8ODO

Structure of human guanylylated RTCB in complex with Archease

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000394	biological_process	RNA splicing, via endonucleolytic cleavage and ligation
A	0000968	biological_process	tRNA exon ligation
A	0003723	molecular_function	RNA binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005635	cellular_component	nuclear envelope
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0006388	biological_process	tRNA splicing, via endonucleolytic cleavage and ligation
A	0006396	biological_process	RNA processing
A	0008033	biological_process	tRNA processing
A	0008452	molecular_function	RNA ligase activity
A	0016874	molecular_function	ligase activity
A	0016886	molecular_function	ligase activity, forming phosphoric ester bonds
A	0017166	molecular_function	vinculin binding
A	0036498	biological_process	IRE1-mediated unfolded protein response
A	0044600	molecular_function	protein guanylyltransferase activity
A	0046872	molecular_function	metal ion binding
A	0070054	biological_process	mRNA splicing, via endonucleolytic cleavage and ligation
A	0072669	cellular_component	tRNA-splicing ligase complex
A	0170057	molecular_function	RNA ligase (GTP) activity
A	1902494	cellular_component	catalytic complex
B	0000394	biological_process	RNA splicing, via endonucleolytic cleavage and ligation
B	0000968	biological_process	tRNA exon ligation
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0006388	biological_process	tRNA splicing, via endonucleolytic cleavage and ligation
B	0008033	biological_process	tRNA processing
B	0016740	molecular_function	transferase activity
B	0036498	biological_process	IRE1-mediated unfolded protein response
B	0044600	molecular_function	protein guanylyltransferase activity
B	0046872	molecular_function	metal ion binding
B	0070054	biological_process	mRNA splicing, via endonucleolytic cleavage and ligation
B	0072669	cellular_component	tRNA-splicing ligase complex
B	0170057	molecular_function	RNA ligase (GTP) activity
B	1902494	cellular_component	catalytic complex
C	0000166	molecular_function	nucleotide binding
C	0000394	biological_process	RNA splicing, via endonucleolytic cleavage and ligation
C	0000968	biological_process	tRNA exon ligation
C	0003723	molecular_function	RNA binding
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005635	cellular_component	nuclear envelope
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005829	cellular_component	cytosol
C	0006388	biological_process	tRNA splicing, via endonucleolytic cleavage and ligation
C	0006396	biological_process	RNA processing
C	0008033	biological_process	tRNA processing
C	0008452	molecular_function	RNA ligase activity
C	0016874	molecular_function	ligase activity
C	0016886	molecular_function	ligase activity, forming phosphoric ester bonds
C	0017166	molecular_function	vinculin binding
C	0036498	biological_process	IRE1-mediated unfolded protein response
C	0044600	molecular_function	protein guanylyltransferase activity
C	0046872	molecular_function	metal ion binding
C	0070054	biological_process	mRNA splicing, via endonucleolytic cleavage and ligation
C	0072669	cellular_component	tRNA-splicing ligase complex
C	0170057	molecular_function	RNA ligase (GTP) activity
C	1902494	cellular_component	catalytic complex
D	0000394	biological_process	RNA splicing, via endonucleolytic cleavage and ligation
D	0000968	biological_process	tRNA exon ligation
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0006388	biological_process	tRNA splicing, via endonucleolytic cleavage and ligation
D	0008033	biological_process	tRNA processing
D	0016740	molecular_function	transferase activity
D	0036498	biological_process	IRE1-mediated unfolded protein response
D	0044600	molecular_function	protein guanylyltransferase activity
D	0046872	molecular_function	metal ion binding
D	0070054	biological_process	mRNA splicing, via endonucleolytic cleavage and ligation
D	0072669	cellular_component	tRNA-splicing ligase complex
D	0170057	molecular_function	RNA ligase (GTP) activity
D	1902494	cellular_component	catalytic complex
E	0000166	molecular_function	nucleotide binding
E	0000394	biological_process	RNA splicing, via endonucleolytic cleavage and ligation
E	0000968	biological_process	tRNA exon ligation
E	0003723	molecular_function	RNA binding
E	0005525	molecular_function	GTP binding
E	0005634	cellular_component	nucleus
E	0005635	cellular_component	nuclear envelope
