4G5S

Structure of LGN GL3/Galphai3 complex

Summary for 4G5S

Related4G5O 4G5Q 4G5R
DescriptorGuanine nucleotide-binding protein G(k) subunit alpha, G-protein-signaling modulator 2, GUANOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
Functional Keywordsgalpha, goloco, galpha signaling, asymmetric cell division, cell cycle-signaling protein complex, cell cycle/signaling protein
Biological sourceHomo sapiens (human)
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Cellular locationCytoplasm P08754
Cytoplasm (By similarity) Q8VDU0
Total number of polymer chains8
Total molecular weight164758.52
Authors
Jia, M.,Li, J.,Zhu, J.,Wen, W.,Zhang, M.,Wang, W. (deposition date: 2012-07-18, release date: 2012-09-05)
Primary citation
Jia, M.,Li, J.,Zhu, J.,Wen, W.,Zhang, M.,Wang, W.
Crystal Structures of the scaffolding protein LGN reveal the general mechanism by which GoLoco binding motifs inhibit the release of GDP from Galphai subunits in G-coupled heterotrimeric proteins
To be Published,
Experimental method
X-RAY DIFFRACTION (3.62 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25580.8%5.6%0.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4g5s
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Molmil generated image of 4g5s
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Molmil generated image of 4g5s
rotated about y axis by 90°