_processprotein K11-linked ubiquitination
C0097602molecular_functioncullin family protein binding
C0141198biological_processprotein branched polyubiquitination
D0005515molecular_functionprotein binding
D0005654cellular_componentnucleoplasm
D0005680cellular_componentanaphase-promoting complex
D0005829cellular_componentcytosol
D0007346biological_processregulation of mitotic cell cycle
D0031145biological_processanaphase-promoting complex-dependent catabolic process
D0051301biological_processcell division
D0051445biological_processregulation of meiotic cell cycle
D0070936biological_processprotein K48-linked ubiquitination
D0070979biological_processprotein K11-linked ubiquitination
D0090266biological_processregulation of mitotic cell cycle spindle assembly checkpoint
D0141198biological_processprotein branched polyubiquitination
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005680cellular_componentanaphase-promoting complex
G0005829cellular_componentcytosol
G0007346biological_processregulation of mitotic cell cycle
G0016567biological_processprotein ubiquitination
G0031145biological_processanaphase-promoting complex-dependent catabolic process
G0051301biological_processcell division
G0051445biological_processregulation of meiotic cell cycle
G0070936biological_processprotein K48-linked ubiquitination
G0070979biological_processprotein K11-linked ubiquitination
G0141198biological_processprotein branched polyubiquitination
H0000775cellular_componentchromosome, centromeric region
H0000776cellular_componentkinetochore
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005680cellular_componentanaphase-promoting complex
H0005694cellular_componentchromosome
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0007346biological_processregulation of mitotic cell cycle
H0016567biological_processprotein ubiquitination
H0031145biological_processanaphase-promoting complex-dependent catabolic process
H0051301biological_processcell division
H0051445biological_processregulation of meiotic cell cycle
H0070936biological_processprotein K48-linked ubiquitination
H0070979biological_processprotein K11-linked ubiquitination
H0141198biological_processprotein branched polyubiquitination
I0004842molecular_functionubiquitin-protein transferase activity
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005680cellular_componentanaphase-promoting complex
I0005829cellular_componentcytosol
I0007346biological_processregulation of mitotic cell cycle
I0016567biological_processprotein ubiquitination
I0019903molecular_functionprotein phosphatase binding
I0030071biological_processregulation of mitotic metaphase/anaphase transition
I0031145biological_processanaphase-promoting complex-dependent catabolic process
I0034399cellular_componentnuclear periphery
I0051301biological_processcell division
I0051445biological_processregulation of meiotic cell cycle
I0070936biological_processprotein K48-linked ubiquitination
I0070979biological_processprotein K11-linked ubiquitination
I0141198biological_processprotein branched polyubiquitination
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005680cellular_componentanaphase-promoting complex
J0005737cellular_componentcytoplasm
J0005813cellular_componentcentrosome
J0005819cellular_componentspindle
J0005829cellular_componentcytosol
J0005856cellular_componentcytoskeleton
J0007091biological_processmetaphase/anaphase transition of mitotic cell cycle
J0007346biological_processregulation of mitotic cell cycle
J0016567biological_processprotein ubiquitination
J0019903molecular_functionprotein phosphatase binding
J0031145biological_processanaphase-promoting complex-dependent catabolic process
J0051301biological_processcell division
J0051445biological_processregulation of meiotic cell cycle
J0070936biological_processprotein K48-linked ubiquitination
J0070979biological_processprotein K11-linked ubiquitination
J0072686cellular_componentmitotic spindle
J0141198biological_processprotein branched polyubiquitination
K0005515molecular_functionprotein binding
K0005634cellular_componentnucleus
K0005654cellular_componentnucleoplasm
K0005680cellular_componentanaphase-promoting complex
K0005737cellular_componentcytoplasm
K0005813cellular_componentcentrosome
K0005819cellular_componentspindle
K0005829cellular_componentcytosol
K0005856cellular_componentcytoskeleton
