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8JC5

Crystal structure of PLEKHM1 RUN domain in complex with GTP-bound Arl8b(Q75L)

Functional Information from GO Data
ChainGOidnamespacecontents
A0001778biological_processplasma membrane repair
A0002505biological_processantigen processing and presentation of polysaccharide antigen via MHC class II
A0002747biological_processantigen processing and presentation following phagocytosis
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005768cellular_componentendosome
A0005819cellular_componentspindle
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0007059biological_processchromosome segregation
A0008089biological_processanterograde axonal transport
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0016197biological_processendosomal transport
A0016787molecular_functionhydrolase activity
A0019003molecular_functionGDP binding
A0030424cellular_componentaxon
A0030496cellular_componentmidbody
A0031901cellular_componentearly endosome membrane
A0031902cellular_componentlate endosome membrane
A0032418biological_processlysosome localization
A0034498biological_processearly endosome to Golgi transport
A0042267biological_processnatural killer cell mediated cytotoxicity
A0042995cellular_componentcell projection
A0043014molecular_functionalpha-tubulin binding
A0045202cellular_componentsynapse
A0046754biological_processviral exocytosis
A0048487molecular_functionbeta-tubulin binding
A0051233cellular_componentspindle midzone
A0051301biological_processcell division
A0061909biological_processautophagosome-lysosome fusion
A0070062cellular_componentextracellular exosome
A0090117biological_processendosome to lysosome transport of low-density lipoprotein particle
A0090385biological_processphagosome-lysosome fusion
A0101004cellular_componentcytolytic granule membrane
A1902774biological_processlate endosome to lysosome transport
A1902946biological_processprotein localization to early endosome
A1904115cellular_componentaxon cytoplasm
A1990927biological_processcalcium ion regulated lysosome exocytosis
B0001778biological_processplasma membrane repair
B0002505biological_processantigen processing and presentation of polysaccharide antigen via MHC class II
B0002747biological_processantigen processing and presentation following phagocytosis
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005768cellular_componentendosome
B0005819cellular_componentspindle
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0007059biological_processchromosome segregation
B0008089biological_processanterograde axonal transport
B0015031biological_processprotein transport
B0016020cellular_componentmembrane
B0016197biological_processendosomal transport
B0016787molecular_functionhydrolase activity
B0019003molecular_functionGDP binding
B0030424cellular_componentaxon
B0030496cellular_componentmidbody
B0031901cellular_componentearly endosome membrane
B0031902cellular_componentlate endosome membrane
B0032418biological_processlysosome localization
B0034498biological_processearly endosome to Golgi transport
B0042267biological_processnatural killer cell mediated cytotoxicity
B0042995cellular_componentcell projection
B0043014molecular_functionalpha-tubulin binding
B0045202cellular_componentsynapse
B0046754biological_processviral exocytosis
B0048487molecular_functionbeta-tubulin binding
B0051233cellular_componentspindle midzone
B0051301biological_processcell division
B0061909biological_processautophagosome-lysosome fusion
B0070062cellular_componentextracellular exosome
B0090117biological_processendosome to lysosome transport of low-density lipoprotein particle
B0090385biological_processphagosome-lysosome fusion
B0101004cellular_componentcytolytic granule membrane
B1902774biological_processlate endosome to lysosome transport
B1902946biological_processprotein localization to early endosome
B1904115cellular_componentaxon cytoplasm
B1990927biological_processcalcium ion regulated lysosome exocytosis
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|Ref.26
ChainResidueDetails
AGLN29
AASN130
BGLN29
BASN130

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P62330
ChainResidueDetails
AASP71
BASP71

site_idSWS_FT_FI3
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:27808481
ChainResidueDetails
ALYS141
BLYS141

226707

PDB entries from 2024-10-30

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