2V4Z
The crystal structure of the human G-protein subunit alpha (GNAI3) in complex with an engineered regulator of G-protein signaling type 2 domain (RGS2)
Summary for 2V4Z
Entry DOI | 10.2210/pdb2v4z/pdb |
Related | 2AF0 2IHB |
Descriptor | GUANINE NUCLEOTIDE-BINDING PROTEIN G(K) SUBUNIT ALPHA, REGULATOR OF G-PROTEIN SIGNALING 2, GUANOSINE-5'-DIPHOSPHATE, ... (6 entities in total) |
Functional Keywords | gtp hydrolysis, adp-ribosylation, nucleotide-binding, lipoprotein, gtp-binding, phosphoprotein, signal transduction inhibitor, guanine nucleotide binding protein, transmembrane signaling, g-protein coupled receptor, palmitate, myristate, transducer, cell cycle |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Isoform 1: Cell membrane . Isoform 2: Cell membrane . Isoform 3: Cell membrane . Isoform 4: Cell membrane : P41220 |
Total number of polymer chains | 2 |
Total formula weight | 57193.59 |
Authors | Roos, A.K.,Soundararajan, M.,Pike, A.C.W.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.,Bountra, C.,Knapp, S. (deposition date: 2008-09-30, release date: 2008-11-04, Last modification date: 2023-12-13) |
Primary citation | Kimple, A.J.,Soundararajan, M.,Hutsell, S.Q.,Roos, A.K.,Urban, D.J.,Setola, V.,Temple, B.R.,Roth, B.L.,Knapp, S.,Willard, F.S.,Siderovski, D.P. Structural Determinants of G-Protein Alpha Subunit Selectivity by Regulator of G-Protein Signaling 2(Rgs2). J.Biol.Chem., 284:19402-, 2009 Cited by PubMed: 19478087DOI: 10.1074/JBC.M109.024711 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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