K0007346biological_processregulation of mitotic cell cycle
K0016567biological_processprotein ubiquitination
K0031145biological_processanaphase-promoting complex-dependent catabolic process
K0045842biological_processpositive regulation of mitotic metaphase/anaphase transition
K0051301biological_processcell division
K0051445biological_processregulation of meiotic cell cycle
K0070936biological_processprotein K48-linked ubiquitination
K0070979biological_processprotein K11-linked ubiquitination
K0072686cellular_componentmitotic spindle
K0141198biological_processprotein branched polyubiquitination
L0005515molecular_functionprotein binding
L0005654cellular_componentnucleoplasm
L0005680cellular_componentanaphase-promoting complex
L0005737cellular_componentcytoplasm
L0005829cellular_componentcytosol
L0007346biological_processregulation of mitotic cell cycle
L0016567biological_processprotein ubiquitination
L0031145biological_processanaphase-promoting complex-dependent catabolic process
L0051301biological_processcell division
L0051445biological_processregulation of meiotic cell cycle
L0070936biological_processprotein K48-linked ubiquitination
L0070979biological_processprotein K11-linked ubiquitination
L0141198biological_processprotein branched polyubiquitination
M0005515molecular_functionprotein binding
M0005634cellular_componentnucleus
M0005680cellular_componentanaphase-promoting complex
M0007346biological_processregulation of mitotic cell cycle
M0016567biological_processprotein ubiquitination
M0031145biological_processanaphase-promoting complex-dependent catabolic process
M0051301biological_processcell division
M0051445biological_processregulation of meiotic cell cycle
M0070936biological_processprotein K48-linked ubiquitination
M0070979biological_processprotein K11-linked ubiquitination
M0141198biological_processprotein branched polyubiquitination
N0005515molecular_functionprotein binding
N0005654cellular_componentnucleoplasm
N0005680cellular_componentanaphase-promoting complex
N0005829cellular_componentcytosol
N0006511biological_processubiquitin-dependent protein catabolic process
N0007091biological_processmetaphase/anaphase transition of mitotic cell cycle
N0007346biological_processregulation of mitotic cell cycle
N0007399biological_processnervous system development
N0010629biological_processnegative regulation of gene expression
N0016567biological_processprotein ubiquitination
N0030154biological_processcell differentiation
N0031145biological_processanaphase-promoting complex-dependent catabolic process
N0031461cellular_componentcullin-RING ubiquitin ligase complex
N0031625molecular_functionubiquitin protein ligase binding
N0031915biological_processpositive regulation of synaptic plasticity
N0045773biological_processpositive regulation of axon extension
N0050775biological_processpositive regulation of dendrite morphogenesis
N0051301biological_processcell division
N0051445biological_processregulation of meiotic cell cycle
N0070936biological_processprotein K48-linked ubiquitination
N0070979biological_processprotein K11-linked ubiquitination
N0090129biological_processpositive regulation of synapse maturation
N0141198biological_processprotein branched polyubiquitination
O0005634cellular_componentnucleus
O0005654cellular_componentnucleoplasm
O0005680cellular_componentanaphase-promoting complex
O0005737cellular_componentcytoplasm
O0005819cellular_componentspindle
O0005829cellular_componentcytosol
O0005856cellular_componentcytoskeleton
O0007346biological_processregulation of mitotic cell cycle
O0016567biological_processprotein ubiquitination
O0019903molecular_functionprotein phosphatase binding
O0031145biological_processanaphase-promoting complex-dependent catabolic process
O0045842biological_processpositive regulation of mitotic metaphase/anaphase transition
O0051301biological_processcell division
O0051445biological_processregulation of meiotic cell cycle
O0070936biological_processprotein K48-linked ubiquitination
O0070979biological_processprotein K11-linked ubiquitination
O0141198biological_processprotein branched polyubiquitination
P0005515molecular_functionprotein binding
P0005634cellular_componentnucleus
P0005654cellular_componentnucleoplasm
P0005680cellular_componentanaphase-promoting complex
P0005737cellular_componentcytoplasm
P0005813cellular_componentcentrosome
