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8J22

Cryo-EM structure of FFAR2 complex bound with TUG-1375

Functional Information from GO Data
ChainGOidnamespacecontents
A0001750cellular_componentphotoreceptor outer segment
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005765cellular_componentlysosomal membrane
A0005829cellular_componentcytosol
A0005834cellular_componentheterotrimeric G-protein complex
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
A0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
A0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
A0007265biological_processRas protein signal transduction
A0008283biological_processcell population proliferation
A0016020cellular_componentmembrane
A0030159molecular_functionsignaling receptor complex adaptor activity
A0044877molecular_functionprotein-containing complex binding
A0045202cellular_componentsynapse
A0050909biological_processsensory perception of taste
A0051020molecular_functionGTPase binding
A0060041biological_processretina development in camera-type eye
A0070062cellular_componentextracellular exosome
A0071380biological_processcellular response to prostaglandin E stimulus
A0071870biological_processcellular response to catecholamine stimulus
A0097381cellular_componentphotoreceptor disc membrane
A1903561cellular_componentextracellular vesicle
B0000287molecular_functionmagnesium ion binding
B0001664molecular_functionG protein-coupled receptor binding
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005813cellular_componentcentrosome
B0005834cellular_componentheterotrimeric G-protein complex
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0005938cellular_componentcell cortex
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
B0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
B0016020cellular_componentmembrane
B0019001molecular_functionguanyl nucleotide binding
B0019003molecular_functionGDP binding
B0030496cellular_componentmidbody
B0031683molecular_functionG-protein beta/gamma-subunit complex binding
B0031749molecular_functionD2 dopamine receptor binding
B0031821molecular_functionG protein-coupled serotonin receptor binding
B0043434biological_processresponse to peptide hormone
B0043949biological_processregulation of cAMP-mediated signaling
B0046872molecular_functionmetal ion binding
B0051301biological_processcell division
B0060236biological_processregulation of mitotic spindle organization
B0070062cellular_componentextracellular exosome
B0072678biological_processT cell migration
B1904322biological_processcellular response to forskolin
B1904778biological_processpositive regulation of protein localization to cell cortex
C0002232biological_processleukocyte chemotaxis involved in inflammatory response
C0002376biological_processimmune system process
C0002385biological_processmucosal immune response
C0002673biological_processregulation of acute inflammatory response
C0002720biological_processpositive regulation of cytokine production involved in immune response
C0002752biological_processcell surface pattern recognition receptor signaling pathway
C0002879biological_processpositive regulation of acute inflammatory response to non-antigenic stimulus
C0004930molecular_functionG protein-coupled receptor activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006954biological_processinflammatory response
C0007186biological_processG protein-coupled receptor signaling pathway
C0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
C0008289molecular_functionlipid binding
C0016020cellular_componentmembrane
C0019915biological_processlipid storage
C0032024biological_processpositive regulation of insulin secretion
C0032722biological_processpositive regulation of chemokine production
C0032757biological_processpositive regulation of interleukin-8 production
C0042593biological_processglucose homeostasis
C0042995cellular_componentcell projection
C0045444biological_processfat cell differentiation
C0046676biological_processnegative regulation of insulin secretion
C0071398biological_processcellular response to fatty acid
C0090276biological_processregulation of peptide hormone secretion
C1990806biological_processligand-gated ion channel signaling pathway
D0005515molecular_functionprotein binding
D0005834cellular_componentheterotrimeric G-protein complex
D0005886cellular_componentplasma membrane
D0007165biological_processsignal transduction
D0007186biological_processG protein-coupled receptor signaling pathway
D0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
D0016020cellular_componentmembrane
D0031681molecular_functionG-protein beta-subunit binding
D0048144biological_processfibroblast proliferation
D0070062cellular_componentextracellular exosome
D0071380biological_processcellular response to prostaglandin E stimulus
D0071870biological_processcellular response to catecholamine stimulus
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. CSTwLLAGISIERYLgV
ChainResidueDetails
CCYS95-VAL111

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
ALEU68-SER82
AILE155-ILE169
ALEU283-ALA297
AVAL325-GLY339

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
DALA-2
CPRO63-LEU84
CGLN148-LEU173
CSER241-ARG255

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
DCYS64
BTHR181

site_idSWS_FT_FI3
Number of Residues1
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
DCYS64

site_idSWS_FT_FI4
Number of Residues20
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
CALA42-LEU62

site_idSWS_FT_FI5
Number of Residues20
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
CTHR85-ILE105

site_idSWS_FT_FI6
Number of Residues44
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
CGLU106-GLY126
CTHR195-ARG219

site_idSWS_FT_FI7
Number of Residues20
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
CVAL127-VAL147

site_idSWS_FT_FI8
Number of Residues20
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
CASP174-VAL194

site_idSWS_FT_FI9
Number of Residues20
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
CALA220-VAL240

site_idSWS_FT_FI10
Number of Residues20
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
CSER256-SER276

site_idSWS_FT_FI11
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
CASN151
CASN167

222926

PDB entries from 2024-07-24

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