2V4Z

The crystal structure of the human G-protein subunit alpha (GNAI3) in complex with an engineered regulator of G-protein signaling type 2 domain (RGS2)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	GUANINE NUCLEOTIDE-BINDING PROTEIN G(K) SUBUNIT ALPHA	polymer	350	40162.6	1	UniProt (P08754) Pfam (PF00503)	HOMO SAPIENS (HUMAN)	G(I) ALPHA-3, GUANINE NUCLEOTIDE-BINDING PROTEIN G K SUBUNIT ALPHA G I ALPHA-3
2	B (B)	REGULATOR OF G-PROTEIN SIGNALING 2	polymer	142	16460.5	1	UniProt (P41220) Pfam (PF00615)	HOMO SAPIENS (HUMAN)	G0/G1 SWITCH REGULATORY PROTEIN 8, RGS2, CELL GROWTH-INHIBITING GENE 31 PROTEIN
3	C (A)	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	1	Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537)
4	D (A)	TETRAFLUOROALUMINATE ION	non-polymer		103.0	1	Chemie (ALF) PubChem (5311325)
5	E (A)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG) PubChem (888)
6	F, G (A, B)	water	water		18.0	18	Chemie (HOH)

Sequence modifications

A: 2 - 3 (PDB: 2V4Z)
A: 351 - 351 (PDB: 2V4Z)
A: 4 - 350 (UniProt: P08754)
B: 68 - 70 (PDB: 2V4Z)
B: 71 - 209 (UniProt: P41220)

PDB	External Database	Details
Ser 106	Cys 106	engineered mutation
Asp 184	Asn 184	engineered mutation
Lys 191	Glu 191	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	56623.1
Non-Polymers*	Number of molecules	3
	Total formula weight	570.5
All*	Total formula weight	57193.6

*Water molecules are not included.