P0005819cellular_componentspindle
P0005829cellular_componentcytosol
P0005856cellular_componentcytoskeleton
P0007091biological_processmetaphase/anaphase transition of mitotic cell cycle
P0007346biological_processregulation of mitotic cell cycle
P0016567biological_processprotein ubiquitination
P0019903molecular_functionprotein phosphatase binding
P0031145biological_processanaphase-promoting complex-dependent catabolic process
P0051301biological_processcell division
P0051445biological_processregulation of meiotic cell cycle
P0070936biological_processprotein K48-linked ubiquitination
P0070979biological_processprotein K11-linked ubiquitination
P0072686cellular_componentmitotic spindle
P0141198biological_processprotein branched polyubiquitination
Q0005515molecular_functionprotein binding
Q0005634cellular_componentnucleus
Q0005654cellular_componentnucleoplasm
Q0005680cellular_componentanaphase-promoting complex
Q0005737cellular_componentcytoplasm
Q0005813cellular_componentcentrosome
Q0005819cellular_componentspindle
Q0005829cellular_componentcytosol
Q0005856cellular_componentcytoskeleton
Q0007346biological_processregulation of mitotic cell cycle
Q0016567biological_processprotein ubiquitination
Q0031145biological_processanaphase-promoting complex-dependent catabolic process
Q0045842biological_processpositive regulation of mitotic metaphase/anaphase transition
Q0051301biological_processcell division
Q0051445biological_processregulation of meiotic cell cycle
Q0070936biological_processprotein K48-linked ubiquitination
Q0070979biological_processprotein K11-linked ubiquitination
Q0072686cellular_componentmitotic spindle
Q0141198biological_processprotein branched polyubiquitination
U0000278biological_processmitotic cell cycle
U0004842molecular_functionubiquitin-protein transferase activity
U0005515molecular_functionprotein binding
U0005654cellular_componentnucleoplasm
U0005680cellular_componentanaphase-promoting complex
U0005829cellular_componentcytosol
U0006511biological_processubiquitin-dependent protein catabolic process
U0007080biological_processmitotic metaphase chromosome alignment
U0007091biological_processmetaphase/anaphase transition of mitotic cell cycle
U0007096biological_processregulation of exit from mitosis
U0007346biological_processregulation of mitotic cell cycle
U0016567biological_processprotein ubiquitination
U0030071biological_processregulation of mitotic metaphase/anaphase transition
U0031145biological_processanaphase-promoting complex-dependent catabolic process
U0045842biological_processpositive regulation of mitotic metaphase/anaphase transition
U0051301biological_processcell division
U0051445biological_processregulation of meiotic cell cycle
U0070936biological_processprotein K48-linked ubiquitination
U0070979biological_processprotein K11-linked ubiquitination
U0141198biological_processprotein branched polyubiquitination
V0000278biological_processmitotic cell cycle
V0004842molecular_functionubiquitin-protein transferase activity
V0005515molecular_functionprotein binding
V0005654cellular_componentnucleoplasm
V0005680cellular_componentanaphase-promoting complex
V0005829cellular_componentcytosol
V0006511biological_processubiquitin-dependent protein catabolic process
V0007080biological_processmitotic metaphase chromosome alignment
V0007091biological_processmetaphase/anaphase transition of mitotic cell cycle
V0007096biological_processregulation of exit from mitosis
V0007346biological_processregulation of mitotic cell cycle
V0016567biological_processprotein ubiquitination
V0030071biological_processregulation of mitotic metaphase/anaphase transition
V0031145biological_processanaphase-promoting complex-dependent catabolic process
V0045842biological_processpositive regulation of mitotic metaphase/anaphase transition
V0051301biological_processcell division
V0051445biological_processregulation of meiotic cell cycle
V0070936biological_processprotein K48-linked ubiquitination
V0070979biological_processprotein K11-linked ubiquitination
V0141198biological_processprotein branched polyubiquitination
W0005515molecular_functionprotein binding
W0005634cellular_componentnucleus
W0005654cellular_componentnucleoplasm
W0005680cellular_componentanaphase-promoting complex
W0005829cellular_componentcytosol
W0007346biological_processregulation of mitotic cell cycle
