8OEE

Crystal structure of human AQP2 T126M mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015267	molecular_function	channel activity
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0015267	molecular_function	channel activity
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
C	0015267	molecular_function	channel activity
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
D	0015267	molecular_function	channel activity
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00221
Number of Residues	9
Details	MIP MIP family signature. HINPAVTVA

Chain	Residue	Details
A	HIS66-ALA74

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	472
Details	TRANSMEM: Helical => ECO:0000269|PubMed:24733887

Chain	Residue	Details
A	ALA12-LEU32
B	GLY128-SER148
B	PRO157-ILE176
B	TRP202-VAL222
C	ALA12-LEU32
C	VAL41-LEU59
C	ALA86-ILE107
C	GLY128-SER148
C	PRO157-ILE176
C	TRP202-VAL222
D	ALA12-LEU32
A	VAL41-LEU59
D	VAL41-LEU59
D	ALA86-ILE107
D	GLY128-SER148
D	PRO157-ILE176
D	TRP202-VAL222
A	ALA86-ILE107
A	GLY128-SER148
A	PRO157-ILE176
A	TRP202-VAL222
B	ALA12-LEU32
B	VAL41-LEU59
B	ALA86-ILE107

---

site_id	SWS_FT_FI2
Number of Residues	144
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:24733887

Chain	Residue	Details
A	ASN33-SER40
C	THR108-ALA127
C	HIS177-GLY180
C	VAL194-HIS201
D	ASN33-SER40
D	THR108-ALA127
D	HIS177-GLY180
D	VAL194-HIS201
A	THR108-ALA127
A	HIS177-GLY180
A	VAL194-HIS201
B	ASN33-SER40
B	THR108-ALA127
B	HIS177-GLY180
B	VAL194-HIS201
C	ASN33-SER40

---

site_id	SWS_FT_FI3
Number of Residues	84
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:24733887

Chain	Residue	Details
A	GLY60-GLY64
D	GLY60-GLY64
D	CYS75-ARG85
D	THR149-ASN156
A	CYS75-ARG85
A	THR149-ASN156
B	GLY60-GLY64
B	CYS75-ARG85
B	THR149-ASN156
C	GLY60-GLY64
C	CYS75-ARG85
C	THR149-ASN156

---

site_id	SWS_FT_FI4
Number of Residues	84
Details	INTRAMEM: Discontinuously helical => ECO:0000269|PubMed:24733887

Chain	Residue	Details
A	ALA65-ALA74
A	CYS181-VAL193
B	ALA65-ALA74
B	CYS181-VAL193
C	ALA65-ALA74
C	CYS181-VAL193
D	ALA65-ALA74
D	CYS181-VAL193

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN123
B	ASN123
C	ASN123
D	ASN123

---