8OVH

Crystal structure of O-acetyl-L-homoserine sulfhydrolase from Saccharomyces cerevisiae in complex with Pyridoxal-5'-phosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000097	biological_process	sulfur amino acid biosynthetic process
A	0000103	biological_process	sulfate assimilation
A	0003961	molecular_function	O-acetylhomoserine aminocarboxypropyltransferase activity
A	0004124	molecular_function	cysteine synthase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006520	biological_process	amino acid metabolic process
A	0006566	biological_process	L-threonine metabolic process
A	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
A	0019344	biological_process	L-cysteine biosynthetic process
A	0019346	biological_process	transsulfuration
A	0030170	molecular_function	pyridoxal phosphate binding
A	0051009	molecular_function	O-acetylhomoserine sulfhydrylase activity
A	0071265	biological_process	L-methionine biosynthetic process
A	0071266	biological_process	'de novo' L-methionine biosynthetic process
A	0071269	biological_process	L-homocysteine biosynthetic process
B	0000097	biological_process	sulfur amino acid biosynthetic process
B	0000103	biological_process	sulfate assimilation
B	0003961	molecular_function	O-acetylhomoserine aminocarboxypropyltransferase activity
B	0004124	molecular_function	cysteine synthase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006520	biological_process	amino acid metabolic process
B	0006566	biological_process	L-threonine metabolic process
B	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
B	0019344	biological_process	L-cysteine biosynthetic process
B	0019346	biological_process	transsulfuration
B	0030170	molecular_function	pyridoxal phosphate binding
B	0051009	molecular_function	O-acetylhomoserine sulfhydrylase activity
B	0071265	biological_process	L-methionine biosynthetic process
B	0071266	biological_process	'de novo' L-methionine biosynthetic process
B	0071269	biological_process	L-homocysteine biosynthetic process
C	0000097	biological_process	sulfur amino acid biosynthetic process
C	0000103	biological_process	sulfate assimilation
C	0003961	molecular_function	O-acetylhomoserine aminocarboxypropyltransferase activity
C	0004124	molecular_function	cysteine synthase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006520	biological_process	amino acid metabolic process
C	0006566	biological_process	L-threonine metabolic process
C	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
C	0019344	biological_process	L-cysteine biosynthetic process
C	0019346	biological_process	transsulfuration
C	0030170	molecular_function	pyridoxal phosphate binding
C	0051009	molecular_function	O-acetylhomoserine sulfhydrylase activity
C	0071265	biological_process	L-methionine biosynthetic process
C	0071266	biological_process	'de novo' L-methionine biosynthetic process
C	0071269	biological_process	L-homocysteine biosynthetic process
D	0000097	biological_process	sulfur amino acid biosynthetic process
D	0000103	biological_process	sulfate assimilation
D	0003961	molecular_function	O-acetylhomoserine aminocarboxypropyltransferase activity
D	0004124	molecular_function	cysteine synthase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006520	biological_process	amino acid metabolic process
D	0006566	biological_process	L-threonine metabolic process
D	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
D	0019344	biological_process	L-cysteine biosynthetic process
D	0019346	biological_process	transsulfuration
D	0030170	molecular_function	pyridoxal phosphate binding
D	0051009	molecular_function	O-acetylhomoserine sulfhydrylase activity
D	0071265	biological_process	L-methionine biosynthetic process
D	0071266	biological_process	'de novo' L-methionine biosynthetic process
D	0071269	biological_process	L-homocysteine biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00868
Number of Residues	15
Details	CYS_MET_METAB_PP Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. DIvthSATKWIgGHG

Chain	Residue	Details
A	ASP201-GLY215

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"source":"UniProtKB","id":"P06721","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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