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8JD6

Cryo-EM structure of Gi1-bound metabotropic glutamate receptor mGlu4

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0001664molecular_functionG protein-coupled receptor binding
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005765cellular_componentlysosomal membrane
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005813cellular_componentcentrosome
A0005834cellular_componentheterotrimeric G-protein complex
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A0007194biological_processnegative regulation of adenylate cyclase activity
A0007212biological_processG protein-coupled dopamine receptor signaling pathway
A0016020cellular_componentmembrane
A0016239biological_processpositive regulation of macroautophagy
A0019001molecular_functionguanyl nucleotide binding
A0019003molecular_functionGDP binding
A0030496cellular_componentmidbody
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0046039biological_processGTP metabolic process
A0046872molecular_functionmetal ion binding
A0051301biological_processcell division
A0070062cellular_componentextracellular exosome
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
C0005515molecular_functionprotein binding
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
C0016020cellular_componentmembrane
C0031681molecular_functionG-protein beta-subunit binding
C0045202cellular_componentsynapse
C0048144biological_processfibroblast proliferation
C0070062cellular_componentextracellular exosome
C0071380biological_processcellular response to prostaglandin E stimulus
C0071870biological_processcellular response to catecholamine stimulus
R0001640molecular_functionadenylate cyclase inhibiting G protein-coupled glutamate receptor activity
R0004930molecular_functionG protein-coupled receptor activity
R0005886cellular_componentplasma membrane
R0007186biological_processG protein-coupled receptor signaling pathway
R0007196biological_processadenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
R0007216biological_processG protein-coupled glutamate receptor signaling pathway
R0007268biological_processchemical synaptic transmission
R0007269biological_processneurotransmitter secretion
R0008066molecular_functionglutamate receptor activity
R0016020cellular_componentmembrane
R0031410cellular_componentcytoplasmic vesicle
R0043410biological_processpositive regulation of MAPK cascade
R0043523biological_processregulation of neuron apoptotic process
R0045202cellular_componentsynapse
R0051966biological_processregulation of synaptic transmission, glutamatergic
R0098793cellular_componentpresynapse
S0001640molecular_functionadenylate cyclase inhibiting G protein-coupled glutamate receptor activity
S0004930molecular_functionG protein-coupled receptor activity
S0005886cellular_componentplasma membrane
S0007186biological_processG protein-coupled receptor signaling pathway
S0007196biological_processadenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
S0007216biological_processG protein-coupled glutamate receptor signaling pathway
S0007268biological_processchemical synaptic transmission
S0007269biological_processneurotransmitter secretion
S0008066molecular_functionglutamate receptor activity
S0016020cellular_componentmembrane
S0031410cellular_componentcytoplasmic vesicle
S0043410biological_processpositive regulation of MAPK cascade
S0043523biological_processregulation of neuron apoptotic process
S0045202cellular_componentsynapse
S0051966biological_processregulation of synaptic transmission, glutamatergic
S0098793cellular_componentpresynapse
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

site_idPS00979
Number of Residues19
DetailsG_PROTEIN_RECEP_F3_1 G-protein coupled receptors family 3 signature 1. VaNILrLFkIPQISyASTA
ChainResidueDetails
SVAL165-ALA183

site_idPS00980
Number of Residues23
DetailsG_PROTEIN_RECEP_F3_2 G-protein coupled receptors family 3 signature 2. CCWhCepCtgyqYqv...DryTCktC
ChainResidueDetails
SCYS538-CYS560

site_idPS00981
Number of Residues11
DetailsG_PROTEIN_RECEP_F3_3 G-protein coupled receptors family 3 signature 3. FNEAKpIGFTM
ChainResidueDetails
SPHE781-MET791

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0007744|PDB:2IHB, ECO:0007744|PDB:2ODE, ECO:0007744|PDB:2V4Z, ECO:0007744|PDB:4G5O, ECO:0007744|PDB:4G5R, ECO:0007744|PDB:4G5S
ChainResidueDetails
AGLU43
ALEU175
AASN269
SSER809-THR821
RLYS33-TRP587
RGLU646-ARG656
RASP721-ASP750
RSER809-THR821

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:19478087, ECO:0007744|PDB:2V4Z
ChainResidueDetails
AASN47
ATHR181

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0007744|PDB:2V4Z, ECO:0007744|PDB:4G5O, ECO:0007744|PDB:4G5R, ECO:0007744|PDB:4G5S
ChainResidueDetails
AASP150
SARG676-GLN699
SLYS773-LYS785
SHIS848-ILE912
RARG611-GLU624
RARG676-GLN699
RLYS773-LYS785
RHIS848-ILE912

site_idSWS_FT_FI4
Number of Residues1
DetailsBINDING: BINDING => ECO:0000305|PubMed:19478087, ECO:0007744|PDB:2V4Z
ChainResidueDetails
AASP200
RLEU625-ALA645

site_idSWS_FT_FI5
Number of Residues1
DetailsBINDING: BINDING => ECO:0007744|PDB:2IHB, ECO:0007744|PDB:2ODE, ECO:0007744|PDB:2V4Z, ECO:0007744|PDB:4G5O, ECO:0007744|PDB:4G5R
ChainResidueDetails
ASER326
RILE657-ASN675

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: ADP-ribosylarginine; by cholera toxin => ECO:0000250
ChainResidueDetails
AARG178
RLEU700-VAL720

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Deamidated glutamine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704
ChainResidueDetails
AGLN204
RLEU751-ILE772

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: ADP-ribosylcysteine; by pertussis toxin => ECO:0000250
ChainResidueDetails
ACYS351
RPRO786-THR808

site_idSWS_FT_FI9
Number of Residues1
DetailsLIPID: N-myristoyl glycine => ECO:0000269|PubMed:25255805
ChainResidueDetails
AGLY2
RLEU822-PHE847

site_idSWS_FT_FI10
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250
ChainResidueDetails
ACYS3
RLYS405
SALA180
STYR230
SASP312
SLYS405
RSER159
RALA180
RTYR230
RASP312

site_idSWS_FT_FI11
Number of Residues10
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
SASN98
RASN569
SASN301
SASN454
SASN484
SASN569
RASN98
RASN301
RASN454
RASN484

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PDB entries from 2024-10-16

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