8PKI

Cryo-EM structure of NR5A2-nucleosome complex SHL+5.5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000775	cellular_component	chromosome, centromeric region
A	0000781	cellular_component	chromosome, telomeric region
A	0000785	cellular_component	chromatin
A	0000786	cellular_component	nucleosome
A	0000939	cellular_component	inner kinetochore
A	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
A	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
A	0001556	biological_process	oocyte maturation
A	0001649	biological_process	osteoblast differentiation
A	0001740	cellular_component	Barr body
A	0003677	molecular_function	DNA binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0006334	biological_process	nucleosome assembly
A	0006997	biological_process	nucleus organization
A	0007283	biological_process	spermatogenesis
A	0007286	biological_process	spermatid development
A	0007338	biological_process	single fertilization
A	0007566	biological_process	embryo implantation
A	0008283	biological_process	cell population proliferation
A	0008584	biological_process	male gonad development
A	0030307	biological_process	positive regulation of cell growth
A	0030527	molecular_function	structural constituent of chromatin
A	0031492	molecular_function	nucleosomal DNA binding
A	0031508	biological_process	pericentric heterochromatin formation
A	0031509	biological_process	subtelomeric heterochromatin formation
A	0032991	cellular_component	protein-containing complex
A	0035264	biological_process	multicellular organism growth
A	0042692	biological_process	muscle cell differentiation
A	0046982	molecular_function	protein heterodimerization activity
A	0048477	biological_process	oogenesis
A	0090230	biological_process	regulation of centromere complex assembly
A	1902340	biological_process	negative regulation of chromosome condensation
B	0000786	cellular_component	nucleosome
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0006325	biological_process	chromatin organization
B	0006334	biological_process	nucleosome assembly
B	0030527	molecular_function	structural constituent of chromatin
B	0043505	cellular_component	CENP-A containing nucleosome
B	0046982	molecular_function	protein heterodimerization activity
B	0061644	biological_process	protein localization to CENP-A containing chromatin
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0030527	molecular_function	structural constituent of chromatin
C	0046982	molecular_function	protein heterodimerization activity
D	0000786	cellular_component	nucleosome
D	0003677	molecular_function	DNA binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0030527	molecular_function	structural constituent of chromatin
D	0046982	molecular_function	protein heterodimerization activity
E	0000775	cellular_component	chromosome, centromeric region
E	0000781	cellular_component	chromosome, telomeric region
E	0000785	cellular_component	chromatin
E	0000786	cellular_component	nucleosome
E	0000939	cellular_component	inner kinetochore
E	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
E	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
E	0001556	biological_process	oocyte maturation
E	0001649	biological_process	osteoblast differentiation
E	0001740	cellular_component	Barr body
E	0003677	molecular_function	DNA binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0006334	biological_process	nucleosome assembly
E	0006997	biological_process	nucleus organization
E	0007283	biological_process	spermatogenesis
E	0007286	biological_process	spermatid development
E	0007338	biological_process	single fertilization
E	0007566	biological_process	embryo implantation
E	0008283	biological_process	cell population proliferation
E	0008584	biological_process	male gonad development
E	0030307	biological_process	positive regulation of cell growth
E	0030527	molecular_function	structural constituent of chromatin
E	0031492	molecular_function	nucleosomal DNA binding
E	0031508	biological_process	pericentric heterochromatin formation
E	0031509	biological_process	subtelomeric heterochromatin formation
E	0032991	cellular_component	protein-containing complex
E	0035264	biological_process	multicellular organism growth
E	0042692	biological_process	muscle cell differentiation
E	0046982	molecular_function	protein heterodimerization activity
E	0048477	biological_process	oogenesis
E	0090230	biological_process	regulation of centromere complex assembly
E	1902340	biological_process	negative regulation of chromosome condensation
F	0000786	cellular_component	nucleosome
F	0003677	molecular_function	DNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005694	cellular_component	chromosome
F	0006325	biological_process	chromatin organization
F	0006334	biological_process	nucleosome assembly
F	0030527	molecular_function	structural constituent of chromatin
F	0043505	cellular_component	CENP-A containing nucleosome
F	0046982	molecular_function	protein heterodimerization activity
F	0061644	biological_process	protein localization to CENP-A containing chromatin
G	0000786	cellular_component	nucleosome
G	0003677	molecular_function	DNA binding
G	0005634	cellular_component	nucleus
G	0005694	cellular_component	chromosome
G	0030527	molecular_function	structural constituent of chromatin
G	0046982	molecular_function	protein heterodimerization activity
H	0000786	cellular_component	nucleosome
H	0003677	molecular_function	DNA binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005694	cellular_component	chromosome
H	0030527	molecular_function	structural constituent of chromatin
H	0046982	molecular_function	protein heterodimerization activity
K	0003677	molecular_function	DNA binding
K	0003700	molecular_function	DNA-binding transcription factor activity
K	0004879	molecular_function	nuclear receptor activity
K	0006355	biological_process	regulation of DNA-templated transcription
K	0008270	molecular_function	zinc ion binding
K	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PROSITE/UniProt

