Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8ODO

Structure of human guanylylated RTCB in complex with Archease

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001701	biological_process	in utero embryonic development
A	0001890	biological_process	placenta development
A	0003723	molecular_function	RNA binding
A	0003972	molecular_function	RNA ligase (ATP) activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005635	cellular_component	nuclear envelope
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0006388	biological_process	tRNA splicing, via endonucleolytic cleavage and ligation
A	0006396	biological_process	RNA processing
A	0008033	biological_process	tRNA processing
A	0008452	molecular_function	RNA ligase activity
A	0016874	molecular_function	ligase activity
A	0016886	molecular_function	ligase activity, forming phosphoric ester bonds
A	0017166	molecular_function	vinculin binding
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0046872	molecular_function	metal ion binding
A	0072669	cellular_component	tRNA-splicing ligase complex
A	0170057	molecular_function	RNA ligase (GTP) activity
B	0008033	biological_process	tRNA processing
B	0046872	molecular_function	metal ion binding
C	0001701	biological_process	in utero embryonic development
C	0001890	biological_process	placenta development
C	0003723	molecular_function	RNA binding
C	0003972	molecular_function	RNA ligase (ATP) activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005635	cellular_component	nuclear envelope
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005829	cellular_component	cytosol
C	0006388	biological_process	tRNA splicing, via endonucleolytic cleavage and ligation
C	0006396	biological_process	RNA processing
C	0008033	biological_process	tRNA processing
C	0008452	molecular_function	RNA ligase activity
C	0016874	molecular_function	ligase activity
C	0016886	molecular_function	ligase activity, forming phosphoric ester bonds
C	0017166	molecular_function	vinculin binding
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0046872	molecular_function	metal ion binding
C	0072669	cellular_component	tRNA-splicing ligase complex
C	0170057	molecular_function	RNA ligase (GTP) activity
D	0008033	biological_process	tRNA processing
D	0046872	molecular_function	metal ion binding
E	0001701	biological_process	in utero embryonic development
E	0001890	biological_process	placenta development
E	0003723	molecular_function	RNA binding
E	0003972	molecular_function	RNA ligase (ATP) activity
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005634	cellular_component	nucleus
E	0005635	cellular_component	nuclear envelope
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005829	cellular_component	cytosol
E	0006388	biological_process	tRNA splicing, via endonucleolytic cleavage and ligation
E	0006396	biological_process	RNA processing
E	0008033	biological_process	tRNA processing
E	0008452	molecular_function	RNA ligase activity
E	0016874	molecular_function	ligase activity
E	0016886	molecular_function	ligase activity, forming phosphoric ester bonds
E	0017166	molecular_function	vinculin binding
E	0043231	cellular_component	intracellular membrane-bounded organelle
E	0046872	molecular_function	metal ion binding
E	0072669	cellular_component	tRNA-splicing ligase complex
E	0170057	molecular_function	RNA ligase (GTP) activity
F	0008033	biological_process	tRNA processing
F	0046872	molecular_function	metal ion binding
G	0001701	biological_process	in utero embryonic development
G	0001890	biological_process	placenta development
G	0003723	molecular_function	RNA binding
G	0003972	molecular_function	RNA ligase (ATP) activity
G	0005515	molecular_function	protein binding
G	0005525	molecular_function	GTP binding
G	0005634	cellular_component	nucleus
G	0005635	cellular_component	nuclear envelope
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0005829	cellular_component	cytosol
G	0006388	biological_process	tRNA splicing, via endonucleolytic cleavage and ligation
G	0006396	biological_process	RNA processing
G	0008033	biological_process	tRNA processing
G	0008452	molecular_function	RNA ligase activity
G	0016874	molecular_function	ligase activity
G	0016886	molecular_function	ligase activity, forming phosphoric ester bonds
G	0017166	molecular_function	vinculin binding
G	0043231	cellular_component	intracellular membrane-bounded organelle
G	0046872	molecular_function	metal ion binding
G	0072669	cellular_component	tRNA-splicing ligase complex
G	0170057	molecular_function	RNA ligase (GTP) activity
H	0008033	biological_process	tRNA processing
H	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS01288
Number of Residues	30
Details	UPF0027 Uncharacterized protein family UPF0027 signature. QIgNvAaLPgIvhrsigLPDvHsGyGfaIG

Chain	Residue	Details
A	GLN68-GLY97

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: GMP-histidine intermediate => ECO:0000250\|UniProtKB:O59245, ECO:0000255\|HAMAP-Rule:MF_03144

Chain	Residue	Details
A	HIS428
C	HIS428
E	HIS428
G	HIS428

site_id	SWS_FT_FI2
Number of Residues	40
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:O59245, ECO:0000255\|HAMAP-Rule:MF_03144

Chain	Residue	Details
A	ASP119
A	LYS504
C	ASP119
C	CYS122
C	ASN226
C	HIS227
C	HIS259
C	HIS353
C	GLY402
C	SER409
C	HIS428
A	CYS122
C	LYS504
E	ASP119
E	CYS122
E	ASN226
E	HIS227
E	HIS259
E	HIS353
E	GLY402
E	SER409
E	HIS428
A	ASN226
E	LYS504
G	ASP119
G	CYS122
G	ASN226
G	HIS227
G	HIS259
G	HIS353
G	GLY402
G	SER409
G	HIS428
A	HIS227
G	LYS504
A	HIS259
A	HIS353
A	GLY402
A	SER409
A	HIS428

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER300
C	SER300
E	SER300
G	SER300

site_id	SWS_FT_FI4
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
A	LYS496
C	LYS496
E	LYS496
G	LYS496

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)