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8IFG

Cryo-EM structure of the Clr6S (Clr6-HDAC) complex from S. pombe

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000785cellular_componentchromatin
A0003714molecular_functiontranscription corepressor activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005730cellular_componentnucleolus
A0006325biological_processchromatin organization
A0006355biological_processregulation of DNA-templated transcription
A0032221cellular_componentRpd3S complex
A0045815biological_processtranscription initiation-coupled chromatin remodeling
A0060090molecular_functionmolecular adaptor activity
A0070822cellular_componentSin3-type complex
B0000510molecular_functionH3-H4 histone complex chaperone activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006325biological_processchromatin organization
B0006338biological_processchromatin remodeling
B0006355biological_processregulation of DNA-templated transcription
B0032221cellular_componentRpd3S complex
B0033698cellular_componentRpd3L complex
B0042393molecular_functionhistone binding
B0045815biological_processtranscription initiation-coupled chromatin remodeling
B0070210cellular_componentRpd3L-Expanded complex
C0000785cellular_componentchromatin
C0004407molecular_functionhistone deacetylase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005730cellular_componentnucleolus
C0005829cellular_componentcytosol
C0006325biological_processchromatin organization
C0010468biological_processregulation of gene expression
C0016787molecular_functionhydrolase activity
C0031078molecular_functionhistone H3K14 deacetylase activity
C0031507biological_processheterochromatin formation
C0032129molecular_functionhistone H3K9 deacetylase activity
C0032221cellular_componentRpd3S complex
C0033558molecular_functionprotein lysine deacetylase activity
C0033698cellular_componentRpd3L complex
C0034739molecular_functionhistone H4K16 deacetylase activity
C0040029biological_processepigenetic regulation of gene expression
C0045815biological_processtranscription initiation-coupled chromatin remodeling
C0070210cellular_componentRpd3L-Expanded complex
C0140937molecular_functionhistone H4K12 deacetylase activity
C0180032molecular_functionhistone H4K5 deacetylase activity
C0180033molecular_functionhistone H4K48 deacetylase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005730cellular_componentnucleolus
D0006281biological_processDNA repair
D0006325biological_processchromatin organization
D0006338biological_processchromatin remodeling
D0006355biological_processregulation of DNA-templated transcription
D0010468biological_processregulation of gene expression
D0032221cellular_componentRpd3S complex
D0035267cellular_componentNuA4 histone acetyltransferase complex
D0045815biological_processtranscription initiation-coupled chromatin remodeling
D0140861biological_processDNA repair-dependent chromatin remodeling
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005730cellular_componentnucleolus
E0006281biological_processDNA repair
E0006325biological_processchromatin organization
E0006338biological_processchromatin remodeling
E0006355biological_processregulation of DNA-templated transcription
E0010468biological_processregulation of gene expression
E0032221cellular_componentRpd3S complex
E0035267cellular_componentNuA4 histone acetyltransferase complex
E0045815biological_processtranscription initiation-coupled chromatin remodeling
E0140861biological_processDNA repair-dependent chromatin remodeling
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005694cellular_componentchromosome
F0005829cellular_componentcytosol
F0006357biological_processregulation of transcription by RNA polymerase II
F0032221cellular_componentRpd3S complex
F0032991cellular_componentprotein-containing complex
F0045815biological_processtranscription initiation-coupled chromatin remodeling
F0046872molecular_functionmetal ion binding
P0005634cellular_componentnucleus
P0005694cellular_componentchromosome
P0006357biological_processregulation of transcription by RNA polymerase II
P0032221cellular_componentRpd3S complex
P0032991cellular_componentprotein-containing complex
P0045815biological_processtranscription initiation-coupled chromatin remodeling
P0046872molecular_functionmetal ion binding
P0060090molecular_functionmolecular adaptor activity
P0072686cellular_componentmitotic spindle
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LATCstDkTIALWDL
ChainResidueDetails
BLEU297-LEU311
BLEU341-LEU355

site_idPS01359
Number of Residues44
DetailsZF_PHD_1 Zinc finger PHD-type signature. CsaChgpgnf.......................................LcCet..Cpns.FHftCidppieeknlpdda...............................WyCneC
ChainResidueDetails
PCYS266-CYS309
FCYS122-CYS165

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues49
DetailsZN_FING: PHD-type 1 => ECO:0000255|PROSITE-ProRule:PRU00146
ChainResidueDetails
PASN263-HIS312
ASER643

site_idSWS_FT_FI2
Number of Residues53
DetailsZN_FING: PHD-type 2 => ECO:0000255|PROSITE-ProRule:PRU00146
ChainResidueDetails
PPRO406-HIS459

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PDB entries from 2024-07-24

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