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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8K9I

Structure of CUL3-RBX1-KLHL22 complex without CUL3 NA motif

Functional Information from GO Data
ChainGOidnamespacecontents
C0000082biological_processG1/S transition of mitotic cell cycle
C0000209biological_processprotein polyubiquitination
C0000278biological_processmitotic cell cycle
C0000922cellular_componentspindle pole
C0001822biological_processkidney development
C0004842molecular_functionubiquitin-protein transferase activity
C0005112molecular_functionNotch binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005794cellular_componentGolgi apparatus
C0005813cellular_componentcentrosome
C0005819cellular_componentspindle
C0005827cellular_componentpolar microtubule
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006511biological_processubiquitin-dependent protein catabolic process
C0006513biological_processprotein monoubiquitination
C0006888biological_processendoplasmic reticulum to Golgi vesicle-mediated transport
C0006915biological_processapoptotic process
C0006950biological_processresponse to stress
C0006954biological_processinflammatory response
C0007080biological_processmitotic metaphase chromosome alignment
C0007165biological_processsignal transduction
C0007229biological_processintegrin-mediated signaling pathway
C0008284biological_processpositive regulation of cell population proliferation
C0010467biological_processgene expression
C0010468biological_processregulation of gene expression
C0015630cellular_componentmicrotubule cytoskeleton
C0016020cellular_componentmembrane
C0016192biological_processvesicle-mediated transport
C0016477biological_processcell migration
C0016567biological_processprotein ubiquitination
C0017145biological_processstem cell division
C0030030biological_processcell projection organization
C0030163biological_processprotein catabolic process
C0030332molecular_functioncyclin binding
C0031145biological_processanaphase-promoting complex-dependent catabolic process
C0031208molecular_functionPOZ domain binding
C0031398biological_processpositive regulation of protein ubiquitination
C0031461cellular_componentcullin-RING ubiquitin ligase complex
C0031463cellular_componentCul3-RING ubiquitin ligase complex
C0031514cellular_componentmotile cilium
C0031625molecular_functionubiquitin protein ligase binding
C0031648biological_processprotein destabilization
C0032467biological_processpositive regulation of cytokinesis
C0032480biological_processnegative regulation of type I interferon production
C0034599biological_processcellular response to oxidative stress
C0035024biological_processnegative regulation of Rho protein signal transduction
C0036126cellular_componentsperm flagellum
C0040016biological_processembryonic cleavage
C0042802molecular_functionidentical protein binding
C0043149biological_processstress fiber assembly
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0045842biological_processpositive regulation of mitotic metaphase/anaphase transition
C0048208biological_processCOPII vesicle coating
C0051301biological_processcell division
C0051865biological_processprotein autoubiquitination
C0061630molecular_functionubiquitin protein ligase activity
C0070062cellular_componentextracellular exosome
C0070936biological_processprotein K48-linked ubiquitination
C0071230biological_processcellular response to amino acid stimulus
C0071630biological_processnuclear protein quality control by the ubiquitin-proteasome system
C0072686cellular_componentmitotic spindle
C0080090biological_processregulation of primary metabolic process
C0097193biological_processintrinsic apoptotic signaling pathway
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0140252biological_processregulation protein catabolic process at postsynapse
C0160072molecular_functionubiquitin ligase complex scaffold activity
C1900076biological_processregulation of cellular response to insulin stimulus
C1901992biological_processpositive regulation of mitotic cell cycle phase transition
C1904263biological_processpositive regulation of TORC1 signaling
R0000082biological_processG1/S transition of mitotic cell cycle
R0000122biological_processnegative regulation of transcription by RNA polymerase II
R0000165biological_processMAPK cascade
R0000209biological_processprotein polyubiquitination
R0004842molecular_functionubiquitin-protein transferase activity
R0005515molecular_functionprotein binding
R0005634cellular_componentnucleus
R0005654cellular_componentnucleoplasm
R0005737cellular_componentcytoplasm
R0005794cellular_componentGolgi apparatus
R0005813cellular_componentcentrosome
R0005829cellular_componentcytosol
R0006281biological_processDNA repair
R0006283biological_processtranscription-coupled nucleotide-excision repair
R0006289biological_processnucleotide-excision repair
R0006355biological_processregulation of DNA-templated transcription
R0006511biological_processubiquitin-dependent protein catabolic process
R0006513biological_processprotein monoubiquitination
R0006879biological_processintracellular iron ion homeostasis
R0006974biological_processDNA damage response
R0007283biological_processspermatogenesis
R0007346biological_processregulation of mitotic cell cycle
R0008270molecular_functionzinc ion binding
R0008283biological_processcell population proliferation
R0010506biological_processregulation of autophagy
R0010564biological_processregulation of cell cycle process
