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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8OUW

Cryo-EM structure of CMG helicase bound to TIM-1/TIPN-1 and homodimeric DNSN-1 on fork DNA (Caenorhabditis elegans)

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
20000166molecular_functionnucleotide binding
20000727biological_processdouble-strand break repair via break-induced replication
20000793cellular_componentcondensed chromosome
20003677molecular_functionDNA binding
20003678molecular_functionDNA helicase activity
20003697molecular_functionsingle-stranded DNA binding
20004386molecular_functionhelicase activity
20005524molecular_functionATP binding
20005634cellular_componentnucleus
20006260biological_processDNA replication
20006270biological_processDNA replication initiation
20006279biological_processpremeiotic DNA replication
20008270molecular_functionzinc ion binding
20016787molecular_functionhydrolase activity
20017116molecular_functionsingle-stranded DNA helicase activity
20042555cellular_componentMCM complex
20043138molecular_function3'-5' DNA helicase activity
20045120cellular_componentpronucleus
20046872molecular_functionmetal ion binding
21902975biological_processmitotic DNA replication initiation
30000166molecular_functionnucleotide binding
30000727biological_processdouble-strand break repair via break-induced replication
30000793cellular_componentcondensed chromosome
30003677molecular_functionDNA binding
30003678molecular_functionDNA helicase activity
30003697molecular_functionsingle-stranded DNA binding
30004386molecular_functionhelicase activity
30005524molecular_functionATP binding
30005634cellular_componentnucleus
30006260biological_processDNA replication
30006270biological_processDNA replication initiation
30006271biological_processDNA strand elongation involved in DNA replication
30006279biological_processpremeiotic DNA replication
30016787molecular_functionhydrolase activity
30017116molecular_functionsingle-stranded DNA helicase activity
30042555cellular_componentMCM complex
30045120cellular_componentpronucleus
30046872molecular_functionmetal ion binding
31902975biological_processmitotic DNA replication initiation
40000166molecular_functionnucleotide binding
40000727biological_processdouble-strand break repair via break-induced replication
40003677molecular_functionDNA binding
40003678molecular_functionDNA helicase activity
40003697molecular_functionsingle-stranded DNA binding
40004386molecular_functionhelicase activity
40005515molecular_functionprotein binding
40005524molecular_functionATP binding
40005634cellular_componentnucleus
40005694cellular_componentchromosome
40006260biological_processDNA replication
40006270biological_processDNA replication initiation
40006271biological_processDNA strand elongation involved in DNA replication
40006279biological_processpremeiotic DNA replication
40007399biological_processnervous system development
40008270molecular_functionzinc ion binding
40008406biological_processgonad development
40016787molecular_functionhydrolase activity
40016887molecular_functionATP hydrolysis activity
40017116molecular_functionsingle-stranded DNA helicase activity
40040011biological_processlocomotion
40042555cellular_componentMCM complex
40046872molecular_functionmetal ion binding
41902975biological_processmitotic DNA replication initiation
50000166molecular_functionnucleotide binding
50000727biological_processdouble-strand break repair via break-induced replication
50003677molecular_functionDNA binding
50003678molecular_functionDNA helicase activity
50003688molecular_functionDNA replication origin binding
50003697molecular_functionsingle-stranded DNA binding
50004386molecular_functionhelicase activity
50005524molecular_functionATP binding
50005634cellular_componentnucleus
50005829cellular_componentcytosol
50006260biological_processDNA replication
50006270biological_processDNA replication initiation
50006279biological_processpremeiotic DNA replication
50016787molecular_functionhydrolase activity
50016887molecular_functionATP hydrolysis activity
50017116molecular_functionsingle-stranded DNA helicase activity
50042555cellular_componentMCM complex
50043138molecular_function3'-5' DNA helicase activity
60000166molecular_functionnucleotide binding
60000724biological_processdouble-strand break repair via homologous recombination
60000727biological_processdouble-strand break repair via break-induced replication
60003677molecular_functionDNA binding
60003678molecular_functionDNA helicase activity
60003697molecular_functionsingle-stranded DNA binding
60004386molecular_functionhelicase activity
60005515molecular_functionprotein binding
60005524molecular_functionATP binding
60005634cellular_componentnucleus
60006260biological_processDNA replication
60006270biological_processDNA replication initiation
60006279biological_processpremeiotic DNA replication
60016787molecular_functionhydrolase activity
60016887molecular_functionATP hydrolysis activity
60042555cellular_componentMCM complex
61902969biological_processmitotic DNA replication
61990518molecular_functionsingle-stranded 3'-5' DNA helicase activity