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005829	cellular_component	cytosol
E	0006388	biological_process	tRNA splicing, via endonucleolytic cleavage and ligation
E	0006396	biological_process	RNA processing
E	0008033	biological_process	tRNA processing
E	0008452	molecular_function	RNA ligase activity
E	0016874	molecular_function	ligase activity
E	0016886	molecular_function	ligase activity, forming phosphoric ester bonds
E	0017166	molecular_function	vinculin binding
E	0036498	biological_process	IRE1-mediated unfolded protein response
E	0044600	molecular_function	protein guanylyltransferase activity
E	0046872	molecular_function	metal ion binding
E	0070054	biological_process	mRNA splicing, via endonucleolytic cleavage and ligation
E	0072669	cellular_component	tRNA-splicing ligase complex
E	0170057	molecular_function	RNA ligase (GTP) activity
E	1902494	cellular_component	catalytic complex
F	0000394	biological_process	RNA splicing, via endonucleolytic cleavage and ligation
F	0000968	biological_process	tRNA exon ligation
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0006388	biological_process	tRNA splicing, via endonucleolytic cleavage and ligation
F	0008033	biological_process	tRNA processing
F	0016740	molecular_function	transferase activity
F	0036498	biological_process	IRE1-mediated unfolded protein response
F	0044600	molecular_function	protein guanylyltransferase activity
F	0046872	molecular_function	metal ion binding
F	0070054	biological_process	mRNA splicing, via endonucleolytic cleavage and ligation
F	0072669	cellular_component	tRNA-splicing ligase complex
F	0170057	molecular_function	RNA ligase (GTP) activity
F	1902494	cellular_component	catalytic complex
G	0000166	molecular_function	nucleotide binding
G	0000394	biological_process	RNA splicing, via endonucleolytic cleavage and ligation
G	0000968	biological_process	tRNA exon ligation
G	0003723	molecular_function	RNA binding
G	0005525	molecular_function	GTP binding
G	0005634	cellular_component	nucleus
G	0005635	cellular_component	nuclear envelope
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0005829	cellular_component	cytosol
G	0006388	biological_process	tRNA splicing, via endonucleolytic cleavage and ligation
G	0006396	biological_process	RNA processing
G	0008033	biological_process	tRNA processing
G	0008452	molecular_function	RNA ligase activity
G	0016874	molecular_function	ligase activity
G	0016886	molecular_function	ligase activity, forming phosphoric ester bonds
G	0017166	molecular_function	vinculin binding
G	0036498	biological_process	IRE1-mediated unfolded protein response
G	0044600	molecular_function	protein guanylyltransferase activity
G	0046872	molecular_function	metal ion binding
G	0070054	biological_process	mRNA splicing, via endonucleolytic cleavage and ligation
G	0072669	cellular_component	tRNA-splicing ligase complex
G	0170057	molecular_function	RNA ligase (GTP) activity
G	1902494	cellular_component	catalytic complex
H	0000394	biological_process	RNA splicing, via endonucleolytic cleavage and ligation
H	0000968	biological_process	tRNA exon ligation
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0006388	biological_process	tRNA splicing, via endonucleolytic cleavage and ligation
H	0008033	biological_process	tRNA processing
H	0016740	molecular_function	transferase activity
H	0036498	biological_process	IRE1-mediated unfolded protein response
H	0044600	molecular_function	protein guanylyltransferase activity
H	0046872	molecular_function	metal ion binding
H	0070054	biological_process	mRNA splicing, via endonucleolytic cleavage and ligation
H	0072669	cellular_component	tRNA-splicing ligase complex
H	0170057	molecular_function	RNA ligase (GTP) activity
H	1902494	cellular_component	catalytic complex

Functional Information from PROSITE/UniProt

site_id	PS01288
Number of Residues	30
Details	UPF0027 Uncharacterized protein family UPF0027 signature. QIgNvAaLPgIvhrsigLPDvHsGyGfaIG

Chain	Residue	Details
A	GLN68-GLY97

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"GMP-histidine intermediate","evidences":[{"source":"UniProtKB","id":"O59245","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_03144","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	72
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"O59245","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_03144","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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