R0010824biological_processregulation of centrosome duplication
R0014033biological_processneural crest cell differentiation
R0016567biological_processprotein ubiquitination
R0016740molecular_functiontransferase activity
R0019005cellular_componentSCF ubiquitin ligase complex
R0019788molecular_functionNEDD8 transferase activity
R0030174biological_processregulation of DNA-templated DNA replication initiation
R0030510biological_processregulation of BMP signaling pathway
R0030891cellular_componentVCB complex
R0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
R0031297biological_processreplication fork processing
R0031461cellular_componentcullin-RING ubiquitin ligase complex
R0031462cellular_componentCul2-RING ubiquitin ligase complex
R0031463cellular_componentCul3-RING ubiquitin ligase complex
R0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
R0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
R0031466cellular_componentCul5-RING ubiquitin ligase complex
R0031467cellular_componentCul7-RING ubiquitin ligase complex
R0031625molecular_functionubiquitin protein ligase binding
R0032006biological_processregulation of TOR signaling
R0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
R0032480biological_processnegative regulation of type I interferon production
R0032814biological_processregulation of natural killer cell activation
R0034450molecular_functionubiquitin-ubiquitin ligase activity
R0034599biological_processcellular response to oxidative stress
R0034644biological_processcellular response to UV
R0040029biological_processepigenetic regulation of gene expression
R0042110biological_processT cell activation
R0042127biological_processregulation of cell population proliferation
R0042752biological_processregulation of circadian rhythm
R0042770biological_processsignal transduction in response to DNA damage
R0042981biological_processregulation of apoptotic process
R0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
R0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
R0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
R0043687biological_processpost-translational protein modification
R0044314biological_processprotein K27-linked ubiquitination
R0044877molecular_functionprotein-containing complex binding
R0045116biological_processprotein neddylation
R0045732biological_processpositive regulation of protein catabolic process
R0045995biological_processregulation of embryonic development
R0046627biological_processnegative regulation of insulin receptor signaling pathway
R0046872molecular_functionmetal ion binding
R0050727biological_processregulation of inflammatory response
R0051298biological_processcentrosome duplication
R0051726biological_processregulation of cell cycle
R0060090molecular_functionmolecular adaptor activity
R0060173biological_processlimb development
R0060271biological_processcilium assembly
R0060964biological_processregulation of miRNA-mediated gene silencing
R0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
R0061630molecular_functionubiquitin protein ligase activity
R0061663molecular_functionNEDD8 ligase activity
R0062197biological_processcellular response to chemical stress
R0070936biological_processprotein K48-linked ubiquitination
R0071230biological_processcellular response to amino acid stimulus
R0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
R0080135biological_processregulation of cellular response to stress
R0090090biological_processnegative regulation of canonical Wnt signaling pathway
R0090734cellular_componentsite of DNA damage
R0097602molecular_functioncullin family protein binding
R0140627biological_processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
R0160240biological_processRNA polymerase II transcription initiation surveillance
R0160276biological_processnegative regulation of beige fat cell differentiation
R1900076biological_processregulation of cellular response to insulin stimulus
R1901524biological_processregulation of mitophagy
R1901525biological_processnegative regulation of mitophagy
R1901987biological_processregulation of cell cycle phase transition
R1902412biological_processregulation of mitotic cytokinesis
R1902499biological_processpositive regulation of protein autoubiquitination
R1902883biological_processnegative regulation of response to oxidative stress
R1904178biological_processnegative regulation of adipose tissue development
R1904263biological_processpositive regulation of TORC1 signaling
R1904415biological_processregulation of xenophagy
R1990116biological_processribosome-associated ubiquitin-dependent protein catabolic process
R2000001biological_processregulation of DNA damage checkpoint
R2000036biological_processregulation of stem cell population maintenance
R2000104biological_processnegative regulation of DNA-templated DNA replication
Functional Information from PROSITE/UniProt
site_idPS01256
Number of Residues28
DetailsCULLIN_1 Cullin family signature. IKkrIegLIEReYLaRtpedrkvYtYvA
ChainResidueDetails
CILE741-ALA768
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues62
DetailsDomain: {"description":"Cullin neddylation","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)","evidences":[{"source":"UniProtKB","id":"Q13616","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Z8B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

247947

PDB entries from 2026-01-21

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