70000070biological_processmitotic sister chromatid segregation
70000166molecular_functionnucleotide binding
70000727biological_processdouble-strand break repair via break-induced replication
70003677molecular_functionDNA binding
70003678molecular_functionDNA helicase activity
70003697molecular_functionsingle-stranded DNA binding
70004386molecular_functionhelicase activity
70005524molecular_functionATP binding
70005634cellular_componentnucleus
70006260biological_processDNA replication
70006270biological_processDNA replication initiation
70006271biological_processDNA strand elongation involved in DNA replication
70006279biological_processpremeiotic DNA replication
70009792biological_processembryo development ending in birth or egg hatching
70016787molecular_functionhydrolase activity
70016887molecular_functionATP hydrolysis activity
70017116molecular_functionsingle-stranded DNA helicase activity
70042555cellular_componentMCM complex
70046872molecular_functionmetal ion binding
70072689biological_processMCM complex assembly
A0000811cellular_componentGINS complex
A0005634cellular_componentnucleus
A0006260biological_processDNA replication
A1902983biological_processDNA strand elongation involved in mitotic DNA replication
B0000727biological_processdouble-strand break repair via break-induced replication
B0000811cellular_componentGINS complex
B0005634cellular_componentnucleus
B0006260biological_processDNA replication
B0071162cellular_componentCMG complex
C0000811cellular_componentGINS complex
C0005634cellular_componentnucleus
C0006260biological_processDNA replication
C0006270biological_processDNA replication initiation
D0000727biological_processdouble-strand break repair via break-induced replication
D0000811cellular_componentGINS complex
D0005634cellular_componentnucleus
D0006260biological_processDNA replication
D0006261biological_processDNA-templated DNA replication
E0000727biological_processdouble-strand break repair via break-induced replication
E0003682molecular_functionchromatin binding
E0003688molecular_functionDNA replication origin binding
E0003697molecular_functionsingle-stranded DNA binding
E0005634cellular_componentnucleus
E0006260biological_processDNA replication
E0006270biological_processDNA replication initiation
E0031261cellular_componentDNA replication preinitiation complex
E0051301biological_processcell division
E1902977biological_processmitotic DNA replication preinitiation complex assembly
F0005634cellular_componentnucleus
G0005634cellular_componentnucleus
H0005634cellular_componentnucleus
K0000076biological_processDNA replication checkpoint signaling
K0003677molecular_functionDNA binding
K0005634cellular_componentnucleus
K0006281biological_processDNA repair
K0007063biological_processregulation of sister chromatid cohesion
K0007064biological_processmitotic sister chromatid cohesion
K0009792biological_processembryo development ending in birth or egg hatching
K0031298cellular_componentreplication fork protection complex
K0043111biological_processreplication fork arrest
K0051177biological_processmeiotic sister chromatid cohesion
K0051301biological_processcell division
K0051321biological_processmeiotic cell cycle
L0000076biological_processDNA replication checkpoint signaling
L0000785cellular_componentchromatin
L0003674molecular_functionmolecular_function
L0003677molecular_functionDNA binding
L0005634cellular_componentnucleus
L0005737cellular_componentcytoplasm
L0006974biological_processDNA damage response
L0008284biological_processpositive regulation of cell population proliferation
L0031297biological_processreplication fork processing
L0031298cellular_componentreplication fork protection complex
L0031573biological_processmitotic intra-S DNA damage checkpoint signaling
L0043111biological_processreplication fork arrest
L0044770biological_processcell cycle phase transition
L0051301biological_processcell division
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FQCLVVH
ChainResidueDetails
FPHE454-HIS460
site_idPS00847
Number of Residues9
DetailsMCM_1 MCM family signature. GVVCIDEFD
ChainResidueDetails
5GLY439-ASP447
6GLY456-ASP464
3GLY407-ASP415
2GLY557-ASP565
4GLY528-ASP536
7GLY449-ASP457
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI2
Number of Residues25
DetailsZinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues21
DetailsMotif: {"description":"Walker A","evidences":[{"source":"PROSITE-ProRule","id":"PRU01410","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues9
DetailsMotif: {"description":"Walker B","evidences":[{"source":"PROSITE-ProRule","id":"PRU01410","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P33991","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues3
DetailsSite: {"description":"Arginine finger","evidences":[{"source":"PROSITE-ProRule","id":"PRU01410","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P33992","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues7
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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PDB entries from 2026-02-04

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