W0016567biological_processprotein ubiquitination
W0031145biological_processanaphase-promoting complex-dependent catabolic process
W0051301biological_processcell division
W0051445biological_processregulation of meiotic cell cycle
W0070936biological_processprotein K48-linked ubiquitination
W0070979biological_processprotein K11-linked ubiquitination
W0141198biological_processprotein branched polyubiquitination
Y0000792cellular_componentheterochromatin
Y0005634cellular_componentnucleus
Y0005654cellular_componentnucleoplasm
Y0005680cellular_componentanaphase-promoting complex
Y0005737cellular_componentcytoplasm
Y0005819cellular_componentspindle
Y0005829cellular_componentcytosol
Y0005856cellular_componentcytoskeleton
Y0007346biological_processregulation of mitotic cell cycle
Y0007420biological_processbrain development
Y0015630cellular_componentmicrotubule cytoskeleton
Y0016567biological_processprotein ubiquitination
Y0019903molecular_functionprotein phosphatase binding
Y0031145biological_processanaphase-promoting complex-dependent catabolic process
Y0045842biological_processpositive regulation of mitotic metaphase/anaphase transition
Y0051301biological_processcell division
Y0051445biological_processregulation of meiotic cell cycle
Y0070936biological_processprotein K48-linked ubiquitination
Y0070979biological_processprotein K11-linked ubiquitination
Y0140767molecular_functionenzyme-substrate adaptor activity
Y0141198biological_processprotein branched polyubiquitination
Z0000792cellular_componentheterochromatin
Z0005634cellular_componentnucleus
Z0005654cellular_componentnucleoplasm
Z0005680cellular_componentanaphase-promoting complex
Z0005737cellular_componentcytoplasm
Z0005819cellular_componentspindle
Z0005829cellular_componentcytosol
Z0005856cellular_componentcytoskeleton
Z0007346biological_processregulation of mitotic cell cycle
Z0007420biological_processbrain development
Z0015630cellular_componentmicrotubule cytoskeleton
Z0016567biological_processprotein ubiquitination
Z0019903molecular_functionprotein phosphatase binding
Z0031145biological_processanaphase-promoting complex-dependent catabolic process
Z0045842biological_processpositive regulation of mitotic metaphase/anaphase transition
Z0051301biological_processcell division
Z0051445biological_processregulation of meiotic cell cycle
Z0070936biological_processprotein K48-linked ubiquitination
Z0070979biological_processprotein K11-linked ubiquitination
Z0140767molecular_functionenzyme-substrate adaptor activity
Z0141198biological_processprotein branched polyubiquitination
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues43
DetailsZN_FING: RING-type => ECO:0000255|PROSITE-ProRule:PRU00175
ChainResidueDetails
CCYS34-ARG77
ZLYS229
KSER595
QSER112
QSER490
QSER595

site_idSWS_FT_FI2
Number of Residues12
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
CCYS23
CCYS59
CCYS73
CCYS76
CCYS26
CCYS34
CCYS37
CCYS44
CCYS51
CHIS53
CHIS56
CHIS58

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332
ChainResidueDetails
NSER470
VLYS467
PSER291
PSER435

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:14657031, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
NSER534
VTHR562
PSER339
PSER438

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8BZQ7
ChainResidueDetails
NSER697
VTHR565
ILYS798

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q8BZQ7
ChainResidueDetails
NTYR810
VSER578

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332
ChainResidueDetails
UTHR582
VTHR582

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
USER588
VSER588

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
USER593
VSER593

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
UTHR596
VTHR596

site_idSWS_FT_FI11
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:28112733
ChainResidueDetails
ULYS147
VLYS147

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231
ChainResidueDetails
ASER555

site_idSWS_FT_FI13
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:14657031
ChainResidueDetails
ATYR571

site_idSWS_FT_FI14
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
ASER686

site_idSWS_FT_FI15
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:14657031, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER688

222624

PDB entries from 2024-07-17

PDB statisticsPDBj update infoContact PDBjnumon