site_id	PS00031
Number of Residues	27
Details	NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. CpvCg.Dkvsgy.HYglltCesCkgFFkR

Chain	Residue	Details
K	CYS86-ARG112

---

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
C	ALA21-VAL27

---

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
B	GLY14-HIS18

---

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
A	LYS14-LEU20

---

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
D	ARG92-GLY114

---

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
A	PRO66-ILE74

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine; by RPS6KA5 => ECO:0000269|PubMed:7217105

Chain	Residue	Details
C	SER1
G	SER1

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000269|PubMed:16699504

Chain	Residue	Details
C	ARG3
G	ARG3

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:7217105

Chain	Residue	Details
C	LYS5
H	LYS16
H	LYS20
H	LYS85
G	LYS5
D	LYS15
D	LYS16
D	LYS20
D	LYS85
H	LYS5
H	LYS11
H	LYS15

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P20671

Chain	Residue	Details
C	LYS9
C	LYS95
G	LYS9
G	LYS95
E	LYS18
E	LYS23

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: N6-crotonyllysine; alternate => ECO:0000269|PubMed:21925322

Chain	Residue	Details
C	LYS36
G	LYS36
B	LYS44
F	LYS7
F	LYS15
F	LYS43

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: N6-(2-hydroxyisobutyryl)lysine => ECO:0000269|PubMed:24681537

Chain	Residue	Details
C	LYS74
C	LYS75
G	LYS74
G	LYS75

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N5-methylglutamine => ECO:0000269|PubMed:24352239

Chain	Residue	Details
C	GLN104
G	GLN104
H	LYS23
H	LYS43

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:P0C0S8

Chain	Residue	Details
C	LYS118
C	LYS119
C	LYS125
G	LYS118
G	LYS119
G	LYS125

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by DCAF1 => ECO:0000250|UniProtKB:P20671

Chain	Residue	Details
C	THR120
G	THR120
H	LYS34
H	LYS116

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P20671

Chain	Residue	Details
C	LYS13
C	LYS15
G	LYS13
G	LYS15

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:15509584, ECO:0000269|PubMed:15525528

Chain	Residue	Details
D	SER36
C	LYS119
E	LYS14
G	LYS119

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:P62807

Chain	Residue	Details
D	LYS46
D	LYS108
H	LYS46
H	LYS108

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	MOD_RES: N6-(2-hydroxyisobutyryl)lysine; alternate => ECO:0000269|PubMed:24681537

Chain	Residue	Details
D	LYS57
H	LYS57

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	MOD_RES: Dimethylated arginine => ECO:0000250|UniProtKB:Q96A08

Chain	Residue	Details
D	ARG79
H	ARG79

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:Q96A08

Chain	Residue	Details
D	ARG86
D	ARG92
H	ARG86
H	ARG92
F	LYS11
F	LYS19
F	LYS58
F	LYS78

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q00729

Chain	Residue	Details
D	THR115
H	THR115
F	LYS90

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435

Chain	Residue	Details
D	LYS120
H	LYS120

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250|UniProtKB:P62807

Chain	Residue	Details
D	SER112
H	SER112
E	LYS56
E	LYS79

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:P58876

Chain	Residue	Details
D	LYS5
H	LYS5

---

site_id	SWS_FT_FI20
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62807

Chain	Residue	Details
A	THR80
D	LYS34
D	LYS120
H	LYS34
H	LYS120

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:Q5QNW6

Chain	Residue	Details
D	LYS20
H	LYS20

---

site_id	SWS_FT_FI22
Number of Residues	2
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:P84243

Chain	Residue	Details
A	LYS115
E	LYS115

---

site_id	SWS_FT_FI23
Number of Residues	2
Details	LIPID: N6-decanoyllysine => ECO:0000250|UniProtKB:P84243

Chain	Residue	Details
A	LYS18
E	LYS18

---