4G5S

Structure of LGN GL3/Galphai3 complex

Summary for 4G5S

• Entry DOI: 10.2210/pdb4g5s/pdb
• Related: 4G5O 4G5Q 4G5R
• Descriptor: Guanine nucleotide-binding protein G(k) subunit alpha, G-protein-signaling modulator 2, GUANOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: galpha, goloco, galpha signaling, asymmetric cell division, cell cycle-signaling protein complex, cell cycle/signaling protein
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P08754; Cytoplasm (By similarity): Q8VDU0
• Total number of polymer chains: 8
• Total formula weight: 164758.52

Authors

Jia, M.,Li, J.,Zhu, J.,Wen, W.,Zhang, M.,Wang, W. (deposition date: 2012-07-18, release date: 2012-09-05, Last modification date: 2024-03-20)

• Primary citation: Jia, M.,Li, J.,Zhu, J.,Wen, W.,Zhang, M.,Wang, W.; Crystal Structures of the scaffolding protein LGN reveal the general mechanism by which GoLoco binding motifs inhibit the release of GDP from Galphai subunits in G-coupled heterotrimeric proteins; To be Published,

Experimental method

X-RAY DIFFRACTION (3.62 Å)